Skip to Main Content

Author Details

Hans-Ulrich Klein
Columbia University Irving Medical Center
2009
85
35
PMIDPaper TitleJournal TitlePublished Year
38050142ZCCHC17 Modulates Neuronal RNA Splicing and Supports Cognitive Resilience in Alzheimer's Disease.J Neurosci2024
36865313Cell-type-specific regulation of APOE levels in human neurons by the Alzheimer's disease risk gene SORL1.bioRxiv2023
37527018demuxmix: demultiplexing oligonucleotide-barcoded single-cell RNA sequencing data with regression mixture models.Bioinformatics2023
38036535Cell-type-specific Alzheimer's disease polygenic risk scores are associated with distinct disease processes in Alzheimer's disease.Nat Commun2023
35512265Proteome-Wide Discovery of Cortical Proteins That May Provide Motor Resilience to Offset the Negative Effects of Pathologies in Older Adults.J Gerontol A Biol Sci Med Sci2023
36993746ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer's disease.bioRxiv2023
37034737A single-nucleus transcriptome-wide association study implicates novel genes in depression pathogenesis.medRxiv2023
37333223Cell-type-specific Alzheimer's disease polygenic risk scores are associated with distinct disease processes in Alzheimer's disease.medRxiv2023
37131588Genetic insights into the association between inflammatory bowel disease and Alzheimer's disease.medRxiv2023
36747803Multi-region brain transcriptomes uncover two subtypes of aging individuals with differences in Alzheimer risk and the impact of <i>APOEε4</i>.bioRxiv2023
36747615demuxmix: Demultiplexing oligonucleotide-barcoded single-cell RNA sequencing data with regression mixture models.bioRxiv2023
36778249Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts.bioRxiv2023
34482628Epigenomic features related to microglia are associated with attenuated effect of APOE ε4 on Alzheimer's disease risk in humans.Alzheimers Dement2022
35600441Mitochondrial respiratory chain protein co-regulation in the human brain.Heliyon2022
35241503Cortical Proteins and Individual Differences in Cognitive Resilience in Older Adults.Neurology2022
34873813Integration of GWAS and brain transcriptomic analyses in a multiethnic sample of 35,245 older adults identifies DCDC2 gene as predictor of episodic memory maintenance.Alzheimers Dement2022
33446646A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies.Transl Psychiatry2021
34857756Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue.Nat Commun2021
34873174Proximal and distal effects of genetic susceptibility to multiple sclerosis on the T cell epigenome.Nat Commun2021
34742335Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer's disease brain.Mol Neurodegener2021
34153464The association of epigenetic clocks in brain tissue with brain pathologies and common aging phenotypes.Neurobiol Dis2021
34050212Cortical proteins may provide motor resilience in older adults.Sci Rep2021
32255787Bayesian integrative analysis of epigenomic and transcriptomic data identifies Alzheimer's disease candidate genes and networks.PLoS Comput Biol2020
34393677EPIGENOMIC FEATURES RELATED TO MICROGLIA ARE ASSOCIATED WITH ATTENUATED EFFECT OF APOE ε4 ON ALZHEIMER'S DISEASE RISK IN HUMANS.Alzheimers Dement2020
32654306Considerations for integrative multi-omic approaches to explore Alzheimer's disease mechanisms.Brain Pathol2020
32727516BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology.Mol Neurodegener2020
32668255Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.Cell Rep2020
32526197Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology.Neuron2020
30559478Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains.Nat Neurosci2019
29722595How do we measure the epigenome(s)?Mult Scler2018
29802388A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease.Nat Neurosci2018
29874575Tau Activates Transposable Elements in Alzheimer's Disease.Cell Rep2018
30084846A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research.Sci Data2018
27941792Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia.Nat Med2017
28441426Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data.PLoS Med2017
28368004Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer's disease.Nat Commun2017
29379820MS <i>AHI1</i> genetic risk promotes IFNγ<sup>+</sup> CD4<sup>+</sup> T cells.Neurol Neuroimmunol Neuroinflamm2017
28650479AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia.Nat Cell Biol2017
28869584An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome.Nat Neurosci2017
28582573Integrative analysis of multiple genomic variables using a hierarchical Bayesian model.Bioinformatics2017
28761931<i>UNC5C</i> variants are associated with cerebral amyloid angiopathy.Neurol Genet2017
27367165Integrative Analysis of Histone ChIP-seq and RNA-seq Data.Curr Protoc Hum Genet2016
26604133Rheumatoid arthritis-associated RBPJ polymorphism alters memory CD4+ T cells.Hum Mol Genet2016
26515532An evaluation of methods to test predefined genomic regions for differential methylation in bisulfite sequencing data.Brief Bioinform2016
27423266Uncovering the Role of the Methylome in Dementia and Neurodegeneration.Trends Mol Med2016
27573688The epigenome in Alzheimer's disease: current state and approaches for a new path to gene discovery and understanding disease mechanism.Acta Neuropathol2016
25704182Epigenetic dysregulation of KCa 3.1 channels induces poor prognosis in lung cancer.Int J Cancer2015
26643872Genomic landscape of liposarcoma.Oncotarget2015
26179511Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma.Clin Cancer Res2015
25920683Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms.Cancer Cell2015
  • 1 - 50 of 85

Recommended Authors

Li Chen
Indiana University School of Medicine
Career Start Year 2014
Number of shared co-authors 0
Juozas Gordevi??ius
Epigenetic Clock Development Foundation
Career Start Year 2012
Number of shared co-authors 0
Nyasha Chambwe
Institute of Molecular Medicine, Feinstein Institutes for Medical Research
Career Start Year 2010
Number of shared co-authors 1
Brandy Klotzle
Departments of Bioinformatics and Clinical Genomics, Illumina Inc.
Career Start Year 2009
Number of shared co-authors 2
Kathleen M Fisch
Center for Computational Biology and Bioinformatics, University of California
Career Start Year 2009
Number of shared co-authors 2
Eunjee Lee
Chungnam National University
Career Start Year 2007
Number of shared co-authors 10
Nongluk Plongthongkum
King Mongkut's University of Technology Thonburi
Career Start Year 2007
Number of shared co-authors 1
Gabriel E Hoffman
Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai
Career Start Year 2006
Number of shared co-authors 17
Yassen Assenov
German Cancer Research Center (DKFZ)
Career Start Year 2006
Number of shared co-authors 0
Altuna Akalin
Berlin Institute for Medical Systems Biology
Career Start Year 2006
Number of shared co-authors 2
Christoph Bock
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Career Start Year 2005
Number of shared co-authors 8
Andrew E Teschendorff
UCL Cancer Institute, University College London
Career Start Year 2005
Number of shared co-authors 3
Kun Zhang
China Pharmaceutical University
Career Start Year 2005
Number of shared co-authors 1
Beth Wilmot
Knight Cancer Institute, Oregon Health & Science University
Career Start Year 2004
Number of shared co-authors 9
Lily Wang
College of Science, The Australian National University
Career Start Year 2004
Number of shared co-authors 0
David W Craig
University of Southern California
Career Start Year 2004
Number of shared co-authors 6
Kasper D Hansen
Johns Hopkins University School of Medicine
Career Start Year 2004
Number of shared co-authors 0
Zhaohui S Qin
Emory University
Career Start Year 2002
Number of shared co-authors 2
Mikhail G Dozmorov
Virginia Commonwealth University
Career Start Year 2001
Number of shared co-authors 1
Rafael A Irizarry
Dana-Farber Cancer Institute
Career Start Year 2001
Number of shared co-authors 3
Peter J Park
Harvard Medical School
Career Start Year 2001
Number of shared co-authors 5
Shawn Levy
HudsonAlpha Institute for Biotechnology
Career Start Year 1999
Number of shared co-authors 4
Steve Horvath
David Geffen School of Medicine, University of California los angeles
Career Start Year 1998
Number of shared co-authors 11
Martin Hirst
University of British Columbia
Career Start Year 1998
Number of shared co-authors 4
Mark D Robinson
University of Zurich
Career Start Year 1997
Number of shared co-authors 0
Shannon K McWeeney
Oregon Health & Science University, University of California Berkeley
Career Start Year 1997
Number of shared co-authors 10
Wolfgang Huber
Technische Universitat Munchen
Career Start Year 1995
Number of shared co-authors 2
Wim Van Criekinge
Ghent University
Career Start Year 1995
Number of shared co-authors 0
Jean-Pierre A Kocher
Mayo Clinic
Career Start Year 1991
Number of shared co-authors 1
Holger Heyn
Barcelona Institute of Science and Technology, Spain Universitat Pompeu Fabra
Career Start Year 1988
Number of shared co-authors 2

Collaborators

Philip L De Jager
Columbia University Medical Center
Co-authored papers 38
David A Bennett
Rush University Medical Center
Co-authored papers 33
Torsten Haferlach
Taussig Cancer Institute, Cleveland Clinic
Co-authored papers 16
Alexander Kohlmann
Oncology R&D
Co-authored papers 15
Lei Yu
Rush University Medical Center
Co-authored papers 14
Charles C White
University of Tennessee College of Medicine Chattanooga
Co-authored papers 13
Wolfgang E Berdel
University Hospital Munster
Co-authored papers 10
Chris Gaiteri
SUNY Upstate Medical University
Co-authored papers 7
Sara Mostafavi
University of British Columbia and BC Children's Hospital
Co-authored papers 6
Lori B Chibnik
Co-authored papers 6
Hyun-Sik Yang
Massachusetts General Hospital, the Gordon Center for Medical Imaging
Co-authored papers 6
Vladislav A Petyuk
Pacific Northwest National Laboratory
Co-authored papers 5
Seishi Ogawa
Kyoto University
Co-authored papers 5
Nil??fer Ertekin-Taner
Mayo Clinic
Co-authored papers 5
Bin Zhang
Graduate School of Medicine, The University of Tokyo
Co-authored papers 4
Reisa A Sperling
Brigham and Women's Hospital, Massachusetts General Hospital
Co-authored papers 4
Hiroko Tanaka
Tokyo Medical and Dental University
Co-authored papers 4
Satoru Miyano
Tokyo Medical and Dental University
Co-authored papers 4
Mariet Allen
Mayo Clinic
Co-authored papers 4
Allan I Levey
Emory University School of Medicine
Co-authored papers 3
Badri N Vardarajan
Columbia University Irving Medical Center, New York Presbyterian Hospital
Co-authored papers 3
Monika Stoll
Co-authored papers 3
Bartlomiej Przychodzen
Vanda Pharmaceuticals Inc.
Co-authored papers 3
Eric B Dammer
Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine
Co-authored papers 2
Joshua M Shulman
Baylor College of Medicine
Co-authored papers 2
Logan Dumitrescu
Vanderbilt University Medical Center
Co-authored papers 2
Benjamin A Logsdon
Fred Hutchinson Cancer Research Center
Co-authored papers 2
Li-Huei Tsai
The Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Co-authored papers 2
Lara M Mangravite
Children's Hospital Oakland Research Institute
Co-authored papers 2
Keith A Johnson
Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School
Co-authored papers 2
Release 1.2