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Author Details

Christian M Metallo
Massachusetts Institute of Technology
2002
122
52
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36931394Glycocalyx engineering with heparan sulfate mimetics attenuates Wnt activity during adipogenesis to promote glucose uptake and metabolism.J Biol Chem2023
37893215Stable Isotope-Assisted Untargeted Metabolomics Identifies ALDH1A1-Driven Erythronate Accumulation in Lung Cancer Cells.Biomedicines2023
37537368Methionine and H<sub>2</sub>S alter cancer-immune dialogue.Nat Metab2023
38092754Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis.Nat Commun2023
37115691iPSC-derived retinal pigmented epithelial cells from patients with macular telangiectasia show decreased mitochondrial function.J Clin Invest2023
37077889Reduced methionine synthase expression results in uracil accumulation in mitochondrial DNA and impaired oxidative capacity.PNAS Nexus2023
37307855Sources and Sinks of Serine in Nutrition, Health, and Disease.Annu Rev Nutr2023
37134162Inter-organelle cross-talk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress.Sci Adv2023
37131637EGFR [+] lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth.bioRxiv2023
36997154Divergent amino acid and sphingolipid metabolism in patients with inherited neuro-retinal disease.Mol Metab2023
36697822Insulin-regulated serine and lipid metabolism drive peripheral neuropathy.Nature2023
36882540Publisher Correction: Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome.Nature2023
34426440Establishment of Patient-Derived Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumor Models for Predicting Therapeutic Response.Clin Cancer Res2022
35545049The lactate-NAD<sup>+</sup> axis activates cancer-associated fibroblasts by downregulating p62.Cell Rep2022
35470095Daily running enhances molecular and physiological circadian rhythms in skeletal muscle.Mol Metab2022
35728000Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy.Eur Heart J2022
35655024Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages.Nat Metab2022
37118545Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia.Nat Aging2022
35941112Acetate reprograms gut microbiota during alcohol consumption.Nat Commun2022
36198801Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome.Nature2022
361155941-Deoxysphingolipid synthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells.J Lipid Res2022
33122122Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function.Mol Metab2021
33740421Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis.Cancer Cell2021
33514556Microbiota control of maternal behavior regulates early postnatal growth of offspring.Sci Adv2021
33758422Serine biosynthesis defect due to haploinsufficiency of PHGDH causes retinal disease.Nat Metab2021
33670656Itaconate Alters Succinate and Coenzyme A Metabolism via Inhibition of Mitochondrial Complex II and Methylmalonyl-CoA Mutase.Metabolites2021
34646987Charting oncogenicity of genes and variants across lineages via multiplexed screens in teratomas.iScience2021
34525352NaCT/SLC13A5 facilitates citrate import and metabolism under nutrient-limited conditions.Cell Rep2021
34652935Progressive alterations in amino acid and lipid metabolism correlate with peripheral neuropathy in <i>Polg</i><sup>D257A</sup> mice.Sci Adv2021
33984270PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay.Dev Cell2021
33399331Dairy Fat Intake, Plasma Pentadecanoic Acid, and Plasma Iso-heptadecanoic Acid Are Inversely Associated With Liver Fat in Children.J Pediatr Gastroenterol Nutr2021
33296743Exploring the evolutionary roots and physiological function of itaconate.Curr Opin Biotechnol2021
32532969Sub-nanowatt microfluidic single-cell calorimetry.Nat Commun2020
32029222Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury.Mol Metab2020
31893370Deuterium Tracing to Interrogate Compartment-Specific NAD(P)H Metabolism in Cultured Mammalian Cells.Methods Mol Biol2020
31941676Statins Limit Coenzyme Q Synthesis and Metabolically Synergize with MEK Inhibition in Pancreatic Tumors.Cancer Res2020
33044062A Small Molecule Fluorogenic Probe for the Detection of Sphingosine in Living Cells.J Am Chem Soc2020
33152322TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation.Cell Metab2020
33005401Disruption of redox homeostasis for combinatorial drug efficacy in <i>K-Ras</i> tumors as revealed by metabolic connectivity profiling.Cancer Metab2020
32683313Cryptochromes Suppress HIF1α in Muscles.iScience2020
32682952Disruption of the sodium-dependent citrate transporter SLC13A5 in mice causes alterations in brain citrate levels and neuronal network excitability in the hippocampus.Neurobiol Dis2020
32766885Tolerance to graded dosages of histidine supplementation in healthy human adults.Am J Clin Nutr2020
32650717Escher-Trace: a web application for pathway-based visualization of stable isotope tracing data.BMC Bioinformatics2020
32589943PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression.Cancer Cell2020
32788725Serine restriction alters sphingolipid diversity to constrain tumour growth.Nature2020
32697997Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes.Cell Rep2020
32839596Fructose stimulated de novo lipogenesis is promoted by inflammation.Nat Metab2020
32201132Tracing insights into de novo lipogenesis in liver and adipose tissues.Semin Cell Dev Biol2020
32231310Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer.Nat Cell Biol2020
30605676Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD.Cell Rep2019
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Collaborators

Thekla Cordes
Technische Universitat Braunschweig, Helmholtz Centre for Infection Research
Co-authored papers 27
Martina Wallace
University College Dublin
Co-authored papers 24
Gregory Stephanopoulos
Massachusetts Institute of Technology
Co-authored papers 13
Courtney R Green
The Salk Institute for Biological Studies
Co-authored papers 13
Michal K Handzlik
The Salk Institute for Biological Studies
Co-authored papers 12
Mehmet G Badur
University of California San Diego
Co-authored papers 10
Jivani M Gengatharan
The Salk Institute for Biological Studies
Co-authored papers 10
Maria T Diaz-Meco
Co-authored papers 8
Jorge Moscat
Co-authored papers 8
Juan J de Pablo
University of Chicago
Co-authored papers 6
Angeles Duran
Co-authored papers 6
Juan F Linares
Co-authored papers 5
Michael Karin
Co-authored papers 5
Marin L Gantner
Lowy Medical Research Institute
Co-authored papers 5
Miguel Reina-Campos
Co-authored papers 5
Christopher S Ahn
University of California
Co-authored papers 4
Regis Fallon
Lowy Medical Research Institute
Co-authored papers 4
Pedro Cabrales
University of California
Co-authored papers 3
Andrew M Lowy
University of California San Diego
Co-authored papers 3
Melanie Bahlo
Co-authored papers 3
Jose H Magana
University of California
Co-authored papers 3
Rando Allikmets
Columbia University Medical Center
Co-authored papers 3
Jason W Locasale
Duke University
Co-authored papers 3
Alan Saghatelian
Salk Institute for Biological Studies
Co-authored papers 3
Rob Knight
University of California
Co-authored papers 3
Paul S Bernstein
University of Utah
Co-authored papers 3
Lewis C Cantley
Co-authored papers 3
Prashant Mali (CM4AI)
University of California San Diego
Co-authored papers 3
Joan S Brugge
Co-authored papers 2
Lea Scheppke
Lowy Medical Research Institute, California The Scripps Research Institute
Co-authored papers 2
Release 1.2