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Author Details

Walid A Houry
University of Toronto
1994
118
44
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37931588Broad spectrum post-entry inhibitors of coronavirus replication: Cardiotonic steroids and monensin.Virology2024
36602710Second Virtual International Symposium on Cellular and Organismal Stress Responses, September 8-9, 2022.Cell Stress Chaperones2023
37631136Unveiling the Role of Sorghum RPAP3 in the Function of R2TP Complex: Insights into Protein Assembly in Plants.Plants (Basel)2023
37706687On a path toward a broad-spectrum anti-viral: inhibition of HIV-1 and coronavirus replication by SR kinase inhibitor harmine.J Virol2023
37660904The RavA-ViaA chaperone complex modulates bacterial persistence through its association with the fumarate reductase enzyme.J Biol Chem2023
36586405Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.Structure2023
34446368Substrates and interactors of the ClpP protease in the mitochondria.Curr Opin Chem Biol2022
35852937Analysis of the Evolution of the MoxR ATPases.J Phys Chem A2022
36533084Cellular functions of the ClpP protease impacting bacterial virulence.Front Mol Biosci2022
35929764Characterization of TR-107, a novel chemical activator of the human mitochondrial protease ClpP.Pharmacol Res Perspect2022
36008939The Role of Hsp90-R2TP in Macromolecular Complex Assembly and Stabilization.Biomolecules2022
35245501Recent structural insights into the mechanism of ClpP protease regulation by AAA+ chaperones and small molecules.J Biol Chem2022
34492227Assembly principles of the human R2TP chaperone complex reveal the presence of R2T and R2P complexes.Structure2022
33421500Purification and characterization of a novel and conserved TPR-domain protein that binds both Hsp90 and Hsp70 and is expressed in all developmental stages of Leishmania major.Biochimie2021
33775623Leishmania major RUVBL1 has a hexameric conformation in solution and, in the presence of RUVBL2, forms a heterodimer with ATPase activity.Arch Biochem Biophys2021
35062264The Thiazole-5-Carboxamide GPS491 Inhibits HIV-1, Adenovirus, and Coronavirus Replication by Altering RNA Processing/Accumulation.Viruses2021
33958595Author Correction: Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex.Nat Commun2021
33436616Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex.Nat Commun2021
32295120Sorafenib as an Inhibitor of RUVBL2.Biomolecules2020
31916936A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery.Elife2020
33237740Development of Antibiotics That Dysregulate the <i>Neisserial</i> ClpP Protease.ACS Infect Dis2020
32302629Heat shock protein 90 kDa (Hsp90) from Aedes aegypti has an open conformation and is expressed under heat stress.Int J Biol Macromol2020
32208144AAA+ proteins.Curr Biol2020
30954531Strategies for purification of the bacteriophage HK97 small and large terminase subunits that yield pure and homogeneous samples that are functional.Protein Expr Purif2019
31754640ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores.Commun Biol2019
31734827Plasmodium falciparum R2TP complex: driver of parasite Hsp90 function.Biophys Rev2019
30194284Multiple functionalities of molecular chaperones revealed through systematic mapping of their interaction networks.J Biol Chem2019
31241890Chemical Modulation of Human Mitochondrial ClpP: Potential Application in Cancer Therapeutics.ACS Chem Biol2019
31452139Recent Advances in Targeting Human Mitochondrial AAA+ Proteases to Develop Novel Cancer Therapeutics.Adv Exp Med Biol2019
29177666Computational Analysis of the Chaperone Interaction Networks.Methods Mol Biol2018
29941580Reversible inhibition of the ClpP protease via an N-terminal conformational switch.Proc Natl Acad Sci U S A2018
30126533Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death.Cell Chem Biol2018
30484152The Multiple Functions of the PAQosome: An R2TP- and URI1 Prefoldin-Based Chaperone Complex.Adv Exp Med Biol2018
30333982Editorial: The Role of AAA+ Proteins in Protein Repair and Degradation.Front Mol Biosci2018
29775273The Role of ClpP Protease in Bacterial Pathogenesis and Human Diseases.ACS Chem Biol2018
29659649Systems analysis of the genetic interaction network of yeast molecular chaperones.Mol Omics2018
29203338The PAQosome, an R2TP-Based Chaperone for Quaternary Structure Formation.Trends Biochem Sci2018
27979649The RavA-ViaA Chaperone-Like System Interacts with and Modulates the Activity of the Fumarate Reductase Respiratory Complex.J Mol Biol2017
28884116The Role of Pontin and Reptin in Cellular Physiology and Cancer Etiology.Front Mol Biosci2017
28903051Features of the Chaperone Cellular Network Revealed through Systematic Interaction Mapping.Cell Rep2017
27112599Architecture and Nucleotide-Dependent Conformational Changes of the Rvb1-Rvb2 AAA+ Complex Revealed by Cryoelectron Microscopy.Structure2016
27265850Mechanism of Amyloidogenesis of a Bacterial AAA+ Chaperone.Structure2016
27080013Structural insights into the Escherichia coli lysine decarboxylases and molecular determinants of interaction with the AAA+ ATPase RavA.Sci Rep2016
26818454Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity.J Med Chem2016
25316676Novel function discovery with GeneMANIA: a new integrated resource for gene function prediction in Escherichia coli.Bioinformatics2015
26621473Substrate Interaction Networks of the Escherichia coli Chaperones: Trigger Factor, DnaK and GroEL.Adv Exp Med Biol2015
26058080Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.Cancer Cell2015
25988184The AAA+ proteins Pontin and Reptin enter adult age: from understanding their basic biology to the identification of selective inhibitors.Front Mol Biosci2015
25636407Yeast rvb1 and rvb2 proteins oligomerize as a conformationally variable dodecamer with low frequency.J Mol Biol2015
24454883The MoxR ATPase RavA and its cofactor ViaA interact with the NADH:ubiquinone oxidoreductase I in Escherichia coli.PLoS One2014
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Collaborators

Yoshito Kakihara
Niigata University
Co-authored papers 10
Mohan Babu
University of Regina
Co-authored papers 10
Sadhna Phanse
University of Regina
Co-authored papers 9
Rongmin Zhao
University of Toronto
Co-authored papers 8
Andrew Emili
Boston University School of Medicine, Boston University
Co-authored papers 7
Harold A Scheraga
Co-authored papers 7
Jack F Greenblatt
College Street, University of Toronto
Co-authored papers 7
Majida El Bakkouri
Human Health Therapeutics Research Centre, National Research Council Canada
Co-authored papers 6
Lewis E Kay
University of Toronto
Co-authored papers 5
Ashwani Kumar
Bhabha Atomic Research Centre
Co-authored papers 5
Zoran Minic
University of Ottawa
Co-authored papers 4
Charles Boone
University of Toronto
Co-authored papers 4
Ramy H Malty
University of Toronto, University of Regina
Co-authored papers 3
Gary D Bader
University of Toronto
Co-authored papers 3
Michael Costanzo
Co-authored papers 3
James Vlasblom
University of Regina
Co-authored papers 3
Yunchen Gong
University of Toronto
Co-authored papers 2
Daniel R Southworth
The Institute for Neurodegenerative Diseases, University of California San Francisco
Co-authored papers 2
Quaid Morris
Sloan Kettering Institute
Co-authored papers 2
Chad L Myers
University of Minnesota - Twin Cities
Co-authored papers 2
Franco J Vizeacoumar
College of Medicine, University of Saskatchewan
Co-authored papers 2
Bahram Samanfar
Agriculture and Agri-Food Canada
Co-authored papers 2
Benoit Chabot
Agriculture and Agri-Food Canada
Co-authored papers 2
Anne-Claude Gingras
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 2
Igor Stagljar
University of Toronto, Canada Mediterranean Institute for Life Sciences
Co-authored papers 2
Alla Gagarinova
University of Regina
Co-authored papers 2
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 2
Zhaolei Zhang
University of Toronto
Co-authored papers 2
Ashkan Golshani
Ottawa Institute of Systems Biology, Carleton University
Co-authored papers 2
Renee L Brost
Cubist Pharmaceuticals, Inc.
Co-authored papers 2
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