Author details

Full Name

John G Luz

Affiliation

Beth Israel Deaconess Medical Center and Harvard Medical School

ORCID

Career Start Year

1994

Papers

H Index

Expertise

CM4AI Collaborator

Andrej Sali (CM4AI)

PMID	Paper Title	Journal Title	Published Year
33246032	Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP).	Biochim Biophys Acta Gen Subj	2021
33724805	Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen.	Biochemistry	2021
32690595	The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase.	J Lipid Res	2020
28190634	Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.	Bioorg Med Chem Lett	2017
26882000	Correction to The 2.5 Ã¿ Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD(+)) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition.	J Med Chem	2016
26653180	Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors.	J Med Chem	2016
27554445	Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors.	Bioorg Med Chem Lett	2016
26683992	2-Chloro-4-[[(1R,2R)-2-hydroxy-2-methyl-cyclopentyl]amino]-3-methyl-benzonitrile: A Transdermal Selective Androgen Receptor Modulator (SARM) for Muscle Atrophy.	J Med Chem	2016
25961169	Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.	J Med Chem	2015
26218343	Indole Glucocorticoid Receptor Antagonists Active in a Model of Dyslipidemia Act via a Unique Association with an Agonist Binding Site.	J Med Chem	2015
24446728	Glucocorticoid receptor modulators informed by crystallography lead to a new rationale for receptor selectivity, function, and implications for structure-based design.	J Med Chem	2014
23311358	The 2.5 Ã¿ crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition.	J Med Chem	2013
24367637	Structural context of disease-associated mutations and putative mechanism of autoinhibition revealed by X-ray crystallographic analysis of the EZH2-SET domain.	PLoS One	2013
20156452	Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1.	J Mol Biol	2010
18235434	Protein production and purification.	Nat Methods	2008
16140327	Crystal structure of viral macrophage inflammatory protein I encoded by Kaposi's sarcoma-associated herpesvirus at 1.7A.	J Mol Biol	2005
15084288	Supine orientation of a murine MHC class I molecule on the membrane bilayer.	Curr Biol	2004
15476818	Analysis of the class I aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99A resolution.	J Mol Biol	2004
14978103	A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: functional and structural aspects.	J Immunol	2004
12672694	XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators.	Genes Dev	2003
11988465	Structural and thermodynamic correlates of T cell signaling.	Annu Rev Biophys Biomol Struct	2002
11994422	Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions.	J Exp Med	2002
11598300	Observation of covalent intermediates in an enzyme mechanism at atomic resolution.	Science	2001
11092933	Crystallization of retinol dehydratase from Spodoptera frugiperda: improvement of crystal quality by modification by ethylmercurythiosalicylate.	Acta Crystallogr D Biol Crystallogr	2000
9857081	Substrate specificity and kinetic mechanism of the insect sulfotransferase, retinol dehydratase.	J Biol Chem	1998
7916210	Novel Cl(-)-dependent intracellular pH regulation in murine MDR 1 transfectants and potential implications.	Biochemistry	1994
7911682	Transfection of mu MDR 1 inhibits Na(+)-independent Cl-/-HCO3 exchange in Chinese hamster ovary cells.	Biochemistry	1994

1 - 27 of 27

Timothy S Strutzenberg

Salk Institute for Biological Studies

Career Start Year 2014

Number of shared co-authors 4

Andrew C Kruse

Blavatnik Institute, Harvard Medical School

Career Start Year 2008

Number of shared co-authors 2

Suwen Zhao

ShanghaiTech University, China iHuman Institute

Career Start Year 2006

Number of shared co-authors 4

Lisa M Miller Jenkins

National Cancer Institute, National Institutes of Health

Career Start Year 2005

Number of shared co-authors 0

David Marciano

Stanford Cardiovascular Institute (L.W., Stanford University School of Medicine

Career Start Year 2003

Number of shared co-authors 3

Gerald H Lushington

Inc. 16 Dekalb Pike

Career Start Year 2002

Number of shared co-authors 0

Marc C Deller

Incyte Corporation

Career Start Year 2000

Number of shared co-authors 3

Udupi A Ramagopal

Poornaprajna Institute of Scientific Research (PPISR)

Career Start Year 1998

Number of shared co-authors 10

Yury Patskovsky

New York University Grossman School of Medicine

Career Start Year 1998

Number of shared co-authors 12

Rodrigo J Carbajo

Oncology R&D

Career Start Year 1997

Number of shared co-authors 1

Aw Edith Chan

The Walter and Eliza Hall Institute of Medical Research

Career Start Year 1993

Number of shared co-authors 1

Diana R Tomchick

University of Texas Southwestern Medical Center

Career Start Year 1993

Number of shared co-authors 1

Matthew R Redinbo

University of North Carolina at Chapel Hill

Career Start Year 1993

Number of shared co-authors 0

Michael J Romanowski

Sunesis Pharmaceuticals, Inc. 395 Oyster Point Boulevard

Career Start Year 1993

Number of shared co-authors 4

Gye Won Han

Bridge Institute, University of Southern California

Career Start Year 1991

Number of shared co-authors 5

Andreas Hofmann

Heidelberg University

Career Start Year 1989

Number of shared co-authors 0

David E Timm

Lilly Research Laboratories

Career Start Year 1988

Number of shared co-authors 1

Miriam Eisenstein

Weizmann Institute of Science

Career Start Year 1988

Number of shared co-authors 6

Patrick R Griffin

The Scripps Research Institute

Career Start Year 1987

Number of shared co-authors 7

Paul C Driscoll

The Francis Crick Institute

Career Start Year 1987

Number of shared co-authors 3

Diane Joseph-McCarthy

Boston University

Career Start Year 1987

Number of shared co-authors 1

Rob Hooft van Huijsduijnen

Vrije Universiteit Amsterdam (VU)

Career Start Year 1987

Number of shared co-authors 0

Antonio Macchiarulo

Department of Pharmaceutical Sciences, University of Perugia

Career Start Year 1986

Number of shared co-authors 1

Stuart L Schreiber

Broad Institute

Career Start Year 1985

Number of shared co-authors 7

Lu-Yun Lian

Institute of Systems, The University of Liverpool

Career Start Year 1984

Number of shared co-authors 3

Ruben Abagyan

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California

Career Start Year 1981

Number of shared co-authors 4

James A Wells

Department of Pharmaceutical Chemistry, University of California San Francisco

Career Start Year 1974

Number of shared co-authors 6

Tom L Blundell

Heartand Lung Research Institute, University of Cambridge

Career Start Year 1971

Number of shared co-authors 3

Robert M Stroud

University of California San Francisco

Career Start Year 1965

Number of shared co-authors 3

Jens Meiler

Vanderbilt University

Career Start Year 1954

Number of shared co-authors 6

row(s) 1 - 30 of 30

Ian A Wilson

The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology

Co-authored papers 9

Tarun Gheyi

New York SGX Research Center for Structural Genomics

Co-authored papers 5

Stephen K Burley

The State University of New Jersey

Co-authored papers 2

Kevin T Bain

NYU Langone Hospital - Brooklyn Brooklyn

Co-authored papers 2

Xun Zhao

Co-authored papers 2

Shane Atwell

Lilly Research Laboratories

Co-authored papers 2

Devon A Thompson

Stanford University

Co-authored papers 2

J Michael Sauder

Eli Lilly and Co.

Co-authored papers 2

Jeffrey B Bonanno

Albert Einstein College of Medicine

Co-authored papers 2

J S Emtage

Co-authored papers 2

Rong Xiao

School of Public Health, Capital Medical University

Co-authored papers 1

Sirano Dhe-Paganon

Dana-Farber Cancer Institute

Co-authored papers 1

Mei Jiang

The University of Texas MD Anderson Cancer Center

Co-authored papers 1

Kristin C Gunsalus

Center for Genomics and Systems Biology, New York University Abu Dhabi (NYUAD)

Co-authored papers 1

Masayori Inouye

Robert Wood Johnson Medical School, Rutgers University

Co-authored papers 1

Gaetano T Montelione

Rensselaer Polytechnic Institute

Co-authored papers 1

Ritu Shastry

Co-authored papers 1

Yingchun Wang

Co-authored papers 1

Deborah Palliser

Albert Einstein College of Medicine

Co-authored papers 1

Sinem A Ozyurt

University of Central Florida

Co-authored papers 1

Opher Gileadi

Structural Genomics Consortium Karolinska Institute Stockholm Sweden.

Co-authored papers 1

Zihe Rao

Nankai University

Co-authored papers 1

Kellie Cunningham

Co-authored papers 1

Joseph D Ho

University of California san francisco

Co-authored papers 1

F W Studier

Brookhaven National Laboratory

Co-authored papers 1

P??r Nordlund

Karolinska Institutet, BioClinicum J6

Co-authored papers 1

Geoffrey S Waldo

Los Alamos National Laboratory

Co-authored papers 1

Yunyu Shi

University of Science & Technology of China

Co-authored papers 1

Dongyan Wang

Guizhou Medical University

Co-authored papers 1

Chang-Yub Kim

Los Alamos National Laboratory

Co-authored papers 1

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