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Author Details

Steven M Hersch
Inc. University Avenue
1980
148
67
Timothy Clark (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36842293Application of an electro elution system for direct purification of linear covalently closed DNA fragments.J Chromatogr B Analyt Technol Biomed Life Sci2023
35170086Utility of the Huntington's Disease Prognostic Index Score for a Perimanifest Clinical Trial.Mov Disord2022
35747889Suicidality Risk Factors Across the CARE-HD, 2CARE, and CREST-E Clinical Trials in Huntington Disease.Neurol Clin Pract2022
36410013A natural history study to track brain and spinal cord changes in individuals with Friedreich's ataxia: TRACK-FA study protocol.PLoS One2022
36294700The Vasopressin 1a Receptor Antagonist SRX246 Reduces Aggressive Behavior in Huntington's Disease.J Pers Med2022
33106388Association of Dilated Perivascular Spaces and Disease Severity in Patients With Huntington Disease.Neurology2021
33593945A stress-induced block in dicarboxylate uptake and utilization in <i>Salmonella</i>.J Bacteriol2021
34161288Sensing of intracellular Hcp levels controls T6SS expression in <i>Vibrio cholerae</i>.Proc Natl Acad Sci U S A2021
34366879Impaired Cerebrovascular Reactivity in Huntington's Disease.Front Physiol2021
34281388Engineered Type Six Secretion Systems Deliver Active Exogenous Effectors and Cre Recombinase.mBio2021
32553162Differential Cellular Response to Translocated Toxic Effectors and Physical Penetration by the Type VI Secretion System.Cell Rep2020
32094588Envelope stress responses defend against type six secretion system attacks independently of immunity proteins.Nat Microbiol2020
33053336Defending against the Type Six Secretion System: beyond Immunity Genes.Cell Rep2020
33207828Safety and Tolerability of SRX246, a Vasopressin 1a Antagonist, in Irritable Huntington's Disease Patients-A Randomized Phase 2 Clinical Trial.J Clin Med2020
32719152The <i>Salmonella</i> LysR Family Regulator RipR Activates the SPI-13-Encoded Itaconate Degradation Cluster.Infect Immun2020
32686867Clinical Outcomes and Selection Criteria for Prodromal Huntington's Disease Trials.Mov Disord2020
31381523The Prospective Huntington At-Risk Observational Study (PHAROS): The Emotional Well-Being, Safety and Feasibility of Long-Term Research Participation.J Huntingtons Dis2019
31636107Double Tubular Contractile Structure of the Type VI Secretion System Displays Striking Flexibility and Elasticity.J Bacteriol2019
30363459Electrocardiogram Abnormalities Suggest Aberrant Cardiac Conduction in Huntington's Disease.Mov Disord Clin Pract2018
30090698Complex spatial and temporally defined myelin and axonal degeneration in Huntington disease.Neuroimage Clin2018
28533375KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.Proc Natl Acad Sci U S A2017
29142089Motor, cognitive, and functional declines contribute to a single progressive factor in early HD.Neurology2017
28701493The CREST-E study of creatine for Huntington disease: A randomized controlled trial.Neurology2017
25941073Rho Kinase Pathway Alterations in the Brain and Leukocytes in Huntington's Disease.Mol Neurobiol2016
26569098Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials.JAMA Neurol2016
27983565LBH589, A Hydroxamic Acid-Derived HDAC Inhibitor, is Neuroprotective in Mouse Models of Huntington's Disease.J Huntingtons Dis2016
26273688A systems-level "misunderstanding": the plasma metabolome in Huntington's disease.Ann Clin Transl Neurol2015
24510496PRECREST: a phase II prevention and biomarker trial of creatine in at-risk Huntington disease.Neurology2014
25014023Altered selenium status in Huntington's disease: neuroprotection by selenite in the N171-82Q mouse model.Neurobiol Dis2014
25148683Translation initiation rate determines the impact of ribosome stalling on bacterial protein synthesis.J Biol Chem2014
25144653EF-P dependent pauses integrate proximal and distal signals during translation.PLoS Genet2014
23277358(R)-β-lysine-modified elongation factor P functions in translation elongation.J Biol Chem2013
24146952Iron accumulates in Huntington's disease neurons: protection by deferoxamine.PLoS One2013
23966247HTRF analysis of soluble huntingtin in PHAROS PBMCs.Neurology2013
23611909Divergent protein motifs direct elongation factor P-mediated translational regulation in Salmonella enterica and Escherichia coli.mBio2013
23644918Candidate glutamatergic and dopaminergic pathway gene variants do not influence Huntington's disease motor onset.Neurogenetics2013
23416183A novel method for detecting 7-methyl guanine reveals aberrant methylation levels in Huntington disease.Anal Biochem2013
22081389Loss of elongation factor P disrupts bacterial outer membrane integrity.J Bacteriol2012
25063191Plasma 8-hydroxy-2'-deoxyguanosine Levels in Huntington Disease and Healthy Controls Treated with Coenzyme Q10.J Huntingtons Dis2012
23200855The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models.Cell Rep2012
22771793TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease.Biochem Biophys Res Commun2012
22825315Population stratification may bias analysis of PGC-1α as a modifier of age at Huntington disease motor onset.Hum Genet2012
22393169Alterations in brain transition metals in Huntington disease: an evolving and intricate story.Arch Neurol2012
22387017Common SNP-based haplotype analysis of the 4p16.3 Huntington disease gene region.Am J Hum Genet2012
22323755CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion.Neurology2012
21134349Microtiter plate quantification of mutant and wild-type huntingtin normalized to cell count.Anal Biochem2011
21791548The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS.Hum Mol Genet2011
21969577Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse.Proc Natl Acad Sci U S A2011
21611979A tale of two factors: what determines the rate of progression in Huntington's disease? A longitudinal MRI study.Mov Disord2011
20074541Identification of phenylbutyrate-generated metabolites in Huntington disease patients using parallel liquid chromatography/electrochemical array/mass spectrometry and off-line tandem mass spectrometry.Anal Biochem2010
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Collaborators

Emory University School of Medicine
Co-authored papers 13
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Novartis Institutes for Biomedical Research
Co-authored papers 8
Belfast City Hospital
Co-authored papers 7
Co-authored papers 7
Houston Methodist Research Institute
Co-authored papers 6
Co-authored papers 5
Boston University Chobanian & Avedisian School of Medicine
Co-authored papers 5
Co-authored papers 4
Massachusetts Institute of Technology
Co-authored papers 4
Co-authored papers 4
Co-authored papers 4
Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Co-authored papers 3
Harvard Medical School
Co-authored papers 3
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital
Co-authored papers 3
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Co-authored papers 2
Center for Neuro-Infections, Ageo Central General Hospital
Co-authored papers 2
Co-authored papers 2
BioMarin Pharmaceutical Inc.
Co-authored papers 2
Sorbonne University, Paris Brain Institute - ICM, Inserm, CNRS
Co-authored papers 2
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Co-authored papers 2
Pfizer Neuroscience and Pain Research Unit, Pfizer Ltd.
Co-authored papers 2
University of Leicester
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Buck Institute for Research on Aging
Co-authored papers 2
National Institute of Neurological Disorders and Stroke
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