Skip to Main Content

Author Details

Deborah H Spector
1971
131
52
PMIDPaper TitleJournal TitlePublished Year
36097162SREBP2-dependent lipid gene transcription enhances the infection of human dendritic cells by Zika virus.Nat Commun2022
33328307Zika virus is transmitted in neural progenitor cells via cell-to-cell spread and infection is inhibited by the autophagy inducer trehalose.J Virol2021
31611098A vaccine containing highly purified virus particles in adjuvant provides high level protection against genital infection and disease in guinea pigs challenged intravaginally with homologous and heterologous strains of herpes simplex virus type 2.Vaccine2020
29237845Human Cytomegalovirus Replication Is Inhibited by the Autophagy-Inducing Compounds Trehalose and SMER28 through Distinctively Different Mechanisms.Journal of Virology2018
27775709RNA-binding protein CPEB1 remodels host and viral RNA landscapes.Nat Struct Mol Biol2016
26559848Trehalose, an mTOR-Independent Inducer of Autophagy, Inhibits Human Cytomegalovirus Infection in Multiple Cell Types.Journal of Virology2016
25776080Human cytomegalovirus riding the cell cycle.Medical Microbiology and Immunology2015
25903336Studies on the Contribution of Human Cytomegalovirus UL21a and UL97 to Viral Growth and Inactivation of the Anaphase-Promoting Complex/Cyclosome (APC/C) E3 Ubiquitin Ligase Reveal a Unique Cellular Mechanism for Downmodulation of the APC/C Subunits APC1,Journal of Virology2015
24526739IUGR and congenital cytomegalovirus infection.Journal of Infectious Diseases2014
24453373Human cytomegalovirus infection of human embryonic stem cell-derived primitive neural stem cells is restricted at several steps but leads to the persistence of viral DNA.J Virol2014
2418906925-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages.J Biol Chem2013
22013051High-resolution profiling and analysis of viral and host small RNAs during human cytomegalovirus infection.J Virol2012
22855486A mutation deleting sequences encoding the amino terminus of human cytomegalovirus UL84 impairs interaction with UL44 and capsid localization.Journal of Virology2012
22947141Inactivated HSV-2 in MPL/alum adjuvant provides nearly complete protection against genital infection and shedding following long term challenge and rechallenge.Vaccine2012
23055562Infection of vascular endothelial cells with human cytomegalovirus under fluid shear stress reveals preferential entry and spread of virus in flow conditions simulating atheroprone regions of the artery.J Virol2012
22234695Recombinant antibodies encoded by IGHV1-69 react with pUL32, a phosphoprotein of cytomegalovirus and B-cell superantigen.Blood2012
21865379Mutation of glutamine to arginine at position 548 of IE2 86 in human cytomegalovirus leads to decreased expression of IE2 40, IE2 60, UL83, and UL84 and increased transcription of US8-9 and US29-32.J Virol2011
21270160Immunization with herpes simplex virus 2 (HSV-2) genes plus inactivated HSV-2 is highly protective against acute and recurrent HSV-2 disease.Journal of Virology2011
20200242Human cytomegalovirus IE2 86 and IE2 40 proteins differentially regulate UL84 protein expression posttranscriptionally in the absence of other viral gene products.Journal of Virology2010
20686030Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.J Virol2010
20042513Proteasome subunits relocalize during human cytomegalovirus infection, and proteasome activity is necessary for efficient viral gene transcription.Journal of Virology2010
19297489Recruitment of cdk9 to the immediate-early viral transcriptosomes during human cytomegalovirus infection requires efficient binding to cyclin T1, a threshold level of IE2 86, and active transcription.Journal of Virology2009
18637510Subversion of cell cycle regulatory pathways.Current Topics in Microbiology and Immunology2008
17942546Accumulation of substrates of the anaphase-promoting complex (APC) during human cytomegalovirus infection is associated with the phosphorylation of Cdh1 and the dissociation and relocalization of APC subunits.Journal of Virology2008
17942543Inhibition of the cyclin-dependent kinases at the beginning of human cytomegalovirus infection specifically alters the levels and localization of the RNA polymerase II carboxyl-terminal domain kinases cdk9 and cdk7 at the viral transcriptosome.Journal of Virology2008
18463148Development of cell lines that provide tightly controlled temporal translation of the human cytomegalovirus IE2 proteins for complementation and functional analyses of growth-impaired and nonviable IE2 mutant viruses.Journal of Virology2008
18787008Internal deletions of IE2 86 and loss of the late IE2 60 and IE2 40 proteins encoded by human cytomegalovirus affect the levels of UL84 protein but not the amount of UL84 mRNA or the loading and distribution of the mRNA on polysomes.Journal of Virology2008
17715235Nuclear export of the human cytomegalovirus tegument protein pp65 requires cyclin-dependent kinase activity and the Crm1 exporter.Journal of Virology2007
17507492DNA immunization using highly conserved murine cytomegalovirus genes encoding homologs of human cytomegalovirus UL54 (DNA polymerase) and UL105 (helicase) elicits strong CD8 T-cell responses and is protective against systemic challenge.Journal of Virology2007
17983268A human cytomegalovirus-encoded microRNA regulates expression of multiple viral genes involved in replication.PLoS Pathog2007
17202222The IE2 60-kilodalton and 40-kilodalton proteins are dispensable for human cytomegalovirus replication but are required for efficient delayed early and late gene expression and production of infectious virus.Journal of Virology2007
16517745Genome-wide analysis reveals a highly diverse CD8 T cell response to murine cytomegalovirus.Journal of Immunology2006
17005673Repression of HMGA2 gene expression by human cytomegalovirus involves the IE2 86-kilodalton protein and is necessary for efficient viral replication and inhibition of cyclin A transcription.Journal of Virology2006
16731927Cyclin-dependent kinase activity is required for efficient expression and posttranslational modification of human cytomegalovirus proteins and for production of extracellular particles.Journal of Virology2006
16306619Human cytomegalovirus infection induces specific hyperphosphorylation of the carboxyl-terminal domain of the large subunit of RNA polymerase II that is associated with changes in the abundance, activity, and localization of cdk9 and cdk7.Journal of Virology2005
15919900Exon 3 of the human cytomegalovirus major immediate-early region is required for efficient viral gene expression and for cellular cyclin modulation.Journal of Virology2005
15596812Systemic priming-boosting immunization with a trivalent plasmid DNA and inactivated murine cytomegalovirus (MCMV) vaccine provides long-term protection against viral replication following systemic or mucosal MCMV challenge.Journal of Virology2005
14747546Small internal deletions in the human cytomegalovirus IE2 gene result in nonviable recombinant viruses with differential defects in viral gene expression.Journal of Virology2004
15452241Cyclin-dependent kinase activity is required at early times for accurate processing and accumulation of the human cytomegalovirus UL122-123 and UL37 immediate-early transcripts and at later times for virus production.Journal of Virology2004
15452242Multiple epitopes in the murine cytomegalovirus early gene product M84 are efficiently presented in infected primary macrophages and contribute to strong CD8+-T-lymphocyte responses and protection following DNA immunization.Journal of Virology2004
14645578Mechanisms governing maintenance of Cdk1/cyclin B1 kinase activity in cells infected with human cytomegalovirus.Journal of Virology2003
12551974Human cytomegalovirus infection leads to accumulation of geminin and inhibition of the licensing of cellular DNA replication.Journal of Virology2003
12516060Viral induction of site-specific chromosome damage.Reviews in Medical Virology2003
11991965Infection of cells with human cytomegalovirus during S phase results in a blockade to immediate-early gene expression that can be overcome by inhibition of the proteasome.Journal of Virology2002
11836387Strong CD8 T-cell responses following coimmunization with plasmids expressing the dominant pp89 and subdominant M84 antigens of murine cytomegalovirus correlate with long-term protection against subsequent viral challenge.Journal of Virology2002
11967299Development of a vaccine against murine cytomegalovirus (MCMV), consisting of plasmid DNA and formalin-inactivated MCMV, that provides long-term, complete protection against viral replication.Journal of Virology2002
12161637Virology. CMV makes a timely exit.Science2002
11861863Viable human cytomegalovirus recombinant virus with an internal deletion of the IE2 86 gene affects late stages of viral replication.Journal of Virology2002
11384228The use of recombinant baculoviruses for sustained expression of human cytomegalovirus immediate early proteins in fibroblasts.Virology2001
10639169Specific chromosome 1 breaks induced by human cytomegalovirus.Proceedings of the National Academy of Sciences of the United States of America2000
  • 1 - 50 of 131

Recommended Authors

Collaborators

Co-authored papers 17
Co-authored papers 7
Co-authored papers 4
University of California
Co-authored papers 4
The Scripps Research Institute
Co-authored papers 3
University of California San Diego
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
Center for AIDS Research, University of California San Diego
Co-authored papers 2
UPMC Hillman Cancer Center, University of Pittsburgh Medical Center
Co-authored papers 2
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
University of California
Co-authored papers 1
Co-authored papers 1
College of Veterinary Medicine, Washington State University
Co-authored papers 1
Oregon Health and Science University
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
The Roslin Institute, The University of Edinburgh
Co-authored papers 1
Co-authored papers 1
Michigan State University College of Human Medicine
Co-authored papers 1
MedImpact Healthcare Systems, Inc.
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1