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Author Details

Michele A Kutzler
Drexel University College of Medicine
2004
55
23
PMIDPaper TitleJournal TitlePublished Year
36805684Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals.Commun Biol2023
37885158Using the power of innate immunoprofiling to understand vaccine design, infection, and immunity.Hum Vaccin Immunother2023
36999023Adenosine deaminase augments SARS-CoV-2 specific cellular and humoral responses in aged mouse models of immunization and challenge.Front Immunol2023
35202770An old problem with new solutions: Strategies to improve vaccine efficacy in the elderly.Adv Drug Deliv Rev2022
35750334Improved Durability to SARS-CoV-2 Vaccine Immunity following Coimmunization with Molecular Adjuvant Adenosine Deaminase-1.J Immunol2022
35849213Aging alters antiviral signaling pathways resulting in functional impairment in innate immunity in response to pattern recognition receptor agonists.Geroscience2022
36380763Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals.Res Sq2022
35061851Pre-vaccination frequency of circulatory Tfh is associated with robust immune response to TV003 dengue vaccine.PLoS Pathog2022
33280624Hospital-acquired <i>Clostridioides difficile</i> infection among patients at an urban safety-net hospital in Philadelphia: Demographics, neighborhood deprivation, and the transferability of national statistics.Infect Control Hosp Epidemiol2021
33569701The impact of immuno-aging on SARS-CoV-2 vaccine development.Geroscience2021
34298152Development and clinical validation of an automated cell cytotoxicity neutralization assay for detecting Clostridioides difficile toxins in clinically relevant stools samples.Anaerobe2021
34204725Peptide Triazole Thiol Irreversibly Inactivates Metastable HIV-1 Env by Accessing Conformational Triggers Intrinsic to Virus-Cell Entry.Microorganisms2021
32280045Adenosine deaminase-1 enhances germinal center formation and functional antibody responses to HIV-1 Envelope DNA and protein vaccines.Vaccine2020
32057572CCR10 expression is required for the adjuvant activity of the mucosal chemokine CCL28 when delivered in the context of an HIV-1 Env DNA vaccine.Vaccine2020
31942789Metastable HIV-1 Surface Protein Env Sensitizes Cell Membranes to Transformation and Poration by Dual-Acting Virucidal Entry Inhibitors.Biochemistry2020
32837491Nonthermal plasma as part of a novel strategy for vaccination.Plasma Process Polym2020
32973779The 2020 Pandemic: Current SARS-CoV-2 Vaccine Development.Front Immunol2020
29767965Bifunctional Chimera That Coordinately Targets Human Immunodeficiency Virus 1 Envelope gp120 and the Host-Cell CCR5 Coreceptor at the Virus-Cell Interface.J Med Chem2018
30648120Defensive Driving: Directing HIV-1 Vaccine-Induced Humoral Immunity to the Mucosa with Chemokine Adjuvants.J Immunol Res2018
29430306A Pilot Study of Immune Activation and Rifampin Absorption in HIV-Infected Patients without Tuberculosis Infection: A Short Report.Tuberc Res Treat2017
28469517A Little Help From the Follicles: Understanding the Germinal Center Response to Human Immunodeficiency Virus 1 Infection and Prophylactic Vaccines.Clin Med Insights Pathol2017
25943275Chemokine-adjuvanted electroporated DNA vaccine induces substantial protection from simian immunodeficiency virus vaginal challenge.Mucosal Immunol2016
27250739Urine colorimetry to detect Low rifampin exposure during tuberculosis therapy: a proof-of-concept study.BMC Infect Dis2016
24401274Neuronal ferritin heavy chain and drug abuse affect HIV-associated cognitive dysfunction.J Clin Invest2014
25424943Strong HCV NS3/4a, NS4b, NS5a, NS5b-specific cellular immune responses induced in Rhesus macaques by a novel HCV genotype 1a/1b consensus DNA vaccine.Hum Vaccin Immunother2014
25024365An optimized, synthetic DNA vaccine encoding the toxin A and toxin B receptor binding domains of Clostridium difficile induces protective antibody responses in vivo.Infect Immun2014
22894954Non-contact helium-based plasma for delivery of DNA vaccines. Enhancement of humoral and cellular immune responses.Hum Vaccin Immunother2012
23111167DNA-based HIV vaccines do not induce generalized activation in mucosal tissue T cells.Hum Vaccin Immunother2012
23151454Generation of antigen-specific immunity following systemic immunization with DNA vaccine encoding CCL25 chemokine immunoadjuvant.Hum Vaccin Immunother2012
20952659Opioid-induced chemokine expression requires NF-κB activity: the role of PKCζ.J Leukoc Biol2011
21701683Long-term programming of antigen-specific immunity from gene expression signatures in the PBMC of rhesus macaques immunized with an SIV DNA vaccine.PLoS One2011
21264298Novel peptides based on HIV-1 gp120 sequence with homology to chemokines inhibit HIV infection in cell culture.PLoS One2011
21195801High antibody and cellular responses induced to HIV-1 clade C envelope following DNA vaccines delivered by electroporation.Vaccine2011
19847203Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo.Gene Ther2010
20188250Systemic immunization with CCL27/CTACK modulates immune responses at mucosal sites in mice and macaques.Vaccine2010
19530914Plasmid-encoded interleukin-15 receptor alpha enhances specific immune responses induced by a DNA vaccine in vivo.Hum Gene Ther2009
22573974Ultra-fast low concentration detection of Candida pathogens utilizing high resolution micropore chips.Sensors (Basel)2009
19683780High dose of plasmid IL-15 inhibits immune responses in an influenza non-human primates immunogenicity model.Virology2009
19497647Coimmunization with an optimized IL15 plasmid adjuvant enhances humoral immunity via stimulating B cells induced by genetically engineered DNA vaccines expressing consensus JEV and WNV E DIII.Vaccine2009
18252865DAMGO-induced expression of chemokines and chemokine receptors: the role of TGF-beta1.J Leukoc Biol2008
19372954Treatment interruption as a tool to measure changes in immunologic response to HIV-1.Curr Opin HIV AIDS2008
18753858Sustained suppression of SHIV89.6P replication in macaques by vaccine-induced CD8+ memory T cells.AIDS2008
18781156DNA vaccines: ready for prime time?Nat Rev Genet2008
18575608Heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus DNA antigens.PLoS One2008
17235321Enhanced cellular immune responses elicited by an engineered HIV-1 subtype B consensus-based envelope DNA vaccine.Mol Ther2007
18000037Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid.Proc Natl Acad Sci U S A2007
17584075Epitope-driven TB vaccine development: a streamlined approach using immuno-informatics, ELISpot assays, and HLA transgenic mice.Curr Mol Med2007
17335943Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease progression following SHIV(89.6P) challenge in rhesus macaques.Vaccine2007
16157426Mapping of immune responses following wild-type and mutant ABeta42 plasmid or peptide vaccination in different mouse haplotypes and HLA Class II transgenic mice.Vaccine2006
16763607Regression of subcutaneous B16 melanoma tumors after intratumoral delivery of an IL-15-expressing plasmid followed by in vivo electroporation.Cancer Gene Ther2006
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Collaborators

Wistar Institute
Co-authored papers 29
Co-authored papers 4
Center for Natural Products Research, University of Havana
Co-authored papers 3
The Janssen Pharmaceutical Companies of Johnson & Johnson
Co-authored papers 3
University of Georgia
Co-authored papers 3
University of Colorado - Anschutz Medical Campus
Co-authored papers 2
Co-authored papers 2
EpiVax Inc.
Co-authored papers 2
Co-authored papers 2
Dana-Farber Cancer Institute, Harvard Medical School
Co-authored papers 2
University of Massachusetts Medical School
Co-authored papers 1
Co-authored papers 1
University of Washington
Co-authored papers 1
University of Washington
Co-authored papers 1
Center for Innate Immunity and Immune Disease, University of Washington
Co-authored papers 1
Pathology Advanced Translational Research Unit, Emory University School of Medicine
Co-authored papers 1
The Wistar Institute
Co-authored papers 1
University of Texas Medical Branch
Co-authored papers 1
Co-authored papers 1
University of Washington
Co-authored papers 1
Vaccine and Gene Therapy Institute, Oregon Health and Science University
Co-authored papers 1
Co-authored papers 1
University of Pennsylvania
Co-authored papers 1
University of Arizona Center on Aging, University of Arizona
Co-authored papers 1
Institute for Social Science Research, The University of Queensland
Co-authored papers 1
University of Massachusetts Chan Medical School
Co-authored papers 1
University of Texas San Antonio
Co-authored papers 1
Co-authored papers 1
Clinical Research Division, Fred Hutchinson Cancer Research Center
Co-authored papers 1
Brigham and Women's Hospital
Co-authored papers 1