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Author Details

Gosia Trynka
Wellcome Sanger Institute
2008
67
39
Nathan Sheffield (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36376339Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia.Sci Rep2022
35610203Robust temporal map of human in vitro myelopoiesis using single-cell genomics.Nat Commun2022
35618845Immune disease risk variants regulate gene expression dynamics during CD4<sup>+</sup> T cell activation.Nat Genet2022
36243721Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells.Nat Commun2022
33958779Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney.Nat Genet2021
31591516Immunochip meta-analysis in European and Argentinian populations identifies two novel genetic loci associated with celiac disease.Eur J Hum Genet2020
33223527Genomic profiling of T-cell activation suggests increased sensitivity of memory T cells to CD28 costimulation.Genes Immun2020
33293539Functional studies of GWAS variants are gaining momentum.Nat Commun2020
33206176Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney.Eur Heart J2020
32477401From GWAS to Function: Using Functional Genomics to Identify the Mechanisms Underlying Complex Diseases.Front Genet2020
32149610The single-cell eQTLGen consortium.Elife2020
32499651A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by T<sub>reg</sub> cells.Nature2020
32286271Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4<sup>+</sup> T cells to cytokines.Nat Commun2020
31548716Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases.Nat Genet2019
30356220Gene expression variability across cells and species shapes innate immunity.Nature2018
29873782Coloc-stats: a unified web interface to perform colocalization analysis of genomic features.Nucleic Acids Res2018
28658209Fine-mapping inflammatory bowel disease loci to single-variant resolution.Nature2017
28166213Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.Nat Genet2017
29074944Enhancers looping to target genes.Nat Genet2017
28718505Immunogenomic approaches to understand the function of immune disease variants.Immunology2017
25966632Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes.Eur J Hum Genet2016
26546613Functional implications of disease-specific variants in loci jointly associated with coeliac disease and rheumatoid arthritis.Hum Mol Genet2016
27102333The influence of a short-term gluten-free diet on the human gut microbiome.Genome Med2016
27052111Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.Nat Commun2016
25920553Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci.Eur J Hum Genet2016
25052311Evaluation of European coeliac disease risk variants in a north Indian population.Eur J Hum Genet2015
26414678Partitioning heritability by functional annotation using genome-wide association summary statistics.Nat Genet2015
26405070Contrasting the Genetic Background of Type 1 Diabetes and Celiac Disease Autoimmunity.Diabetes Care2015
26422229Tissue-Specific Enrichment of Lymphoma Risk Loci in Regulatory Elements.PLoS One2015
26140449Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci.Am J Hum Genet2015
25894500Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease.Nat Genet2015
25447851Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus.Gastroenterology2015
23704318Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants.Gut2014
25439723Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases.Am J Hum Genet2014
24997987Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia.Nat Genet2014
24968232Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells.PLoS Genet2014
24520335Integration of sequence data from a Consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene.PLoS One2014
24550294Convergent evolution in European and Rroma populations reveals pressure exerted by plague on Toll-like receptors.Proc Natl Acad Sci U S A2014
24334606Fine mapping of the celiac disease-associated LPP locus reveals a potential functional variant.Hum Mol Genet2014
24390342Genetics of rheumatoid arthritis contributes to biology and drug discovery.Nature2014
23696630A genetic variant in the region of MMP-9 is associated with serum levels and progression of joint damage in rheumatoid arthritis.Ann Rheum Dis2014
23263488Chromatin marks identify critical cell types for fine mapping complex trait variants.Nat Genet2013
24287333Using chromatin marks to interpret and localize genetic associations to complex human traits and diseases.Curr Opin Genet Dev2013
23459209ImmunoChip study implicates antigen presentation to T cells in narcolepsy.PLoS Genet2013
23555300Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis.PLoS Genet2013
22446960Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis.Nat Genet2012
22961001Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus.Nat Genet2012
23143596High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.Nat Genet2012
21298027A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease.PLoS Genet2011
22057235Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease.Nat Genet2011
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Collaborators

Cisca Wijmenga
Co-authored papers 35
Alexandra Zhernakova
Co-authored papers 23
Lude Franke
Co-authored papers 19
Soumya Raychaudhuri
Brigham and Women's Hospital and Harvard Medical School
Co-authored papers 16
Panos Deloukas
William Harvey Research Institute, Queen Mary University of London
Co-authored papers 8
Tom W J Huizinga
Co-authored papers 8
Peter K Gregersen
Co-authored papers 8
Eli A Stahl
Co-authored papers 8
René E M Toes
Co-authored papers 7
Robert M Plenge
Co-authored papers 7
Dorothée Diogo
Co-authored papers 6
Suna Onengut-Gumuscu
Co-authored papers 6
Lara Bossini-Castillo
Departamento de Genetica e Instituto de Biotecnologia, Universidad de Granada
Co-authored papers 6
Stephen S Rich
Co-authored papers 6
Vinod Kumar
The University of Queensland
Co-authored papers 5
Barbara E Stranger
Center for Genetic Medicine, Northwestern University Feinberg School of Medicine
Co-authored papers 5
Sarah E Hunt
European Bioinformatics Institute
Co-authored papers 5
Paul I W de Bakker
Vertex Pharmaceuticals
Co-authored papers 5
Jane Worthington
Co-authored papers 5
Marieke J H Coenen
Co-authored papers 5
Sarah Edkins
Co-authored papers 4
Philip L De Jager
Columbia University Medical Center
Co-authored papers 4
Katherine A Siminovitch
University of Toronto, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 4
Lars Klareskog
Co-authored papers 4
Mark J Daly
Massachusetts General Hospital
Co-authored papers 4
Jeffrey C Barrett
Co-authored papers 4
Leonid Padyukov
Co-authored papers 4
Patrick Deelen
Co-authored papers 4
Anne Barton
Co-authored papers 4
Piet L C M van Riel
Co-authored papers 4
Release 1.2