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Author Details

Nael A McCarty
Emory University
1990
83
30
PMIDPaper TitleJournal TitlePublished Year
36096204Exacerbation-prone pediatric asthma is associated with arginine, lysine, and methionine pathway alterations.J Allergy Clin Immunol2023
37544654Mathematical models of cystic fibrosis as a systemic disease.WIREs Mech Dis2023
37351179A transistor model for the cystic fibrosis transmembrane conductance regulator.Biophys Rep (N Y)2023
37014352Tweaking the catalytic efficiency of the CFTR ion channel.J Gen Physiol2023
34957709Bacteriophage-Loaded Poly(lactic-co-glycolic acid) Microparticles Mitigate Staphylococcus aureus Infection and Cocultures of Staphylococcus aureus and Pseudomonas aeruginosa.Adv Healthc Mater2022
36425670Permissive and nonpermissive channel closings in CFTR revealed by a factor graph inference algorithm.Biophys Rep (N Y)2022
34163370Alteration of Membrane Cholesterol Content Plays a Key Role in Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Channel Activity.Front Physiol2021
33877622Electrophysiological Approaches for the Study of Ion Channel Function.Methods Mol Biol2021
33877620Reconstitution of Detergent-Solubilized Membrane Proteins into Proteoliposomes and Nanodiscs for Functional and Structural Studies.Methods Mol Biol2021
33724301Breathe-Your immune system is counting on it.J Exp Med2021
34647973The molecular evolution of function in the CFTR chloride channel.J Gen Physiol2021
34382377Sphingomyelinase decreases transepithelial anion secretion in airway epithelial cells in part by inhibiting CFTR-mediated apical conductance.Physiol Rep2021
34514718Mechanistic analysis and significance of sphingomyelinase-mediated decreases in transepithelial CFTR currents in nHBEs.Physiol Rep2021
31621328Early Detection of Cystic Fibrosis Acute Pulmonary Exacerbations by Exhaled Breath Condensate Metabolomics.J Proteome Res2020
32313074The bidirectional relationship between CFTR and lipids.Commun Biol2020
30921517ATP-Dependent Signaling in Simulations of a Revised Model of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).J Phys Chem B2019
31679858An Ancient CFTR Ortholog Informs Molecular Evolution in ABC Transporters.Dev Cell2019
31530897VX-770-mediated potentiation of numerous human CFTR disease mutants is influenced by phosphorylation level.Sci Rep2019
28887112Protein and lipid interactions - Modulating CFTR trafficking and rescue.J Cyst Fibros2018
30854250Inhaled bacteriophage-loaded polymeric microparticles ameliorate acute lung infections.Nat Biomed Eng2018
28657312Molecular Dynamics Flexible Fitting Simulations Identify New Models of the Closed State of the Cystic Fibrosis Transmembrane Conductance Regulator Protein.J Chem Inf Model2017
28364225Comparison of Ambient and Atmospheric Pressure Ion Sources for Cystic Fibrosis Exhaled Breath Condensate Ion Mobility-Mass Spectrometry Metabolomics.J Am Soc Mass Spectrom2017
28213469Insulin signaling via the PI3-kinase/Akt pathway regulates airway glucose uptake and barrier function in a CFTR-dependent manner.Am J Physiol Lung Cell Mol Physiol2017
28152602Feasibility of Early Detection of Cystic Fibrosis Acute Pulmonary Exacerbations by Exhaled Breath Condensate Metabolomics: A Pilot Study.J Proteome Res2017
29044184Zebrafish aversive taste co-receptor is expressed in both chemo- and mechanosensory cells and plays a role in lateral line development.Sci Rep2017
28542304The "new normal": Adapting doctoral trainee career preparation for broad career paths in science.PLoS One2017
28592822Bacterial Sphingomyelinase is a State-Dependent Inhibitor of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR).Sci Rep2017
28686703Correction: The "new normal": Adapting doctoral trainee career preparation for broad career paths in science.PLoS One2017
26817932Advanced glycation end products are elevated in cystic fibrosis-related diabetes and correlate with worse lung function.J Cyst Fibros2016
26610860A longitudinal analysis of chronic MRSA and Pseudomonas aeruginosa co-infection in cystic fibrosis: A single-center study.J Cyst Fibros2016
27781088Ability of device to collect bacteria from cough aerosols generated by adults with cystic fibrosis.F1000Res2016
27288484Potentiators exert distinct effects on human, murine, and Xenopus CFTR.Am J Physiol Lung Cell Mol Physiol2016
26684250Positioning of extracellular loop 1 affects pore gating of the cystic fibrosis transmembrane conductance regulator.Am J Physiol Lung Cell Mol Physiol2016
26115671Junctional abnormalities in human airway epithelial cells expressing F508del CFTR.Am J Physiol Lung Cell Mol Physiol2015
26209275Murine and human CFTR exhibit different sensitivities to CFTR potentiators.Am J Physiol Lung Cell Mol Physiol2015
24097557Hyperglycemia impedes lung bacterial clearance in a murine model of cystic fibrosis-related diabetes.Am J Physiol Lung Cell Mol Physiol2014
25762501Inflammation and ER stress downregulate BDH2 expression and dysregulate intracellular iron in macrophages.J Immunol Res2014
25024266Three charged amino acids in extracellular loop 1 are involved in maintaining the outer pore architecture of CFTR.J Gen Physiol2014
22657751Formulation of meningococcal capsular polysaccharide vaccine-loaded microparticles with robust innate immune recognition.J Microencapsul2013
24086355Modeling the conformational changes underlying channel opening in CFTR.PLoS One2013
23838697Peripheral monocytes derived from patients with cystic fibrosis and healthy donors secrete NGAL in response to Pseudomonas aeruginosa infection.J Investig Med2013
24019192Ion mobility and liquid chromatography/mass spectrometry strategies for exhaled breath condensate glucose quantitation in cystic fibrosis studies.Rapid Commun Mass Spectrom2013
23709221Two salt bridges differentially contribute to the maintenance of cystic fibrosis transmembrane conductance regulator (CFTR) channel function.J Biol Chem2013
23578801Origin and evolution of the cystic fibrosis transmembrane regulator protein R domain.Gene2013
22160394Differential contribution of TM6 and TM12 to the pore of CFTR identified by three sulfonylurea-based blockers.Pflugers Arch2012
22973307Pyoverdine, the Major Siderophore in Pseudomonas aeruginosa, Evades NGAL Recognition.Interdiscip Perspect Infect Dis2012
22879944Relating the disease mutation spectrum to the evolution of the cystic fibrosis transmembrane conductance regulator (CFTR).PLoS One2012
21228336Low abundance of sweat duct Cl- channel CFTR in both healthy and cystic fibrosis athletes with exceptionally salty sweat during exercise.Am J Physiol Regul Integr Comp Physiol2011
21813870High-sweat Na+ in cystic fibrosis and healthy individuals does not diminish thirst during exercise in the heat.Am J Physiol Regul Integr Comp Physiol2011
20150590A novel bioassay for detecting GPCR heterodimerization: transactivation of beta 2 adrenergic receptor by bradykinin receptor.J Biomol Screen2010
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Collaborators

Michael Koval
Emory University School of Medicine
Co-authored papers 6
Kirsten A Cottrill
Emory University
Co-authored papers 5
Facundo M Fern??ndez
Georgia Institute of Technology
Co-authored papers 4
Katherine A Cottrill
Emory University
Co-authored papers 3
Stephen C Harvey
University of Pennsylvania
Co-authored papers 2
Susan O Kim
Emory University
Co-authored papers 1
Ahmad F Mohammad
Emory University
Co-authored papers 1
Anne M Fitzpatrick
Emory University
Co-authored papers 1
Neha Varghese
Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory
Co-authored papers 1
James C Gumbart
Georgia Institute of Technology
Co-authored papers 1
Joshua D Chandler
Emory University School of Medicine, USA Center for CF & Airways Disease Research
Co-authored papers 1
Susan T Stephenson
Emory University
Co-authored papers 1
Rishikesan Kamaleswaran
Duke University, Emory University, Society for Critical Care Medicine, University of Ontario Institute of Technology, University of Tennessee Health Science Center
Co-authored papers 1
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