Skip to Main Content

Author Details

Johnathon N Lakins
University of California san francisco
1992
46
30
Kirsten Obernier (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
38017076Author Correction: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.Nat Med2024
37016139Author Correction: Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression.Nat Cell Biol2023
37503095Tissue tension permits β-catenin phosphorylation to drive mesoderm specification in human embryonic stem cells.bioRxiv2023
37322009A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer.Nat Commun2023
35896617Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer.Oncogene2022
35618935Screening of organoids derived from patients with breast cancer implicates the repressor NCOR2 in cytotoxic stress response and antitumor immunity.Nat Cancer2022
33822843Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer.J Exp Med2021
32721948Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217.J Clin Invest2020
33207224Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells.Dev Cell2020
31511693Controlled modelling of human epiblast and amnion development using stem cells.Nature2019
31609314Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics.J Vis Exp2019
29431617Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma.Mol Cancer Res2018
29805991Genetically Encoded Toolbox for Glycocalyx Engineering: Tunable Control of Cell Adhesion, Survival, and Cancer Cell Behaviors.ACS Biomater Sci Eng2018
30202050A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma.Nat Cell Biol2018
29980625Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells.J Cell Biol2018
28381423Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix.Mol Biol Cell2017
27089513Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.Nat Med2016
26342256Monitoring developmental force distributions in reconstituted embryonic epithelia.Methods2016
27820599Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression.Nat Cell Biol2016
27452175Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation.Cell Stem Cell2016
25435379A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype.J Biotechnol2015
26337386Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors.Mol Biol Cell2015
23770848Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin.Oncogene2014
25030168The cancer glycocalyx mechanically primes integrin-mediated growth and survival.Nature2014
24633304Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression.Nat Med2014
23618955A physical sciences network characterization of non-tumorigenic and metastatic cells.Sci Rep2013
22914951Exploring the link between human embryonic stem cell organization and fate using tension-calibrated extracellular matrix functionalized polyacrylamide gels.Methods Mol Biol2012
20389018HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype.J Clin Invest2010
19931152Matrix crosslinking forces tumor progression by enhancing integrin signaling.Cell2009
17911169alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini.J Cell Sci2007
16169468Tensional homeostasis and the malignant phenotype.Cancer Cell2005
14691145Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors.J Cell Biol2003
11772027Evidence that clusterin has discrete chaperone and ligand binding sites.Biochemistry2002
12242153beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium.Cancer Cell2002
11803476Expression of multiple forms of clusterin during light-induced retinal degeneration.Curr Eye Res2001
11282398An antigen capture assay for the measurement of serum clusterin concentrations.J Biochem Biophys Methods2001
10601611Expression and regulation of estrogen receptor beta in human breast tumors and cell lines.Oncol Rep2000
11059746Expression and function of CYR61, an angiogenic factor, in breast cancer cell lines and tumor biopsies.Cancer Res2000
9774400Clusterin biogenesis is altered during apoptosis in the regressing rat ventral prostate.J Biol Chem1998
9796610Clusterin in the male reproductive tract.J Androl1998
9336835Identification and characterization of glycosylation sites in human serum clusterin.Protein Sci1997
8723115Differential display RT PCR of total RNA from human foreskin fibroblasts for investigation of androgen-dependent gene expression.Am J Med Genet1996
76724445 alpha-Reductase type 1 is localized to the outer nuclear membrane.Mol Cell Endocrinol1995
8181474Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration.Eur J Biochem1994
7680346Genomic organization and expression of the rat TRPM-2 (clusterin) gene, a gene implicated in apoptosis.J Biol Chem1993
1356648Active cell death in hormone-dependent tissues.Cancer Metastasis Rev1992
  • 1 - 46 of 46

Recommended Authors

Aditya Kumar
Rice University, University of California San Diego
Career Start Year 2013
Number of shared co-authors 1
Kevin M Tharp
University of California berkeley
Career Start Year 2011
Number of shared co-authors 4
Laurent Fattet
Moores Cancer Center, University of California
Career Start Year 2011
Number of shared co-authors 0
Shannon K Alford
National Cancer Institute
Career Start Year 2004
Number of shared co-authors 0
Hon S Leong
University of Toronto
Career Start Year 2002
Number of shared co-authors 0
Trevor D McKee
University Health Network
Career Start Year 2001
Number of shared co-authors 0
Val??rie Petit
INSERM U1021, Institut Curie, PSL Research University, Campus Universitaire
Career Start Year 1999
Number of shared co-authors 0
Jianjun Shen
The University of Texas MD Anderson Cancer Center
Career Start Year 1998
Number of shared co-authors 0
Dongquan Chen
University of Alabama at Birmingham
Career Start Year 1997
Number of shared co-authors 1
Michael T Lewis
Baylor College of Medicine
Career Start Year 1996
Number of shared co-authors 2
Kaylene J Simpson
The University of Melbourne, Peter MacCallum Cancer Centre
Career Start Year 1996
Number of shared co-authors 0
Alexander D Borowsky
University of California Davis Health
Career Start Year 1995
Number of shared co-authors 2
Karen H Martin
West Virginia University Cancer Institute, West Virginia University
Career Start Year 1993
Number of shared co-authors 0
Charles A Whittaker
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Career Start Year 1993
Number of shared co-authors 1
Senthil K Muthuswamy
Center for Cancer Research, National Cancer Institute, National Institutes of Health
Career Start Year 1992
Number of shared co-authors 2
Donna J Webb
Vanderbilt University
Career Start Year 1991
Number of shared co-authors 0
Roger Chammas
Instituto do Cancer do Estado de Sao Paulo, Faculdade de Medicina de Sao Paulo
Career Start Year 1989
Number of shared co-authors 1
Stephen M Hewitt
Center for Cancer Research, National Cancer Institute
Career Start Year 1988
Number of shared co-authors 2
Michael R Freeman
Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
Career Start Year 1987
Number of shared co-authors 0
Louis Gaboury
Institute for Research in Immunology and Cancer (IRIC), University of Montreal
Career Start Year 1986
Number of shared co-authors 0
Charles R Vanderburg
Massachusetts General Hospital and Harvard Medical School
Career Start Year 1986
Number of shared co-authors 0
Beatrice S Knudsen
University of Utah
Career Start Year 1986
Number of shared co-authors 1
Jeffrey L Wrana
Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital
Career Start Year 1985
Number of shared co-authors 0
Rama Khokha
Princess Margaret Cancer Centre, University Health Network
Career Start Year 1984
Number of shared co-authors 0
Simon C Watkins
Center for Molecular Imaging, University of Pittsburgh School of Medicine
Career Start Year 1981
Number of shared co-authors 0
Mary C Farach-Carson
The University of Texas Health Science Center at Houston School of Dentistry
Career Start Year 1981
Number of shared co-authors 0
Alan Rick Horwitz
Allen Institute for Cell Science
Career Start Year 1977
Number of shared co-authors 0
Anne E Cress
University of Arizona Cancer Center, College of Medicine, University of Arizona
Career Start Year 1977
Number of shared co-authors 0
Kathleen A Burke
Brown University
Career Start Year 1975
Number of shared co-authors 0
Richard O Hynes
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Career Start Year 1970
Number of shared co-authors 1

Collaborators

Valerie M Weaver
University of California san francisco
Co-authored papers 32
Laralynne Przybyla
University of California san francisco
Co-authored papers 4
Joanna J Phillips
University of California san francisco
Co-authored papers 4
James M Barnes
Center for Bioengineering and Tissue Regeneration
Co-authored papers 4
Jonathon M Muncie
Gladstone Institutes
Co-authored papers 3
Colm Morrissey
Co-authored papers 3
FuiBoon Kai
University of California San Francisco
Co-authored papers 3
Anders I Persson
University of California san francisco
Co-authored papers 3
Russell Bainer
University of California berkeley
Co-authored papers 3
Kirk C Hansen
University of Colorado Anschutz Medical Campus
Co-authored papers 3
Alexander S Barrett
University of Colorado Anschutz Medical Campus
Co-authored papers 3
Ori Maller
Department of Research and Development, Inc.
Co-authored papers 2
Eric A Collisson
University of California san francisco
Co-authored papers 2
Jianping Fu
College of life sciences, Jiangxi Normal university
Co-authored papers 2
Carolyn R Bertozzi
Stanford University
Co-authored papers 2
Barbara L Weber
Basser Center for BRCA, Abramson Cancer Center, University of Pennsylvania
Co-authored papers 1
Wadih Arap
Rutgers Cancer Institute of New Jersey
Co-authored papers 1
Peter Kuhn
University of Tubingen
Co-authored papers 1
Catherine C Park
University of California san francisco
Co-authored papers 1
Tyler Jacks
Co-authored papers 1
Jason C Tung
University of California san francisco
Co-authored papers 1
Steven A Carr
Broad Institute of MIT and Harvard
Co-authored papers 1
Denis Wirtz
Johns Hopkins University
Co-authored papers 1
Joseph E Aslan
Oregon Health & Science University
Co-authored papers 1
Gabriele Bergers
VIB-Center for Cancer Biology
Co-authored papers 1
William A Weiss
University of California san francisco
Co-authored papers 1
Jayanta Debnath
University of California San Francisco
Co-authored papers 1
Kan V Lu
Clinical Medical Research Center of Hepatic Surgery at Hubei Province
Co-authored papers 1
Richard Bonneau
Center for Computational Biology (CCB), Flatiron Institute, Simons Foundation
Co-authored papers 1
Shelly Kaushik
Invictus Oncology Pvt. Ltd.
Co-authored papers 1
Release 1.2