Author details

Full Name

Julius Brennecke

Affiliation

ORCID

Career Start Year

2002

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36604593	ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers.		2023
34718559	A genetic toolkit for studying transposon control in the Drosophila melanogaster ovary.	Genetics	2022
35173350	Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery.	Nat Struct Mol Biol	2022
33574069	Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex.	Genes Dev	2021
33191911	Structure of the human core transcription-export complex reveals a hub for multivalent interactions.	eLife	2020
32496553	A universal method for the rapid isolation of all known classes of functional silencing small RNAs.	Nucleic Acids Research	2020
33199607	Structure-function analysis of microRNA 3'-end trimming by Nibbler.	Proc Natl Acad Sci U S A	2020
31384064	The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation.	Nat Struct Mol Biol	2019
28847004	A heterochromatin-dependent transcription machinery drives piRNA expression.	Nature	2017
27851737	Genetic and mechanistic diversity of piRNA 3'-end formation.	Nature	2016
25977553	Noncoding RNA. piRNA-guided slicing specifies transcripts for Zucchini-dependent, phased piRNA biogenesis.	Science	2015
25805138	Pitfalls of mapping high-throughput sequencing data to repetitive sequences: Piwi's genomic targets still not identified.	Dev Cell	2015
26302790	piRNA-guided slicing of transposon transcripts enforces their transcriptional silencing via specifying the nuclear piRNA repertoire.	Genes and Development	2015
26494711	Silencio/CG9754 connects the Piwi-piRNA complex to the cellular heterochromatin machinery.	Genes and Development	2015
25081352	The exon junction complex is required for definition and excision of neighboring introns in Drosophila.	Genes and Development	2014
24906153	The rhino-deadlock-cutoff complex licenses noncanonical transcription of dual-strand piRNA clusters in Drosophila.	Cell	2014
23665231	The genetic makeup of the Drosophila piRNA pathway.	Molecular Cell	2013
23913922	Drosophila Gtsf1 is an essential component of the Piwi-mediated transcriptional silencing complex.	Genes and Development	2013
23159368	Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression.	Cell	2012
22902557	The cochaperone shutdown defines a group of biogenesis factors essential for all piRNA populations in Drosophila.	Molecular Cell	2012
23028068	Preparation of small RNA libraries for high-throughput sequencing.	Cold Spring Harbor Protocols	2012
21863019	A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors.	EMBO J	2011
21460824	A genome-scale shRNA resource for transgenic RNAi in Drosophila.	Nat Methods	2011
20818334	An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila.	EMBO J	2010
20934772	The piRNA pathway: a fly's perspective on the guardian of the genome.	Trends in Genetics	2010
19917252	Hierarchical rules for Argonaute loading in Drosophila.	Molecular Cell	2009
19635780	Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform.	RNA	2009
19395010	Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary.	Cell	2009
18394895	Temporal reciprocity of miRNAs and their targets during the maternal-to-zygotic transition in Drosophila.	Current Biology	2008
19039138	An epigenetic role for maternally inherited piRNAs in transposon silencing.	Science	2008
18560542	Perinatal androgens and adult behavior vary with nestling social system in siblicidal boobies.	PLoS ONE	2008
18463631	An endogenous small interfering RNA pathway in Drosophila.	Nature	2008
18229681	Analysis of large-scale sequencing of small RNAs.		2008
18172160	A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands.	Genes Dev	2008
17346786	Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila.	Cell	2007
17994088	Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures.	Nature	2007
17989255	Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes.	Genome Res	2007
17975059	The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race.	Science	2007
16581772	Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster.	Mol Cell Biol	2006
17043305	Denoising feedback loops by thresholding--a new role for microRNAs.	Genes and Development	2006
16601183	Developmental biology. Mixed messages in early development.	Science	2006
16337999	Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution.	Cell	2005
16204177	Not miR-ly muscular: microRNAs and muscle development.	Genes and Development	2005
15723116	Principles of microRNA-target recognition.	PLoS Biol	2005
14981248	Transportin2 functions as importin and mediates nuclear import of HuR.	Proceedings of the National Academy of Sciences of the United States of America	2004
14691535	Identification of Drosophila MicroRNA targets.	PLoS Biol	2003
12952528	Towards a complete description of the microRNA complement of animal genomes.		2003
12679032	bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila.	Cell	2003
12049770	Transrepression of AP-1 by nuclear receptors in Drosophila.	Mechanisms of Development	2002