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Author Details

Gerard Manning
Genentech Inc.
1991
70
52
PMIDPaper TitleJournal TitlePublished Year
36993163Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.bioRxiv2023
37551632Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.Biochem J2023
32374727The genomic landscape of metastatic breast cancer: Insights from 11,000 tumors.PLoS One2020
31553902Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3.Cell Rep2019
29382369HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors.Breast Cancer Res2018
28400531Genomics and evolution of protein phosphatases.Sci Signal2017
26996308Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2.Cancer Cell2016
26865533Necroptosis and Inflammation.Annu Rev Biochem2016
25485619A comprehensive transcriptional portrait of human cancer cell lines.Nat Biotechnol2015
26284514Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat.Database (Oxford)2015
26101579Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series.ACS Med Chem Lett2015
26110843Bioinformatics analysis of thousands of TCGA tumors to determine the involvement of epigenetic regulators in human cancer.BMC Genomics2015
26216984Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.Proc Natl Acad Sci U S A2015
25820941Key challenges for the creation and maintenance of specialist protein resources.Proteins2015
24107129A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.Biochem J2014
25423365The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima.PLoS Biol2014
25324391HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span.Science2014
24807215Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.Nat Commun2014
23293031Identification of a mammalian-type phosphatidylglycerophosphate phosphatase in the Eubacterium Rhodopirellula baltica.J Biol Chem2013
24327557Discovery of a metabolic alternative to the classical mevalonate pathway.Elife2013
23819521Assessment of computational methods for predicting the effects of missense mutations in human cancers.BMC Genomics2013
24012759Insulin biosynthetic interaction network component, TMEM24, facilitates insulin reserve pool release.Cell Rep2013
23942320The Capsaspora genome reveals a complex unicellular prehistory of animals.Nat Commun2013
23419129Premetazoan genome evolution and the regulation of cell differentiation in the choanoflagellate Salpingoeca rosetta.Genome Biol2013
22550341Genomic survey of premetazoans shows deep conservation of cytoplasmic tyrosine kinases and multiple radiations of receptor tyrosine kinases.Sci Signal2012
22900076The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteins.PLoS One2012
22922647RPN-6 determines C. elegans longevity under proteotoxic stress conditions.Nature2012
22622584Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis.Nature2012
21245385Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression.Mol Cell Biol2011
21795713Comparative analysis of Histophilus somni immunoglobulin-binding protein A (IbpA) with other fic domain-containing enzymes reveals differences in substrate and nucleotide specificities.J Biol Chem2011
21787419The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology.Genome Biol2011
21593603Programmed ribosomal frameshifting in the expression of the regulator of intestinal stem cell proliferation, adenomatous polyposis coli (APC).RNA Biol2011
21551031The Selaginella genome identifies genetic changes associated with the evolution of vascular plants.Science2011
21654194From Plk1 to Plk5: functional evolution of polo-like kinases.Cell Cycle2011
21730175Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis.Proc Natl Acad Sci U S A2011
21331044Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB.Nature2011
20077512Genomics, evolution, and crystal structure of a new family of bacterial spore kinases.Proteins2010
21144066How the vertebrates were made: selective pruning of a double-duplicated genome.BMC Biol2010
20686567The Amphimedon queenslandica genome and the evolution of animal complexity.Nature2010
20547848Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).Proc Natl Acad Sci U S A2010
20421470Nitrosopumilus maritimus genome reveals unique mechanisms for nitrification and autotrophy in globally distributed marine crenarchaea.Proc Natl Acad Sci U S A2010
19966789Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.Nat Chem Biol2010
19244117TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2.Cancer Res2009
19949461Short Promoters in Viral Vectors Drive Selective Expression in Mammalian Inhibitory Neurons, but do not Restrict Activity to Specific Inhibitory Cell-Types.Front Neural Circuits2009
19884882Cyclin-dependent kinases: a family portrait.Nat Cell Biol2009
19716789The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress.Mol Cell2009
19379521Amphioxus encodes the largest known family of green fluorescent proteins, which have diversified into distinct functional classes.BMC Evol Biol2009
19141289Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site.Structure2009
18273011The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans.Nature2008
18776889Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases.Nat Chem Biol2008
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Collaborators

Salk Institute for Biological Studies
Co-authored papers 6
ShanghaiTech University
Co-authored papers 5
University of California
Co-authored papers 5
University of California
Co-authored papers 4
National Center for Biotechnology Information, National Institutes of Health
Co-authored papers 3
TheScripps Research Institute
Co-authored papers 3
Universite Cote d'Azur, CNRS, Inserm
Co-authored papers 3
Howard Hughes Medical Institute, The University of California berkeley
Co-authored papers 3
Broad Institute of MIT and Harvard
Co-authored papers 3
University of Georgia
Co-authored papers 2
University of Maine
Co-authored papers 2
Baylor College of Medicine
Co-authored papers 2
CNRS, Sorbonne Universite
Co-authored papers 2
Co-authored papers 2
Tianjin Institute of Environmental and Operational Medicine
Co-authored papers 2
Baylor College of Medicine
Co-authored papers 2
Broad Institute of MIT and Harvard
Co-authored papers 2
Cellular and Developmental Biology and Marine Science Institute
Co-authored papers 2
Institut de Biologia Evolutiva (CSIC-Universitat Pompeu Fabra)
Co-authored papers 2
Sorbonne Universite, CNRS
Co-authored papers 2
University of New Orleans
Co-authored papers 2
Co-authored papers 2
University of California at San Diego
Co-authored papers 2
National Science Foundation
Co-authored papers 2
Boston University
Co-authored papers 2
US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory
Co-authored papers 2
McLean Hospital
Co-authored papers 2
Co-authored papers 2
David Geffen School of Medicine, University of California los angeles
Co-authored papers 2
Institut Biology Valrose, Universite Cote d'Azur
Co-authored papers 2