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Author Details

Scott D Rychnovsky
University of California irvine
1990
137
33
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36652389Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.Anal Chem2023
35235311Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.Anal Chem2022
35499304Asymmetric Total Synthesis of (2<i>R</i>)-Hydroxynorneomajucin, a Norsesquiterpene from <i>Illicium jiadifengpi</i>.Org Lett2022
35948006Discovery of compounds that reactivate p53 mutants in vitro and in vivo.Cell Chem Biol2022
35094508Total Syntheses of Strasseriolide A and B, Antimalarial Macrolide Natural Products.Org Lett2022
34349018Protein interaction landscapes revealed by advanced in vivo cross-linking-mass spectrometry.Proc Natl Acad Sci U S A2021
33635083Silacycle-Templated Intramolecular Diels-Alder Cyclizations for the Diastereoselective Construction of Complex Carbon Skeletons.Org Lett2021
33915260Enabling Photoactivated Cross-Linking Mass Spectrometric Analysis of Protein Complexes by Novel MS-Cleavable Cross-Linkers.Mol Cell Proteomics2021
32202417Exploring Spacer Arm Structures for Designs of Asymmetric Sulfoxide-Containing MS-Cleavable Cross-Linkers.Anal Chem2020
32034103Structural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling.Proc Natl Acad Sci U S A2020
32806106Using the Competing Enantioselective Conversion Method to Assign the Absolute Configuration of Cyclic Amines with Bode's Acylation Reagents.J Org Chem2020
30723094Probing H<sub>2</sub>O<sub>2</sub>-mediated Structural Dynamics of the Human 26S Proteasome Using Quantitative Cross-linking Mass Spectrometry (QXL-MS).Mol Cell Proteomics2019
31820648Relative and Absolute Structure Assignments of Alkenes Using Crystalline Osmate Derivatives for X-ray Analysis.Org Lett2019
31408328Total Synthesis and Structure Revision of (-)-Illisimonin A, a Neuroprotective Sesquiterpenoid from the Fruits of <i>Illicium simonsii</i>.J Am Chem Soc2019
31491044Total Synthesis of (-)-Himeradineâ¿¿A.Angew Chem Int Ed Engl2019
29792801Development of a Novel Sulfoxide-Containing MS-Cleavable Homobifunctional Cysteine-Reactive Cross-Linker for Studying Protein-Protein Interactions.Anal Chem2018
30192149Biosynthesis-Inspired Approach to Kujounin A<sub>2</sub> Using a Stereoselective Tsuji-Trost Alkylation.Org Lett2018
29943989Second-Generation Synthesis of (+)-Fastigiatine Inspired by Conformational Studies.J Org Chem2018
29938513Catalytic Enantioselective Allylations of Acetylenic Aldehydes via 2-Propanol-Mediated Reductive Coupling.Org Lett2018
29424546Heteroatom-Directed Acylation of Secondary Alcohols To Assign Absolute Configuration.J Org Chem2018
28763223Determination of the Absolute Configuration of Cyclic Amines with Bode's Chiral Hydroxamic Esters Using the Competing Enantioselective Conversion Method.Org Lett2017
28292943Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome.Mol Cell Proteomics2017
28508638Determination of the Absolute Configuration of β-Chiral Primary Alcohols Using the Competing Enantioselective Conversion Method.Org Lett2017
28821611The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress.J Biol Chem2017
27579766Route to Highly Substituted Pyridines.J Org Chem2016
28966768Concise synthesis of (+)-fastigiatine.Chem Sci2016
27786473Generation, Stability, and Utility of Lithium 4,4'-Di-tert-butylbiphenylide (LiDBB).J Org Chem2016
27626298Developing a Multiplexed Quantitative Cross-Linking Mass Spectrometry Platform for Comparative Structural Analysis of Protein Complexes.Anal Chem2016
27565113Distinct mechanisms underlying cholesterol protection against alcohol-induced BK channel inhibition and resulting vasoconstriction.Biochim Biophys Acta2016
27295460Stereoselection in Intramolecular Diels-Alder Reactions of 2-Cyano-1-azadienes: Indolizidine and Quinolizidine Synthesis.Org Lett2016
27417384Developing an Acidic Residue Reactive and Sulfoxide-Containing MS-Cleavable Homobifunctional Cross-Linker for Probing Protein-Protein Interactions.Anal Chem2016
27415613Nanomole-Scale Assignment and One-Use Kits for Determining the Absolute Configuration of Secondary Alcohols.J Org Chem2016
25475042Generation, structure and reactivity of tertiary organolithium reagents.Nat Prod Rep2015
26632597Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8.Nat Commun2015
26269432Design of CID-cleavable protein cross-linkers: identical mass modifications for simpler sequence analysis.Org Biomol Chem2015
26365187Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis.Cell Rep2015
26087830Stereochemical Outcomes in Reductive Cyclizations To Form Spirocyclic Heterocycles.Org Lett2015
25823605Synthesis of two new enrichable and MS-cleavable cross-linkers to define protein-protein interactions by mass spectrometry.Org Biomol Chem2015
24471733Developing new isotope-coded mass spectrometry-cleavable cross-linkers for elucidating protein structures.Anal Chem2014
25200563Silyl enol ether Prins cyclization: diastereoselective formation of substituted tetrahydropyran-4-ones.J Org Chem2014
25253489A new in vivo cross-linking mass spectrometry platform to define protein-protein interactions in living cells.Mol Cell Proteomics2014
24456289Studies toward the synthesis of palhinine lycopodium alkaloids: a Morita-Baylis-Hillman/intramolecular Diels-Alder approach.Org Lett2014
23323958Absolute configuration of lactams and oxazolidinones using kinetic resolution catalysts.Org Lett2013
24128066Kinetic analysis of the HBTM-catalyzed esterification of an enantiopure secondary alcohol.Org Lett2013
23962271Formation of highly substituted tetrahydropyranones: application to the total synthesis of cyanolide A.Org Lett2013
23954590Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response.Dev Cell2013
23594129Trianion synthon approach to spirocyclic heterocycles.Org Lett2013
23593963Determination of absolute configuration of secondary alcohols using thin-layer chromatography.J Org Chem2013
23477601Origins of regio- and stereochemistry in type 2 intramolecular N-acylnitroso Diels-Alder reactions: a computational study of tether length and substituent effects.J Org Chem2013
22413935Total synthesis of lepadiformine alkaloids using N-Boc α-amino nitriles as trianion synthons.J Org Chem2012
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Collaborators

Lan Huang
University of California Irvine
Co-authored papers 22
Clinton Yu
University of California Irvine
Co-authored papers 18
Eric J Novitsky
University of California irvine
Co-authored papers 8
Xiaorong Wang
University of California Irvine
Co-authored papers 7
Alexander S Huszagh
University of California irvine
Co-authored papers 6
Craig B Gutierrez
University of California irvine
Co-authored papers 5
Robyn M Kaake
J. David Gladstone Institutes
Co-authored papers 4
Yingying Yang
University of California irvine
Co-authored papers 4
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 3
Rosa Viner
University of California (Davis)
Co-authored papers 3
Ilan E Chemmama
University of California san francisco
Co-authored papers 3
Sarah A Block
University of California irvine
Co-authored papers 3
Ning Zheng
University of Washington
Co-authored papers 2
Haibin Mao
University of Washington Howard Hughes Medical Institute, University of Washington
Co-authored papers 2
Peter Cimermancic
Verily Life Sciences LLC
Co-authored papers 2
Ruedi Aebersold
Institute of Molecular Systems Biology, ETH Zurich
Co-authored papers 1
Ignacia Echeverria
University of California san francisco
Co-authored papers 1
Yue Xu
South China University of Technology
Co-authored papers 1
Peter A Kollman
Co-authored papers 1
Rommie E Amaro
University of California
Co-authored papers 1
Yihong Ye
National Institute of Diabetes, National Institutes of Health
Co-authored papers 1
Eri Sakata
Max Planck Institute of Biochemistry
Co-authored papers 1
Abdullah Kahraman
University of Zurich
Co-authored papers 1
Paolo Nanni
Functional Genomics Center Zurich (FGCZ)-University of Zurich/ETH Zurich
Co-authored papers 1
Florian Beck
Max Planck Institute of Biochemistry
Co-authored papers 1
Xing Guo
Life Sciences Institute, Zhejiang University
Co-authored papers 1
Wolfgang Baumeister
Max Planck Institute of Biochemistry
Co-authored papers 1
Piotr Cieplak
Sanford-Burnham-Prebys Medical Discovery Institute
Co-authored papers 1
Nikita Chopra
Schrodinger Inc.
Co-authored papers 1
Charles H Greenberg
University of California San Francisco
Co-authored papers 1
Release 1.2