Author details

Full Name

James A Wells

Affiliation

Department of Pharmaceutical Chemistry, University of California San Francisco

ORCID

Career Start Year

1974

Papers

242

H Index

Expertise

CM4AI Collaborator

Andrej Sali (CM4AI)

PMID	Paper Title	Journal Title	Published Year
34410115	Biotin as a Reactive Handle to Selectively Label Proteins and DNA with Small Molecules.	ACS Chem Biol	2022
36454758	MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas.	Proc Natl Acad Sci U S A	2022
35217172	Hypoxia Is a Dominant Remodeler of the Effector TÂ Cell Surface Proteome Relative to Activation and Regulatory T Cell Suppression.	Mol Cell Proteomics	2022
35212540	Engineering Antibodies Targeting p16 MHC-Peptide Complexes.	ACS Chem Biol	2022
35210365	Switchable assembly and function of antibody complexes inÂ vivo using a small molecule.	Proc Natl Acad Sci U S A	2022
35027731	BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.	Nat Cell Biol	2022
35166238	Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers.	J Clin Invest	2022
35104453	Identifying and antagonizing the interactions between layilin and glycosylated collagens.	Cell Chem Biol	2022
33395526	Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1.	J Am Chem Soc	2021
33767397	Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection.	Nat Biotechnol	2021
33483421	Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy.	Proc Natl Acad Sci U S A	2021
33536314	Mapping proteolytic neo-N termini at the surface of living cells.	Proc Natl Acad Sci U S A	2021
33666135	Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2.	MAbs	2021
33501440	BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.	bioRxiv	2021
33833059	Reply to Liu et al.: Specific mutations matter in specificity and catalysis in ACE2.	Proc Natl Acad Sci U S A	2021
34616392	Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance.	Front Immunol	2021
34570183	Cleavage of talin by calpain promotes platelet-mediated fibrin clot contraction.	Blood Adv	2021
34090922	Inhibition of Cancer Cell Adhesion, Migration and Proliferation by a Bispecific Antibody that Targets two Distinct Epitopes on Î±v Integrins.	J Mol Biol	2021
34330834	A functional mammalian display screen identifies rare antibodies that stimulate NK cell-mediated cytotoxicity.	Proc Natl Acad Sci U S A	2021
34330709	SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay.	Sci Adv	2021
32163288	National Cancer Institute Think-Tank Meeting Report on Proteomic Cartography and Biomarkers at the Single-Cell Level: Interrogation of Premalignant Lesions.	J Proteome Res	2020
31663725	Subtiligase-Catalyzed Peptide Ligation.	Chem Rev	2020
32074409	N-Terminal Modification of Proteins with Subtiligase Specificity Variants.	Curr Protoc Chem Biol	2020
31792071	Profiling the Surfaceome Identifies Therapeutic Targets for Cells with Hyperactive mTORC1 Signaling.	Mol Cell Proteomics	2020
33093202	Engineered ACE2 receptor traps potently neutralize SARS-CoV-2.	Proc Natl Acad Sci U S A	2020
32973096	Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries.	Proc Natl Acad Sci U S A	2020
32943149	Split enzymes: Design principles and strategy.	Methods Enzymol	2020
32938700	Competitive SARS-CoV-2 Serology Reveals Most Antibodies Targeting the Spike Receptor-Binding Domain Compete for ACE2 Binding.	mSphere	2020
32766586	Engineered ACE2 receptor traps potently neutralize SARS-CoV-2.	bioRxiv	2020
32924468	Targeting Phosphotyrosine in Native Proteins with Conditional, Bispecific Antibody Traps.	J Am Chem Soc	2020
32839788	Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection.	medRxiv	2020
32341034	Theranostic Targeting of CUB Domain Containing Protein 1 (CDCP1) in Pancreatic Cancer.	Clin Cancer Res	2020
32413285	Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering.	Cell Chem Biol	2020
32205440	Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes.	Proc Natl Acad Sci U S A	2020
30584089	Multiomics of azacitidine-treated AML cells reveals variable and convergent targets that remodel the cell-surface proteome.	Proc Natl Acad Sci U S A	2019
31221560	Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration.	Neuron	2019
31274316	Kinase Atlas: Druggability Analysis of Potential Allosteric Sites in Kinases.	J Med Chem	2019
28970360	Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades.	Mol Cancer Res	2018
30080377	The Unique Cofactor Region of Zika Virus NS2B-NS3 Protease Facilitates Cleavage of Key Host Proteins.	ACS Chem Biol	2018
30127017	Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators.	Proc Natl Acad Sci U S A	2018
29877794	An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.	Elife	2018
30398859	Engineering Improved Antiphosphotyrosine Antibodies Based on an Immunoconvergent Binding Motif.	J Am Chem Soc	2018
29476010	Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies.	Proc Natl Acad Sci U S A	2018
29362479	Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.	Cell Death Differ	2018
29359686	Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins.	Elife	2018
29569925	Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates.	Mol Pharm	2018
29155430	Engineering peptide ligase specificity by proteomic identification of ligation sites.	Nat Chem Biol	2018
29200207	Human antibody-based chemically induced dimerizers for cell therapeutic applications.	Nat Chem Biol	2018
28919041	A Split-Abl Kinase for Direct Activation in Cells.	Cell Chem Biol	2017
28170244	Structure-Activity Relationship and Molecular Mechanics Reveal the Importance of Ring Entropy in the Biosynthesis and Activity of a Natural Product.	J Am Chem Soc	2017

1 - 50 of 242

Nir London

The Weizmann Institute of Science

Career Start Year 2007

Number of shared co-authors 9

Almer M van der Sloot

Institute for Research in Immunology and Cancer, Universite de Montreal

Career Start Year 2003

Number of shared co-authors 3

Alan M Sandercock

MedImmune Ltd.

Career Start Year 2001

Number of shared co-authors 1

Marc C Deller

Incyte Corporation

Career Start Year 2000

Number of shared co-authors 2

Udupi A Ramagopal

Poornaprajna Institute of Scientific Research (PPISR)

Career Start Year 1998

Number of shared co-authors 1

Eric Feyfant

Schrodinger Inc.

Career Start Year 1997

Number of shared co-authors 1

Pavel Strop

Pfizer Inc.

Career Start Year 1997

Number of shared co-authors 5

Shira Albeck

Weizmann Institute of Science

Career Start Year 1996

Number of shared co-authors 6

Orly Dym

Weizmann Institute of Science

Career Start Year 1995

Number of shared co-authors 6

Bj??rn G Voldborg

Technical University of Denmark

Career Start Year 1995

Number of shared co-authors 1

Jaume Pons

Pfizer Inc.

Career Start Year 1994

Number of shared co-authors 5

James C Whisstock

Monash University

Career Start Year 1994

Number of shared co-authors 1

Tom W Muir

Princeton University

Career Start Year 1993

Number of shared co-authors 6

Petr Nov??k

Institute of Microbiology of the CAS

Career Start Year 1991

Number of shared co-authors 3

Steven C Almo

Albert Einstein College of Medicine

Career Start Year 1988

Number of shared co-authors 14

Raymond C Stevens

iHuman Institute, ShanghaiTech University

Career Start Year 1988

Number of shared co-authors 11

Roman Jerala

National Institute of Chemistry

Career Start Year 1988

Number of shared co-authors 1

Miriam Eisenstein

Weizmann Institute of Science

Career Start Year 1988

Number of shared co-authors 7

David E Timm

Lilly Research Laboratories

Career Start Year 1988

Number of shared co-authors 2

Rob Hooft van Huijsduijnen

Vrije Universiteit Amsterdam (VU)

Career Start Year 1987

Number of shared co-authors 1

Raymond J Owens

University of Oxford

Career Start Year 1986

Number of shared co-authors 6

Mark R Chance

Case Western Reserve University

Career Start Year 1986

Number of shared co-authors 9

Stanley R Krystek

Bristol-Myers Squibb Pharmaceutical Research Institute

Career Start Year 1985

Number of shared co-authors 4

Stefan Knapp

Institute of Pharmaceutical Chemistry, Goethe University

Career Start Year 1983

Number of shared co-authors 10

Tamar Unger

Weizmann Institute of Science

Career Start Year 1983

Number of shared co-authors 6

Ronald T Raines

Massachusetts Institute of Technology

Career Start Year 1981

Number of shared co-authors 0

Gianni Cesareni

University of Rome 'Tor Vergata'

Career Start Year 1976

Number of shared co-authors 1

Tom L Blundell

Heartand Lung Research Institute, University of Cambridge

Career Start Year 1971

Number of shared co-authors 2

Robert J Fletterick

University of California San Francisco

Career Start Year 1971

Number of shared co-authors 10

Wayne A Hendrickson

Columbia University

Career Start Year 1968

Number of shared co-authors 4

row(s) 1 - 30 of 30

Irene Lui

Department of Pharmaceutical Chemistry, University of California san francisco

Co-authored papers 9

Sachdev S Sidhu

School of Pharmacy, University of Waterloo

Co-authored papers 7

Sami Mahrus

Department of Pharmaceutical Chemistry, University of California san francisco

Co-authored papers 7

Terry J Rettenmaier

University of California san francisco

Co-authored papers 7

Arun P Wiita

University of California San Francisco

Co-authored papers 7

Jonathan S Weissman

Whitehead Institute for Biomedical Research

Co-authored papers 6

Alma L Burlingame

Department of Pharmaceutical Chemistry, University of California san francisco

Co-authored papers 6

Andrej Sali (CM4AI)

University of California San Francisco

Co-authored papers 4

Tanja Kortemme

University of California san francisco

Co-authored papers 4

Bruce R Conklin

Gladstone Institutes

Co-authored papers 3

Martin Kampmann

Institute for Neurodegenerative Diseases, University of California san francisco

Co-authored papers 3

Jonathan C Trinidad

Indiana University

Co-authored papers 3

Adam R Renslo

Department of Pharmaceutical Chemistry, University of California san francisco

Co-authored papers 3

Matthew P Jacobson

Department of Pharmaceutical Chemistry, University of California san francisco

Co-authored papers 3

Michael J Romanowski

Sunesis Pharmaceuticals, Inc. 395 Oyster Point Boulevard

Co-authored papers 3

Shane Atwell

Lilly Research Laboratories

Co-authored papers 3

Timothy J Henrich

University of California san francisco

Co-authored papers 3

Emily D Crawford

Co-authored papers 3

Allison K Doak

Department of Pharmaceutical Chemistry, University of California San Francisco

Co-authored papers 3

Jason Moffat

University of Toronto

Co-authored papers 2

Gordon Whiteley

Co-authored papers 2

Jennifer Oki

Synthego Corporation

Co-authored papers 2

Avi J Samelson

Institute for Neurodegenerative Diseases, University of California san francisco

Co-authored papers 2

Oren S Rosenberg

University of California san francisco

Co-authored papers 2

Jared Carlson-Stevermer

Synthego Corporation

Co-authored papers 2

Travis J Maures

University of Michigan Medical School ann arbor

Co-authored papers 2

Charles Y Chiu

University of California-San Francisco

Co-authored papers 2

Marco Vignuzzi

Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)

Co-authored papers 2

Charles L Brooks

University of Michigan ann arbor

Co-authored papers 2

Karl R Clauser

Co-authored papers 2

1 - 30

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