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Author Details

Heather R Christofk
Jonsson Comprehensive Cancer Center, University of California los angeles
2004
75
40
PMIDPaper TitleJournal TitlePublished Year
37640283Acute activation of adipocyte lipolysis reveals dynamic lipid remodeling of the hepatic lipidome.J Lipid Res2024
38070508Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy.Cell2024
36773955Fumarate Hydratase Variants and Their Association With Paraganglioma/Pheochromocytoma.Urology2023
37682999Vitamin B<sub>6</sub> is governed by the local compartmentalization of metabolic enzymes during growth.Sci Adv2023
37815914MYC is a regulator of androgen receptor inhibition-induced metabolic requirements in prostate cancer.Cell Rep2023
37255402FH Variant Pathogenicity Promotes Purine Salvage Pathway Dependence in Kidney Cancer.Cancer Discov2023
37086408ZFP36-mediated mRNA decay regulates metabolism.Cell Rep2023
37260407Nutrient regulation of development and cell fate decisions.Development2023
34724198Fumarate hydratase variant prevalence and manifestations among individuals receiving germline testing.Cancer2022
36411320Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells.Nat Cancer2022
36179695TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids.Stem Cell Reports2022
34138729Targeting nucleotide metabolism as the nexus of viral infections, cancer, and the immune response.Sci Adv2021
33883682GLUT1 overexpression enhances glucose metabolism and promotes neonatal heart regeneration.Sci Rep2021
33767183SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition.Nat Commun2021
33534563Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss.J Med Chem2021
33667361Challenges in Studying Stem Cell Metabolism.Cell Stem Cell2021
33609439Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth.Cell Metab2021
34547228More Metabolism!Mol Cell2021
34414571Metabolic decisions in development and disease-a Keystone Symposia report.Ann N Y Acad Sci2021
34161263Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas.Proc Natl Acad Sci U S A2021
32359707Metabolic Regulation of Tissue Stem Cells.Trends Cell Biol2020
31896820Publisher Correction: In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer.Nature2020
33275887O-Mg! Lactate Drives Mg<sup>2+</sup> Mobilization.Mol Cell2020
32861192Glioblastoma Utilizes Fatty Acids and Ketone Bodies for Growth Allowing Progression during Ketogenic Diet Therapy.iScience2020
32726636GSK3 Inhibits Macropinocytosis and Lysosomal Activity through the Wnt Destruction Complex Machinery.Cell Rep2020
30827860Differential Metabolic Reprogramming by Zika Virus Promotes Cell Death in Human versus Mosquito Cells.Cell Metab2019
31666695In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer.Nature2019
32694817The next decade of metabolism.Nat Metab2019
31319842Viral hijacking of cellular metabolism.BMC Biol2019
29106930Topical Inhibition of the Electron Transport Chain Can Stimulate the Hair Cycle.J Invest Dermatol2018
29985359Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue.J Vis Exp2018
30197082Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization.Cell2018
29692895Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities.Cancer Metab2018
29763624The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma.Cancer Cell2018
28607481Cell cycle: Division enzyme regulates metabolism.Nature2017
28099841Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer.Cell Rep2017
28202506Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures.Mol Syst Biol2017
29231167Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis.Elife2017
28812582Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism.Nat Cell Biol2017
28812580Lactate dehydrogenase activity drives hair follicle stem cell activation.Nat Cell Biol2017
28648777mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.Mol Cell2017
26876179MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4.Cell Rep2016
27618217Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State.Cell Stem Cell2016
27146673Epigenetic changes mediated by polycomb repressive complex 2 and E2a are associated with drug resistance in a mouse model of lymphoma.Genome Med2016
27126896Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor.Nat Commun2016
25468909Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression.J Biol Chem2015
26561297MYC-induced reprogramming of glutamine catabolism supports optimal virus replication.Nat Commun2015
26612572Rethinking glutamine addiction.Nat Cell Biol2015
261906512-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.Cell Metab2015
25956888Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy.J Cell Sci2015
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Collaborators

Lewis C Cantley
Co-authored papers 9
Blake R Wilde
University of California los angeles
Co-authored papers 6
Steven M Dubinett
David Geffen School of Medicine at university of california los angeles
Co-authored papers 6
Laurent Vergnes
Co-authored papers 5
Siavash K Kurdistani
David Geffen School of Medicine, University of California los angeles
Co-authored papers 5
Paul S Mischel
Stanford University
Co-authored papers 5
Karen Reue
Co-authored papers 5
Michael C Fishbein
Co-authored papers 4
Nicholas A Graham
University of Southern California
Co-authored papers 4
Peter J Mullen
University of St Andrews
Co-authored papers 4
Edward D Esplin
Invitae Corporation
Co-authored papers 3
Hilary A Coller
Co-authored papers 3
Timothy F Cloughesy
David Geffen School of Medicine, University of California Los Angeles
Co-authored papers 3
Orian S Shirihai
David Geffen School of Medicine (L.S., University of California los angeles
Co-authored papers 3
Brian Shuch
University of California los angeles
Co-authored papers 3
David Jelinek
Co-authored papers 3
Karen Ouyang
Invitae Corporation
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Paul C Boutros
University of California los angeles
Co-authored papers 3
Matteo Pellegrini
Co-authored papers 3
William B Tu
David Geffen School of Medicine, University of California Los Angeles
Co-authored papers 2
Jason W Locasale
Duke University
Co-authored papers 2
Bin Zheng
Co-authored papers 2
Kym F Faull
Co-authored papers 2
Kathryn E Hatchell
Invitae Corporation
Co-authored papers 2
Eric Lu
David Geffen School of Medicine at university of california los angeles
Co-authored papers 2
Edward B Garon
David Geffen School of Medicine, University of California Los Angeles
Co-authored papers 2
Joshua D Rabinowitz
Lewis Sigler Institute for Integrative Genomics, Princeton University
Co-authored papers 2
Sarah M Nielsen
Invitae Corporation
Co-authored papers 2
Costas A Lyssiotis
Co-authored papers 2
Markus Ralser
Charite - Universitatsmedizin Berlin
Co-authored papers 2
Release 1.2