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Author Details

Luke Alphey
The Pirbright Institute
1989
158
43
PMIDPaper TitleJournal TitlePublished Year
36670107Closing the gap to effective gene drive in Aedes aegypti by exploiting germline regulatory elements.Nat Commun2023
37669371Mimicking superinfection exclusion disrupts alphavirus infection and transmission in the yellow fever mosquito <i>Aedes aegypti</i>.Proc Natl Acad Sci U S A2023
37990055AePUb promoter length modulates gene expression in Aedes aegypti.Sci Rep2023
37985762CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus.Nat Commun2023
37811374Optimizing CRE and PhiC31 mediated recombination in <i>Aedes aegypti</i>.Front Bioeng Biotechnol2023
37398284CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector <i>Culex quinquefasciatus</i>.bioRxiv2023
35180218Considerations for homology-based DNA repair in mosquitoes: Impact of sequence heterology and donor template source.PLoS Genet2022
35737714Intron-derived small RNAs for silencing viral RNAs in mosquito cells.PLoS Negl Trop Dis2022
35535033Reproductive interference and Satyrisation: mechanisms, outcomes and potential use for insect control.J Pest Sci (2004)2022
35419354The Challenges in Developing Efficient and Robust Synthetic Homing Endonuclease Gene Drives.Front Bioeng Biotechnol2022
35746799Expression of Alphavirus Nonstructural Protein 2 (nsP2) in Mosquito Cells Inhibits Viral RNA Replication in Both a Protease Activity-Dependent and -Independent Manner.Viruses2022
36414618A CRISPR endonuclease gene drive reveals distinct mechanisms of inheritance bias.Nat Commun2022
35867566The Acquisition and Retention of Lumpy Skin Disease Virus by Blood-Feeding Insects Is Influenced by the Source of Virus, the Insect Body Part, and the Time since Feeding.J Virol2022
36121880Daisy-chain gene drives: The role of low cut-rate, resistance mutations, and maternal deposition.PLoS Genet2022
36343250Silencing RNAs expressed from W-linked <i>PxyMasc</i> "retrocopies" target that gene during female sex determination in <i>Plutella xylostella</i>.Proc Natl Acad Sci U S A2022
35285719Toward a CRISPR-Cas9-Based Gene Drive in the Diamondback Moth <i>Plutella xylostella</i>.CRISPR J2022
33357053Genetic pest management and the background genetics of release strains.Philos Trans R Soc Lond B Biol Sci2021
33660916Engineered expression of the invertebrate-specific scorpion toxin AaHIT reduces adult longevity and female fecundity in the diamondback moth Plutella xylostella.Pest Manag Sci2021
34414615CRISPR/Cas9-based functional characterization of the pigmentation gene ebony in Plutella xylostella.Insect Mol Biol2021
34834923Innate Immune Antagonism of Mosquito-Borne Flaviviruses in Humans and Mosquitoes.Viruses2021
34294769CRISPR/Cas-9 mediated knock-in by homology dependent repair in the West Nile Virus vector Culex quinquefasciatus Say.Sci Rep2021
34319783nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity.J Virol2021
34282149Combating mosquito-borne diseases using genetic control technologies.Nat Commun2021
33159350Satyrization in Drosophila fruitflies.J Evol Biol2021
32129976Expanding the CRISPR Toolbox in Culicine Mosquitoes: <i>In Vitro</i> Validation of Pol III Promoters.ACS Synth Biol2020
31793118Identification and characterization of a Masculinizer homologue in the diamondback moth, Plutella xylostella.Insect Mol Biol2020
33335055Core commitments for field trials of gene drive organisms.Science2020
33270627Targeting female flight for genetic control of mosquitoes.PLoS Negl Trop Dis2020
33239631Split drive killer-rescue provides a novel threshold-dependent gene drive.Sci Rep2020
33208534Opinion: Standardizing the definition of gene drive.Proc Natl Acad Sci U S A2020
32917146Ommochrome pathway genes kynurenine 3-hydroxylase and cardinal participate in eye pigmentation in Plutella xylostella.BMC Mol Cell Biol2020
32886709Cross-utilisation of template RNAs by alphavirus replicases.PLoS Pathog2020
32737398Cas13b-dependent and Cas13b-independent RNA knockdown of viral sequences in mosquito cells following guide RNA expression.Commun Biol2020
32908596Population-level multiplexing: A promising strategy to manage the evolution of resistance against gene drives targeting a neutral locus.Evol Appl2020
32283279Identification and characterization of the vasa gene in the diamondback moth, Plutella xylostella.Insect Biochem Mol Biol2020
32523938Genetic Biocontrol for Invasive Species.Front Bioeng Biotechnol2020
31479450Engineered action at a distance: Blood-meal-inducible paralysis in Aedes aegypti.PLoS Negl Trop Dis2019
31714905CRISPR/Cas9 gene editing in the West Nile Virus vector, Culex quinquefasciatus Say.PLoS One2019
31217251Design and Use of Chikungunya Virus Replication Templates Utilizing Mammalian and Mosquito RNA Polymerase I-Mediated Transcription.J Virol2019
31260669Modeling the mutation and reversal of engineered underdominance gene drives.J Theor Biol2019
29570717Population dynamics of engineered underdominance and killer-rescue gene drives in the control of disease vectors.PLoS Comput Biol2018
30190331Recent advances in threshold-dependent gene drives for mosquitoes.Biochem Soc Trans2018
27871673Is It Time for Synthetic Biodiversity Conservation?Trends Ecol Evol2017
28728996Conditions for success of engineered underdominance gene drive systems.J Theor Biol2017
28620268Towards the genetic control of invasive species.Biol Invasions2017
27027400Insect transformation with piggyBac: getting the number of injections just right.Insect Mol Biol2016
33579149Similar vertical transmission rates of dengue and chikungunya viruses in a transgenic and a non-transformed Aedes aegypti (L.) laboratory strain.Trop Biomed2016
27643991SIT 2.0: 21(st) Century genetic technology for the screwworm sterile-insect program.BMC Biol2016
27871244Identification of genes for engineering the male germline of Aedes aegypti and Ceratitis capitata.BMC Genomics2016
26849518Can CRISPR-Cas9 gene drives curb malaria?Nat Biotechnol2016
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Collaborators

Anthony A James
University of California irvine
Co-authored papers 7
Sanjay Basu
The Pirbright Institute
Co-authored papers 7
Omar S Akbari
University of California
Co-authored papers 5
J M Axton
Whitehead Institute
Co-authored papers 4
Antoinette J Piaggio
National Wildlife Research Center
Co-authored papers 3
Valentino M Gantz
University of California San Diego
Co-authored papers 3
Jason L Rasgon
The Pennsylvania State University, University Park
Co-authored papers 2
John M Marshall
School of Public Health, UC Berkeley
Co-authored papers 2
Philippos Aris Papathanos
The Hebrew University of Jerusalem
Co-authored papers 2
Owain R Edwards
Macquarie University
Co-authored papers 2
Fred Gould
North Carolina State University
Co-authored papers 2
Janet Hemingway
London School of Hygiene & Tropical Medicine
Co-authored papers 2
Koen Bartholomeeusen
Institute of Tropical Medicine
Co-authored papers 2
Zach N Adelman
Texas A&M University, College Station
Co-authored papers 2
J Royden Saah
Co-authored papers 2
Kenneth A Oye
Massachusetts Institute of Technology
Co-authored papers 1
Craig Montell
University of California santa barbara
Co-authored papers 1
Peter Tompa
VIB-VUB Center for Structural Biology
Co-authored papers 1
Larisa Rudenko
Massachusetts Institute of Technology
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Stephanie Gamez
University of California
Co-authored papers 1
Eduardo Massad
University of Sao Paulo and LIM01-HCFMUSP
Co-authored papers 1
Jennifer Kuzma
North Carolina State University
Co-authored papers 1
Claudia Emerson
Institute on Ethics and Policy for Innovation, McMaster University
Co-authored papers 1
Sam Weiss Evans
Co-authored papers 1
Cinnamon Bloss
University of California
Co-authored papers 1
Robert M Friedman
J. Craig Venter Institute
Co-authored papers 1
Maxwell J Scott
North Carolina State University
Co-authored papers 1
James P Collins
Arizona State University
Co-authored papers 1
Jolene T Sutton
University of Hawai'i at Hilo
Co-authored papers 1
Robert D C Saunders
The Open University
Co-authored papers 1
Release 1.2