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Author Details

Laszlo Urban
Matrahaza University and Teaching Hospital
1981
169
50
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36223558Five-Year Survival Outcomes With Nivolumab Plus Ipilimumab Versus Chemotherapy as First-Line Treatment for Metastatic Non-Small-Cell Lung Cancer in CheckMate 227.J Clin Oncol2023
37468498A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.Nat Commun2023
36725084First-line nivolumab plus ipilimumab for metastatic non-small cell lung cancer, including patients with ECOG performance status 2 and other special populations: CheckMate 817.J Immunother Cancer2023
34648948First-Line Nivolumab Plus Ipilimumab in Advanced NSCLC: 4-Year Outcomes From the Randomized, Open-Label, Phase 3 CheckMate 227 Part 1 Trial.J Thorac Oncol2022
33082101Major Clinical Response to Afatinib Monotherapy in Lung Adenocarcinoma Harboring EGFR Exon 20 Insertion Mutation.Clin Lung Cancer2021
33791693Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2.bioRxiv2021
33483756Cardiotoxic Potential of Hydroxychloroquine, Chloroquine and Azithromycin in Adult Human Primary Cardiomyocytes.Toxicol Sci2021
35002544Increase in the Length of Lung Cancer Patient Pathway Before First-Line Therapy: A 6-Year Nationwide Analysis From Hungary.Pathol Oncol Res2021
34406891Formation of a novel supraspinal-spinal connectome that relearns the same motor task after complete paralysis.J Neurophysiol2021
34326236Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2.Science2021
32565027Machine learning guided association of adverse drug reactions with in vitro target-based pharmacology.EBioMedicine2020
32703874The activities of drug inactive ingredients on biological targets.Science2020
32872120Efficacy of Incremental Next-Generation ALK Inhibitor Treatment in Oncogene-Addicted, <i>ALK</i>-Positive, <i>TP53</i>-Mutant NSCLC.J Pers Med2020
32340676Lung Cancer in Hungary.J Thorac Oncol2020
30244081Safety differentiation: emerging competitive edge in drug development.Drug Discov Today2019
27557833Rolapitant improves quality of life of patients receiving highly or moderately emetogenic chemotherapy.Support Care Cancer2017
28461256Smoking History Predicts Sensitivity to PARP Inhibitor Veliparib in Patients with Advanced Non-Small Cell Lung Cancer.J Thorac Oncol2017
28794167REPLY TO THORNELOE ET AL.Physiol Rev2017
28786378Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets.Elife2017
27803064Randomized, Placebo-Controlled, Phase II Study of Veliparib in Combination with Carboplatin and Paclitaxel for Advanced/Metastatic Non-Small Cell Lung Cancer.Clin Cancer Res2017
26975508Implications of Dynamic Occupancy, Binding Kinetics, and Channel Gating Kinetics for hERG Blocker Safety Assessment and Mitigation.Curr Top Med Chem2016
27653550Spatial Distribution of the Cannabinoid Type 1 and Capsaicin Receptors May Contribute to the Complexity of Their Crosstalk.Sci Rep2016
27140035Secondary pharmacology: screening and interpretation of off-target activities - focus on translation.Drug Discov Today2016
27252279TRPV4: Molecular Conductor of a Diverse Orchestra.Physiol Rev2016
26022402Integrated risk assessment of suicidal ideation and behavior in drug development.Drug Discov Today2015
26272769Safety and efficacy of rolapitant for prevention of chemotherapy-induced nausea and vomiting after administration of cisplatin-based highly emetogenic chemotherapy in patients with cancer: two randomised, active-controlled, double-blind, phase 3 trials.Lancet Oncol2015
26272768Safety and efficacy of rolapitant for prevention of chemotherapy-induced nausea and vomiting after administration of moderately emetogenic chemotherapy or anthracycline and cyclophosphamide regimens in patients with cancer: a randomised, active-controlled, double-blind, phase 3 trial.Lancet Oncol2015
24192513Major partial response to crizotinib, a dual MET/ALK inhibitor, in a squamous cell lung (SCC) carcinoma patient with de novo c-MET amplification in the absence of ALK rearrangement.Lung Cancer2014
24802392A screening pattern recognition method finds new and divergent targets for drugs and natural products.ACS Chem Biol2014
24283624Transient receptor potential ion channels in primary sensory neurons as targets for novel analgesics.Br J Pharmacol2014
22722194Large-scale prediction and testing of drug activity on side-effect targets.Nature2012
20932250Molecular structure of transient receptor potential vanilloid type 1 ion channel (TRPV1).Curr Pharm Biotechnol2011
22050465Computational methods for early predictive safety assessment from biological and chemical data.Expert Opin Drug Metab Toxicol2011
21561375IonFlux: a microfluidic patch clamp system evaluated with human Ether-à-go-go related gene channel physiology and pharmacology.Assay Drug Dev Technol2011
21742496The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors.Bioorg Med Chem Lett2011
21650221Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.J Med Chem2011
21153723Inflammatory breast cancer-comparing the effectivity of preoperative docetaxel-epirubicine protocol to conventional antracycline-containing chemotherapy to achieve clinical benefit and complete pathological response.Pathol Oncol Res2011
20932253TRPV1 function in health and disease.Curr Pharm Biotechnol2011
20179512Role of transient receptor potential and acid-sensing ion channels in peripheral inflammatory pain.Anesthesiology2010
21133679Cardiac ion channel safety profiling on the IonWorks Quattro automated patch clamp system.Assay Drug Dev Technol2010
20631060High-content micronucleus assay in genotoxicity profiling: initial-stage development and some applications in the investigative/lead-finding studies in drug discovery.Toxicol Sci2010
20154663Phenotypic screening: Fishing for neuroactive compounds.Nat Chem Biol2010
19378990Mapping adverse drug reactions in chemical space.J Med Chem2009
21426031In vitro safety pharmacology profiling: what else beyond hERG?Future Med Chem2009
19779217The accuracy of EGSnrc, Geant4 and PENELOPE Monte Carlo systems for the simulation of electron scatter in external beam radiotherapy.Phys Med Biol2009
19434832Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis.J Chem Inf Model2009
18474896Evaluation of fluorescence- and mass spectrometry-based CYP inhibition assays for use in drug discovery.J Biomol Screen2008
17492703Modeling promiscuity based on in vitro safety pharmacology profiling data.ChemMedChem2007
17916053Maximising use of in vitro ADMET tools to predict in vivo bioavailability and safety.Expert Opin Drug Metab Toxicol2007
18019783[Fixed-dose combinations in the first line of antihypertensive therapy].Acta Pharm Hung2007
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Collaborators

Department of Pharmaceutical Chemistry, University of California san francisco
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Co-authored papers 3
University of California San Francisco
Co-authored papers 2
Institut Pasteur, Universite Paris Cite, CNRS UMR9
Co-authored papers 2
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 2
University of Michigan ann arbor
Co-authored papers 2
Icahn School of Medicine at Mount Sinai
Co-authored papers 2
Novartis Institutes for BioMedical Research, Novartis Pharma AG
Co-authored papers 2
Institut Pasteur, Center for the Viral Populations and Pathogenesis
Co-authored papers 2
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 2
Novartis Pharma AG
Co-authored papers 2
Blavatnik Institute, Harvard Medical School
Co-authored papers 2
Institut Pasteur, CNRS UMR 3569
Co-authored papers 2
Novartis
Co-authored papers 2
Co-authored papers 2
Harvard Medical School
Co-authored papers 2
University of Rochester
Co-authored papers 2
University of California San Francisco
Co-authored papers 2
Quantitative Biosciences Institute (QBI), University of California San Francisco
Co-authored papers 2
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 2
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 2
Department of Preclinical Safety, Novartis Institutes for BioMedical Research
Co-authored papers 2
1 Preclinical Safety, Novartis Institutes for Biomedical Research
Co-authored papers 1
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Quantitative Biosciences Institute (QBI)
Co-authored papers 1
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 1
VCU Medical Center, Virginia Commonwealth University
Co-authored papers 1
University of North Carolina School of Medicine
Co-authored papers 1
Icahn School of Medicine at Mount Sinai
Co-authored papers 1
Icahn School of Medicine at Mount Sinai New York
Co-authored papers 1