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Author Details

Kelly K Lee
University of Washington
2002
90
38
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36561191Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infection.bioRxiv2023
37632837De novo design of monomeric helical bundles for pH-controlled membrane lysis.Protein Sci2023
38096052Combinatorial immune refocusing within the influenza hemagglutinin RBD improves cross-neutralizing antibody responses.Cell Rep2023
37121546Structural dynamics reveal subtype-specific activation and inhibition of influenza virus hemagglutinin.J Biol Chem2023
37253011Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infection.Proc Natl Acad Sci U S A2023
37166130hACE2-Induced Allosteric Activation in SARS-CoV versus SARS-CoV-2 Spike Assemblies Revealed by Structural Dynamics.ACS Infect Dis2023
37292967Combinatorial immune refocusing within the influenza hemagglutinin head elicits cross-neutralizing antibody responses.bioRxiv2023
36790205Cytoplasmic Tail Truncation Stabilizes S1-S2 Association and Enhances S Protein Incorporation into SARS-CoV-2 Pseudovirions.J Virol2023
35021101Mannose-binding lectin and complement mediate follicular localization and enhanced immunogenicity of diverse protein nanoparticle immunogens.Cell Rep2022
35383176Structure-based design of stabilized recombinant influenza neuraminidase tetramers.Nat Commun2022
35677643Structural dynamics reveal isolate-specific differences at neutralization epitopes on HIV Env.iScience2022
35970990Visualization of conformational changes and membrane remodeling leading to genome delivery by viral class-II fusion machinery.Nat Commun2022
35977542Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses.Immunity2022
35123651Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice.Cell2022
35235790Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies.Cell Rep2022
33284630Simple Platform for Automating Decoupled LC-MS Analysis of Hydrogen/Deuterium Exchange Samples.J Am Soc Mass Spectrom2021
33762730Quadrivalent influenza nanoparticle vaccines induce broad protection.Nature2021
34856127How a broadly neutralizing antibody grapples with antigenic and conformational diversity in dengue virus.Cell2021
34559844Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization.PLoS Pathog2021
34267764Stabilization of the SARS-CoV-2 Spike Receptor-Binding Domain Using Deep Mutational Scanning and Structure-Based Design.Front Immunol2021
34263727Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection.Elife2021
32276357New Biophysical Approaches Reveal the Dynamics and Mechanics of Type I Viral Fusion Machinery and Their Interplay with Membranes.Viruses2020
31721348Bridging protein structure, dynamics, and function using hydrogen/deuterium-exchange mass spectrometry.Protein Sci2020
33160446Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2.Cell2020
32759217Direct imaging of liquid domains in membranes by cryo-electron tomography.Proc Natl Acad Sci U S A2020
32868832The influence of proline isomerization on potency and stability of anti-HIV antibody 10E8.Sci Rep2020
30543159Tracking Higher Order Protein Structure by Hydrogen-Deuterium Exchange Mass Spectrometry.Protein Pept Lett2019
31405964Prebiotic amino acids bind to and stabilize prebiotic fatty acid membranes.Proc Natl Acad Sci U S A2019
31019050Deep Mutational Scan of the Highly Conserved Influenza A Virus M1 Matrix Protein Reveals Substantial Intrinsic Mutational Tolerance.J Virol2019
31097662De novo design of tunable, pH-driven conformational changes.Science2019
30849373Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus.Cell2019
29263254Dissection of Epitope-Specific Mechanisms of Neutralization of Influenza Virus by Intact IgG and Fab Fragments.J Virol2018
30151578Influenza Virus-Liposome Fusion Studies Using Fluorescence Dequenching and Cryo-electron Tomography.Methods Mol Biol2018
30096307Single-Molecule Analysis of a Viral Fusion Protein Illuminates a Fusion-Active Intermediate State.Cell2018
29669274Superinfection Drives HIV Neutralizing Antibody Responses from Several B Cell Lineages that Contribute to a Polyclonal Repertoire.Cell Rep2018
29739835Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses.J Exp Med2018
29268688Probing Structural Variation and Dynamics in the HIV-1 Env Fusion Glycoprotein.Curr HIV Res2018
28604661Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site.Nat Biotechnol2017
28814519Extracellular Matrix Proteins Mediate HIV-1 gp120 Interactions with α<sub>4</sub>β<sub>7</sub>.J Virol2017
28834745Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization.Cell Rep2017
26810432Tuning a High Transmission Ion Guide to Prevent Gas-Phase Proton Exchange During H/D Exchange MS Analysis.J Am Soc Mass Spectrom2016
27627672Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C.PLoS Pathog2016
27362353Dissecting Virus Infectious Cycles by Cryo-Electron Microscopy.PLoS Pathog2016
27478931Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV.Nat Struct Mol Biol2016
27477385Somatic Hypermutation-Induced Changes in the Structure and Dynamics of HIV-1 Broadly Neutralizing Antibodies.Structure2016
27226364Visualization and Sequencing of Membrane Remodeling Leading to Influenza Virus Fusion.J Virol2016
27345369HIV-1 Neutralizing Antibodies with Limited Hypermutation from an Infant.Cell2016
27489265Changes in Structure and Antigenicity of HIV-1 Env Trimers Resulting from Removal of a Conserved CD4 Binding Site-Proximal Glycan.J Virol2016
27512064Epitope-Independent Purification of Native-Like Envelope Trimers from Diverse HIV-1 Isolates.J Virol2016
26689967Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design.Nat Struct Mol Biol2016
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Collaborators

Miklos Guttman
University of Washington
Co-authored papers 37
Neil P King
Co-authored papers 9
Ian A Wilson
The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology
Co-authored papers 8
John P Moore
Co-authored papers 8
Celia C LaBranche
Co-authored papers 6
John R Mascola
Co-authored papers 6
David C Montefiori
Co-authored papers 6
Lauren Carter
Co-authored papers 5
David Veesler
Co-authored papers 5
John C Kraft
Co-authored papers 5
David Baker
University of Washington
Co-authored papers 5
Michael Murphy
Co-authored papers 5
Yongping Yang
Co-authored papers 4
Cinque Soto
Co-authored papers 4
Marie Pancera
Co-authored papers 4
Peter D Kwong
Co-authored papers 4
Thomas J Ketas
Co-authored papers 4
Baoshan Zhang
Co-authored papers 4
Michael G Joyce
Co-authored papers 4
Hiro Tsuruta
Stanford University
Co-authored papers 3
Gwo-Yu Chuang
Co-authored papers 3
Brooke Fiala
Co-authored papers 3
James B Munro
University of Massachusetts Chan Medical School
Co-authored papers 3
Nicole A Doria-Rose
Co-authored papers 3
Aliaksandr Druz
Co-authored papers 3
Tongqing Zhou
Co-authored papers 3
Ivelin S Georgiev
Co-authored papers 3
Caitlin I Stoddard
Fred Hutchinson Cancer Center.
Co-authored papers 2
Lawrence Shapiro
Zuckerman Mind Brain Behaviour Institute
Co-authored papers 2
Mary Jane Navarro
Co-authored papers 2
Release 1.2