|
| 36793435 | Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor. | ACS Med Chem Lett | 2023 |
| 37695851 | Metabolic Lipids in Melanoma Enable Rapid Determination of Actionable BRAF-V600E Mutation with Picosecond Infrared Laser Mass Spectrometry in 10 s. | Anal Chem | 2023 |
| 37354357 | An effective kinase inhibition strategy for metastatic recurrent childhood medulloblastoma. | J Neurooncol | 2023 |
| 37369212 | Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity. | Cell Chem Biol | 2023 |
| 34958585 | Correction to "Structure-Activity Relationship of USP5 Inhibitors". | J Med Chem | 2022 |
| 36395434 | Picosecond Infrared Laser Mass Spectrometry Identifies a Metabolite Array for 10 s Diagnosis of Select Skin Cancer Types: A Proof-of-Concept Feasibility Study. | Anal Chem | 2022 |
| 36084291 | Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes. | ACS Chem Biol | 2022 |
| 34963044 | Correction to "Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma". | J Med Chem | 2022 |
| 33476303 | A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity. | JCI Insight | 2021 |
| 33651938 | Mass Spectrometry Imaging Reveals a Gradient of Cancer-like Metabolic States in the Vicinity of Cancer Not Seen in Morphometric Margins from Microscopy. | Anal Chem | 2021 |
| 33579912 | PRMT5 inhibition disrupts splicing and stemness in glioblastoma. | Nat Commun | 2021 |
| 34648286 | Structure-Activity Relationship of USP5 Inhibitors. | J Med Chem | 2021 |
| 34662547 | Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells. | J Mol Biol | 2021 |
| 34291633 | Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma. | J Med Chem | 2021 |
| 34055235 | Leveraging Open Science Drug Development for PET: Preliminary Neuroimaging of <sup>11</sup>C-Labeled ALK2 Inhibitors. | ACS Med Chem Lett | 2021 |
| 32369358 | Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma. | J Med Chem | 2020 |
| 32094923 | A drug discovery platform to identify compounds that inhibit EGFR triple mutants. | Nat Chem Biol | 2020 |
| 32778845 | Functional characterization of a PROTAC directed against BRAF mutant V600E. | Nat Chem Biol | 2020 |
| 32409666 | Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. | Nat Commun | 2020 |
| 32457299 | Author Correction: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. | Nat Commun | 2020 |
| 32226941 | EGFR blockade in GBM brain tumor stem cells synergizes with JAK2/STAT3 pathway inhibition to abrogate compensatory mechanisms in vitro and in vivo. | Neurooncol Adv | 2020 |
| 31173706 | The Mitochondrial Transacylase, Tafazzin, Regulates AML Stemness by Modulating Intracellular Levels of Phospholipids. | Cell Stem Cell | 2019 |
| 30840432 | Colloidal Drug Aggregate Stability in High Serum Conditions and Pharmacokinetic Consequence. | ACS Chem Biol | 2019 |
| 30890619 | Picosecond Infrared Laser Desorption Mass Spectrometry Identifies Medulloblastoma Subgroups on Intrasurgical Timescales. | Cancer Res | 2019 |
| 30300580 | MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis. | Cancer Cell | 2018 |
| 29253028 | The JAK2/STAT3 inhibitor pacritinib effectively inhibits patient-derived GBM brain tumor initiating cells in vitro and when used in combination with temozolomide increases survival in an orthotopic xenograft model. | PLoS One | 2017 |
| 28161682 | Preclinical evaluation of taxane-binding peptide-modified polymeric micelles loaded with docetaxel in an orthotopic breast cancer mouse model. | Biomaterials | 2017 |
| 28989676 | Rapid determination of medulloblastoma subgroup affiliation with mass spectrometry using a handheld picosecond infrared laser desorption probe. | Chem Sci | 2017 |
| 27076069 | Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy. | Cell Metab | 2016 |
| 27618721 | Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay. | Stem Cell Reports | 2016 |
| 27587383 | Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells. | Haematologica | 2016 |
| 27449082 | Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells. | Oncotarget | 2016 |
| 26735719 | Genotoxic and carcinogenic products arising from reductive transformations of the azo dye, Disperse Yellow 7. | Chemosphere | 2016 |
| 27006494 | Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma. | Clin Cancer Res | 2016 |
| 25832785 | Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells. | Apoptosis | 2015 |
| 26158521 | FV-162 is a novel, orally bioavailable, irreversible proteasome inhibitor with improved pharmacokinetics displaying preclinical efficacy with continuous daily dosing. | Cell Death Dis | 2015 |
| 26058080 | Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia. | Cancer Cell | 2015 |
| 24487029 | shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer. | Cancer Res | 2014 |
| 25136132 | (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. | Proc Natl Acad Sci U S A | 2014 |
| 23818141 | α-Boryl isocyanides enable facile preparation of bioactive boropeptides. | Angew Chem Int Ed Engl | 2013 |
| 24900612 | Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma. | ACS Med Chem Lett | 2013 |
| 22182751 | Amphiphilic micelles of poly(2-methyl-2-carboxytrimethylene carbonate-co-D,L-lactide)-graft-poly(ethylene glycol) for anti-cancer drug delivery to solid tumours. | Biomaterials | 2012 |
| 23250418 | Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. | Nat Commun | 2012 |
| 22967490 | A docetaxel-carboxymethylcellulose nanoparticle outperforms the approved taxane nanoformulation, Abraxane, in mouse tumor models with significant control of metastases. | J Control Release | 2012 |
| 22795084 | An allosteric inhibitor of protein arginine methyltransferase 3. | Structure | 2012 |
| 22619253 | L-745,870 reduces L-DOPA-induced dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease. | J Pharmacol Exp Ther | 2012 |
| 22009536 | Wnt inhibitor screen reveals iron dependence of β-catenin signaling in cancers. | Cancer Res | 2011 |
| 22014571 | Virus-tumor interactome screen reveals ER stress response can reprogram resistant cancers for oncolytic virus-triggered caspase-2 cell death. | Cancer Cell | 2011 |
| 20580569 | Investigation of the noncovalent interactions between anti-amyloid agents and amyloid beta peptides by ESI-MS. | J Am Soc Mass Spectrom | 2010 |
| 16675063 | Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis. | Neurobiol Aging | 2007 |