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Author Details

Ludmil B Alexandrov
Moores Cancer Center, university of california san diego
2007
146
63
PMIDPaper TitleJournal TitlePublished Year
37971722Nivolumab for Patients With High-Risk Oral Leukoplakia: A Nonrandomized Controlled Trial.JAMA Oncol2024
37971722Nivolumab for Patients With High-Risk Oral Leukoplakia: A Nonrandomized Controlled Trial.JAMA Oncol2024
36928603Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneity.Nat Genet2023
37605126Visualizing and exploring patterns of large mutational events with SigProfilerMatrixGenerator.BMC Genomics2023
37735199APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer.Nat Genet2023
38096571Assigning mutational signatures to individual samples and individual somatic mutations with SigProfilerAssignment.Bioinformatics2023
36778452Visualizing and exploring patterns of large mutational events with SigProfilerMatrixGenerator.bioRxiv2023
36650165DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer.Nat Commun2023
36756361Unraveling the impact of a germline heterozygous <i>POLD1</i> frameshift variant in serrated polyposis syndrome.Front Mol Biosci2023
36702933Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers.Nat Cancer2023
36697836Author Correction: The repertoire of mutational signatures in human cancer.Nature2023
37316668Mitotic tethering enables inheritance of shattered micronuclear chromosomes.Nature2023
36865271Arsenic is a potent co-mutagen of ultraviolet light.bioRxiv2023
37173324Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response.Nat Commun2023
37046091Chromosomal fragile site breakage by EBV-encoded EBNA1 at clustered repeats.Nature2023
37046089Extrachromosomal DNA in the cancerous transformation of Barrett's oesophagus.Nature2023
36928603Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneity.Nat Genet2023
36604421Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis.Nat Commun2023
36918603Author Correction: DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer.Nat Commun2023
37540596Topography of mutational signatures in human cancer.Cell Rep2023
37502962Assigning mutational signatures to individual samples and individual somatic mutations with SigProfilerAssignment.bioRxiv2023
36525930Ovarian and uterine carcinosarcomas are sensitive in vitro and in vivo to elimusertib, a novel ataxia-telangiectasia and Rad3-related (ATR) kinase inhibitor.Gynecol Oncol2023
37502962Assigning mutational signatures to individual samples and individual somatic mutations with SigProfilerAssignment.bioRxiv2023
37735199APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer.Nat Genet2023
37540596Topography of mutational signatures in human cancer.Cell Rep2023
38096571Assigning mutational signatures to individual samples and individual somatic mutations with SigProfilerAssignment.Bioinformatics2023
37605126Visualizing and exploring patterns of large mutational events with SigProfilerMatrixGenerator.BMC Genomics2023
37316668Mitotic tethering enables inheritance of shattered micronuclear chromosomes.Nature2023
37046091Chromosomal fragile site breakage by EBV-encoded EBNA1 at clustered repeats.Nature2023
37046089Extrachromosomal DNA in the cancerous transformation of Barrett's oesophagus.Nature2023
37173324Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response.Nat Commun2023
36697836Author Correction: The repertoire of mutational signatures in human cancer.Nature2023
36650165DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer.Nat Commun2023
36918603Author Correction: DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer.Nat Commun2023
36778452Visualizing and exploring patterns of large mutational events with SigProfilerMatrixGenerator.bioRxiv2023
36604421Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis.Nat Commun2023
36865271Arsenic is a potent co-mutagen of ultraviolet light.bioRxiv2023
36702933Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers.Nat Cancer2023
36756361Unraveling the impact of a germline heterozygous <i>POLD1</i> frameshift variant in serrated polyposis syndrome.Front Mol Biosci2023
36525930Ovarian and uterine carcinosarcomas are sensitive in vitro and in vivo to elimusertib, a novel ataxia-telangiectasia and Rad3-related (ATR) kinase inhibitor.Gynecol Oncol2023
35140368Unwinding the mutational signatures of a DNA topoisomerase enzyme.Nature2022
35595234Examining clustered somatic mutations with SigProfilerClusters.Bioinformatics2022
36042521A genetic model for central chondrosarcoma evolution correlates with patient outcome.Genome Med2022
35705804Signatures of copy number alterations in human cancer.Nature2022
35641325Synergistic activity of neratinib in combination with olaparib in uterine serous carcinoma overexpressing HER2/neu.Gynecol Oncol2022
35420163An overview of mutational and copy number signatures in human cancer.J Pathol2022
36134663AI-assisted discovery of an ethnicity-influenced driver of cell transformation in esophageal and gastroesophageal junction adenocarcinomas.JCI Insight2022
35859169Mechanisms of APOBEC3 mutagenesis in human cancer cells.Nature2022
36395141Somatic 9p24.1 alterations in HPV<sup>-</sup> head and neck squamous cancer dictate immune microenvironment and anti-PD-1 checkpoint inhibitor activity.Proc Natl Acad Sci U S A2022
36388765Uncovering novel mutational signatures by <i>de novo</i> extraction with SigProfilerExtractor.Cell Genom2022
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Collaborators

Michael R Stratton
Wellcome Sanger Institute
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Peter J Campbell
Wellcome Sanger Institute
Co-authored papers 39
David C Wedge
Manchester Cancer Research Centre, University of Manchester
Co-authored papers 32
Serena Nik-Zainal
Early Cancer Institute, University of Cambridge
Co-authored papers 24
Inigo Martincorena
Wellcome Sanger Institute
Co-authored papers 21
Peter Van Loo
The Francis Crick Institute
Co-authored papers 20
Adam Butler
Wellcome Sanger Institute
Co-authored papers 18
Keiran Raine
Wellcome Sanger Institute
Co-authored papers 16
Jon Teague
Wellcome Sanger Institute
Co-authored papers 15
Manasa Ramakrishna
Co-authored papers 14
Phillip A Futreal
The University of Texas MD Anderson Cancer Center
Co-authored papers 14
Ultan McDermott
Wellcome Sanger Institute
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Andrew Menzies
Wellcome Sanger Institute
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Andrea L Richardson
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David Jones
Wellcome Sanger Institute
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Gunes Gundem
Memorial Sloan Kettering Cancer Center
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Patrick S Tarpey
Wellcome Trust Sanger Institute
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Laura Mudie
Wellcome Trust Sanger Institute
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Moritz Gerstung
German Cancer Research Centre DKFZ
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Stuart McLaren
Wellcome Trust Sanger Institute
Co-authored papers 10
Sarah O'Meara
Clinical Research Facility, Mercy University Hospital
Co-authored papers 9
Lucy A Stebbings
Wellcome Trust Sanger Institute
Co-authored papers 9
Anne-Lise B??rresen-Dale
Institute for Cancer Research, Oslo University Hospital
Co-authored papers 9
Susanna L Cooke
Institute of Cancer Sciences, University of Glasgow
Co-authored papers 9
Mark Maddison
Wellcome Sanger Institute
Co-authored papers 8
John W M Martens
Erasmus Medical Center (MC) Cancer Institute
Co-authored papers 8
Scott M Lippman
Moores Cancer Center, university of california san diego
Co-authored papers 8
Adrienne M Flanagan
University College London, UCL Cancer Institute
Co-authored papers 8
David E Neal
University of Oxford, John Radcliffe Hospital
Co-authored papers 7
Jonathan Hinton
Inivata Ltd
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