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Author Details

Jason E Gestwicki
Institute for Neurodegenerative Diseases, University of California San Francisco
2000
218
68
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36264168N-myc-Mediated Translation Control Is a Therapeutic Vulnerability in Medulloblastoma.Cancer Res2023
37791314An Unbiased Screen Identified the Hsp70-BAG3 Complex as a Regulator of Myosin-Binding Protein C3.JACC Basic Transl Sci2023
37943662Protocol for performing and optimizing differential scanning fluorimetry experiments.STAR Protoc2023
37781598<i>De novo</i> designed Hsp70 activator dissolves intracellular condensates.bioRxiv2023
37330289The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT).J Mol Biol2023
37293102Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly.bioRxiv2023
37091547Mitoribosome sensitivity to HSP70 inhibition uncovers metabolic liabilities of castration-resistant prostate cancer.PNAS Nexus2023
36753572Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States.J Am Chem Soc2023
36747624Conformationally responsive dyes enable protein-adaptive differential scanning fluorimetry.bioRxiv2023
36773708Allosteric inhibition of HSP70 in collaboration with STUB1 augments enzalutamide efficacy in antiandrogen resistant prostate tumor and patient-derived models.Pharmacol Res2023
35108506Selective vulnerabilities in the proteostasis network of castration-resistant prostate cancer.Cell Chem Biol2022
35670950Multivalent protein-protein interactions are pivotal regulators of eukaryotic Hsp70 complexes.Cell Stress Chaperones2022
35830852A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities.Cell Chem Biol2022
35853457Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma.Cell Chem Biol2022
35594848Multi-protein complexes as drug targets.Cell Chem Biol2022
35654899Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate.Nat Commun2022
35413950Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.Nat Commun2022
35162987Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells.Int J Mol Sci2022
35148989Two distinct classes of cochaperones compete for the EEVD motif in heat shock protein 70 to tune its chaperone activities.J Biol Chem2022
35264557The YΦ motif defines the structure-activity relationships of human 20S proteasome activators.Nat Commun2022
33236291Exported plasmodial J domain protein, PFE0055c, and PfHsp70-x form a specific co-chaperone-chaperone partnership.Cell Stress Chaperones2021
33854069Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice.Nat Commun2021
33547632Functional genomics screen identifies proteostasis targets that modulate prion protein (PrP) stability.Cell Stress Chaperones2021
33853786Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.Sci Adv2021
33904310Retraction of "Enantioselective Organocatalytic Hantzsch Synthesis of Polyhydroquinolines".Org Lett2021
33839251Inhibitors of heat shock protein 70 (Hsp70) with enhanced metabolic stability reduce tau levels.Bioorg Med Chem Lett2021
33549906Chemical validation of a druggable site on Hsp27/HSPB1 using in silico solvent mapping and biophysical methods.Bioorg Med Chem2021
34380015The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state.Mol Cell2021
34606726Inhibitor Combinations Reveal Wiring of the Proteostasis Network in Prostate Cancer Cells.J Med Chem2021
34624315The interactions of molecular chaperones with client proteins: why are they so weak?J Biol Chem2021
34019840Adhesion-mediated mechanosignaling forces mitohormesis.Cell Metab2021
31714737End-Binding E3 Ubiquitin Ligases Enable Protease Signaling.ACS Chem Biol2021
31509197Individualized management of genetic diversity in Niemann-Pick C1 through modulation of the Hsp70 chaperone system.Hum Mol Genet2020
34123282Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells.Chem Sci2020
31906970Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy.Mol Neurodegener2020
32022992Pharmacologic dissection of the overlapping impact of heat shock protein family members on platelet function.J Thromb Haemost2020
32017918Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone.Cell Chem Biol2020
31952963Neutral analogs of the heat shock protein 70 (Hsp70) inhibitor, JG-98.Bioorg Med Chem Lett2020
32918866Luminescence complementation assay for measurement of binding to protein C-termini in live cells.Anal Biochem2020
32944137A Phosphoramidate Strategy Enables Membrane Permeability of a Non-nucleotide Inhibitor of the Prolyl Isomerase Pin1.ACS Med Chem Lett2020
32458889Differential scanning fluorimetry (DSF) screen to identify inhibitors of Hsp60 protein-protein interactions.Org Biomol Chem2020
32427588Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy.J Clin Invest2020
32291414Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability.Oncogene2020
32255605A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography.ACS Chem Biol2020
32156782Mortalin (HSPA9) facilitates <i>BRAF</i>-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability.Sci Signal2020
30507174Designing de Novo Small Molecules That Control Heat Shock Protein 70 (Hsp70) and Heat Shock Organizing Protein (HOP) within the Chaperone Protein-Folding Machinery.J Med Chem2019
30213856Inhibitors and chemical probes for molecular chaperone networks.J Biol Chem2019
30166590The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20.Oncogene2019
31320752Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases.Nat Chem Biol2019
31578281Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation.J Biol Chem2019
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Collaborators

Hao Shao
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 35
Laura L Kiessling
Massachusetts Institute of Technology
Co-authored papers 16
Sue-Ann Mok
University of Alberta
Co-authored papers 12
Daniel R Southworth
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Co-authored papers 11
Heather A Carlson
University of Michigan ann arbor
Co-authored papers 10
Eric Tse
School of Clinical Medicine, University of Hong Kong
Co-authored papers 7
Peter Man-Un Ung
Co-authored papers 7
Ana Maria Cuervo
Albert Einstein College of Medicine
Co-authored papers 6
Li Gan
Helen and Robert Appel Alzheimer's Disease Research Institute
Co-authored papers 5
Chao Wang
Gladstone Institutes
Co-authored papers 4
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Whitehead Institute for Biomedical Research
Co-authored papers 4
Martin Kampmann
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Co-authored papers 4
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Harvard Medical School
Co-authored papers 4
Peter Dongmin Sohn
Gladstone Institutes
Co-authored papers 4
Kwadwo Opoku-Nsiah
Stanford University
Co-authored papers 3
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Co-authored papers 3
Susmita Kaushik
Albert Einstein College of Medicine
Co-authored papers 3
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Gladstone Institutes
Co-authored papers 3
Judith Frydman
Stanford University
Co-authored papers 3
Laura Santambrogio
Weill Cornell School of Medicine
Co-authored papers 3
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 3
Edwin J Weeber
University of South Florida
Co-authored papers 3
Thomas J Begley
University at Albany
Co-authored papers 2
David Sulzer
New York State Psychiatric Institute, Research Foundation for Mental Hygiene
Co-authored papers 2
David M Sabatini
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
Co-authored papers 2
J. Wade Harper
Harvard Medical School
Co-authored papers 2
Nikolai V Gorbunov
Armed Forces Radiobiology Research Institute
Co-authored papers 2
Juan Fueyo
The University of Texas M.D. Anderson Cancer Center
Co-authored papers 2
Max S Wicha
Co-authored papers 2
Lawrence H Boise
Winship Cancer Institute, Emory University
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