|
| 34902734 | Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (Ï¿<sub>1</sub>) receptor ligands with potent anti-amnesic effect. | Eur J Med Chem | 2022 |
| 34586588 | Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models. | Cell Oncol (Dordr) | 2021 |
| 33052254 | Why PB28 Could Be a Covid 2019 Game Changer? | ACS Med Chem Lett | 2020 |
| 31973006 | NO1, a New Sigma 2 Receptor/TMEM97 Fluorescent Ligand, Downregulates SOCE and Promotes Apoptosis in the Triple Negative Breast Cancer Cell Lines. | Cancers (Basel) | 2020 |
| 33060197 | Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. | Science | 2020 |
| 33364961 | PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti-SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships. | Front Pharmacol | 2020 |
| 31633399 | High-affinity sigma-1 (Ï¿<sub>1</sub>) receptor ligands based on the Ï¿<sub>1</sub> antagonist PB212. | Future Med Chem | 2019 |
| 31265310 | Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells. | Mol Pharm | 2019 |
| 29287249 | Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ͽ<sub>2</sub>) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors. | Eur J Med Chem | 2018 |
| 35542423 | An innovative small molecule for promoting neuroreparative strategies. | RSC Adv | 2018 |
| 29966437 | Sigma-2 receptor: past, present and perspectives on multiple therapeutic exploitations. | Future Med Chem | 2018 |
| 29531859 | Synthesis, radiolabelling, and evaluation of [<sup>11</sup>C]PB212 as a radioligand for imaging sigma-1 receptors using PET. | Am J Nucl Med Mol Imaging | 2018 |
| 28007569 | Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1. | Pharmacol Res | 2017 |
| 28364693 | The Ï¿<sub>1</sub> receptor agonist (+)-pentazocine increases store-operated Ca<sup>2+</sup> entry in MCF7Ï¿<sub>1</sub> and SK-N-SH cell lines. | Pharmacol Rep | 2017 |
| 28086830 | Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer. | BMC Cancer | 2017 |
| 28120522 | Sigma 2 receptor expression levels in blood and bladder from healthy and bladder cancer cattle. | Vet Comp Oncol | 2017 |
| 26717207 | Development of sigma-1 (Ï¿1) receptor fluorescent ligands as versatile tools to study Ï¿1 receptors. | Eur J Med Chem | 2016 |
| 27514711 | Design and Synthesis of New Selective P-gp Substrates and Inhibitors. | Curr Pharm Des | 2016 |
| 26750618 | Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands. | Arch Pharm (Weinheim) | 2016 |
| 25462269 | From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump. | Eur J Med Chem | 2015 |
| 25843410 | Elements in support of the 'non-identity' of the PGRMC1 protein with the Ï¿2 receptor. | Eur J Pharmacol | 2015 |
| 25666889 | Live imaging reveals a new role for the sigma-1 (Ï¿1) receptor in allowing microglia to leave brain injuries. | Neurosci Lett | 2015 |
| 25637276 | Synthesis and pharmacological evaluation of ¹¹C-labeled piperazine derivative as a PET probe for sigma-2 receptor imaging. | Nucl Med Biol | 2015 |
| 25757101 | Novel and Selective Fluorescent Ï¿2 -Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study Ï¿2 Receptors in Living Cells. | Chembiochem | 2015 |
| 25462276 | Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity from Ï¿2 receptor affinity in mixed P-gp/Ï¿2 receptor agents. | Eur J Med Chem | 2015 |
| 24174335 | PET radiotracers for imaging P-glycoprotein: the challenge for early diagnosis in AD. | ChemMedChem | 2014 |
| 25379609 | SAR studies on tetrahydroisoquinoline derivatives: the role of flexibility and bioisosterism to raise potency and selectivity toward P-glycoprotein. | J Med Chem | 2014 |
| 25093931 | Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding. | J Med Chem | 2014 |
| 24732791 | Synthesis, radiolabeling and in vivo evaluation of [(11)C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT(7) receptor. | Eur J Med Chem | 2014 |
| 24911087 | The effects of new sigma (Ï¿) receptor ligands, PB190 and PB212, in the models predictive of antidepressant activity. | Pharmacol Rep | 2014 |
| 24508140 | Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HTâ¿¿ receptor. | Bioorg Med Chem | 2014 |
| 24622785 | Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. | Rev Neurosci | 2014 |
| 24591318 | Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. | Chem Biodivers | 2014 |
| 24697311 | Novel derivatives of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with improved fluorescent and Ï¿ receptors binding properties. | J Med Chem | 2014 |
| 23347803 | Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters. | Bioorg Med Chem | 2013 |
| 24106081 | Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: hints for collateral sensitivity. | ChemMedChem | 2013 |
| 24100077 | Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties. | Bioorg Med Chem Lett | 2013 |
| 24161678 | Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of Ï¿â¿¿ receptors. | Eur J Med Chem | 2013 |
| 23726026 | Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments. | Bioorg Med Chem Lett | 2013 |
| 23415062 | Investigation of Ï¿ receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines. | Bioorg Med Chem | 2013 |
| 23571499 | Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters. | Exp Brain Res | 2013 |
| 23234641 | Comparative evaluation of two dye probes in the rat everted gut sac model for unambiguous classification of P-gp substrate and inhibitor. | J Pharmacol Toxicol Methods | 2013 |
| 23374872 | Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp. | Bioorg Med Chem Lett | 2013 |
| 22112208 | Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. | J Med Chem | 2012 |
| 22788968 | The therapeutic potential of 5-HT1A receptors: a patent review. | Expert Opin Ther Pat | 2012 |
| 22738316 | Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo. | J Med Chem | 2012 |
| 22890883 | 2-Aminopyridine derivatives as potential Ï¿(2) receptor antagonists. | ChemMedChem | 2012 |
| 22873661 | Activatable fluorescent probes: a new concept in optical molecular imaging. | Curr Med Chem | 2012 |
| 22465185 | The sigma-1 receptor antagonist PB212 reduces the Ca²âº-release through the inositol (1, 4, 5)-trisphosphate receptor in SK-N-SH cells. | Eur J Pharmacol | 2012 |
| 22551149 | Lysosomal membrane permeabilization is an early event in Sigma-2 receptor ligand mediated cell death in pancreatic cancer. | J Exp Clin Cancer Res | 2012 |