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Author Details

Susan P Lees-Miller
University of Calgary, 0 Hospital Drive NW
1989
180
76
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37668363Prevalence and Prognostic Significance of PIK3CA Mutation and CNV Status and Phosphorylated AKT Expression in Patients With Cervical Cancer Treated With Primary Surgery.Int J Gynecol Pathol2024
37256947Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ.Sci Adv2023
37851921High-Efficiency Enrichment by Saturating Nanoliters of Protein Affinity Media.Anal Chem2023
37787023How to fix DNA breaks: new insights into the mechanism of non-homologous end joining.Biochem Soc Trans2023
35290641Purification of DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs) from HeLa Cells.Methods Mol Biol2022
36532708A genetic roadmap to the response to genotoxic agents in human cells.Fac Rev2022
36243983KRCC1, a modulator of the DNA damage response.Nucleic Acids Res2022
32966823Visualizing functional dynamicity in the DNA-dependent protein kinase holoenzyme DNA-PK complex by integrating SAXS with cryo-EM.Prog Biophys Mol Biol2021
33854234Structural basis of long-range to short-range synaptic transition in NHEJ.Nature2021
34970273Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy.Front Immunol2021
34723130Structural insights into the role of DNA-PK as a master regulator in NHEJ.Genome Instab Dis2021
34321241Long Noncoding RNA NIHCOLE Promotes Ligation Efficiency of DNA Double-Strand Breaks in Hepatocellular Carcinoma.Cancer Res2021
34337539Decreased ATM Protein Expression Is Substantiated with PTEN Loss in Defining Aggressive Phenotype of Prostate Cancer Associated with Lethal Disease.Eur Urol Open Sci2021
33337499Mechanism of efficient double-strand break repair by a long non-coding RNA.Nucleic Acids Res2021
33412091The active DNA-PK holoenzyme occupies a tensed state in a staggered synaptic complex.Structure2021
33035590Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease.Prog Biophys Mol Biol2021
32303715Correction: Combined poly-ADP ribose polymerase and ataxia-telangiectasia mutated/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells.Br J Cancer2020
31934630DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP.Sci Adv2020
33045735Mechanism of efficient double-strand break repair by a long non-coding RNA.Nucleic Acids Res2020
32653099PIK3CA mutation and CNV status and post-chemoradiotherapy survival in patients with cervical cancer.Gynecol Oncol2020
32284347Nocodazole-Induced Expression and Phosphorylation of Anillin and Other Mitotic Proteins Are Decreased in DNA-Dependent Protein Kinase Catalytic Subunit-Deficient Cells and Rescued by Inhibition of the Anaphase-Promoting Complex/Cyclosome with proTAME but Not Apcin.Mol Cell Biol2020
32183301ATM-Deficient Cancers Provide New Opportunities for Precision Oncology.Cancers (Basel)2020
31390569Nej1 Interacts with Mre11 to Regulate Tethering and Dna2 Binding at DNA Double-Strand Breaks.Cell Rep2019
31570166SSEThread: Integrative threading of the DNA-PKcs sequence based on data from chemical cross-linking and hydrogen deuterium exchange.Prog Biophys Mol Biol2019
31481733Combined poly-ADP ribose polymerase and ataxia-telangiectasia mutated/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells.Br J Cancer2019
29786079Dissection of DNA double-strand-break repair using novel single-molecule forceps.Nat Struct Mol Biol2018
28059093Expression of PD-L1 and presence of CD8-positive T cells in pre-treatment specimens of locally advanced cervical cancer.Mod Pathol2017
28131528Expression of DNA damage response proteins in cervical cancer patients treated with radical chemoradiotherapy.Gynecol Oncol2017
28453785Structural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex.Nucleic Acids Res2017
28188792Recruitment of PP1 to the centrosomal scaffold protein CEP192.Biochem Biophys Res Commun2017
28126304Significance of Co-expression of Epidermal Growth Factor Receptor and Ki67 on Clinical Outcome in Patients With Anal Cancer Treated With Chemoradiotherapy: An Analysis of NRG Oncology RTOG 9811.Int J Radiat Oncol Biol Phys2017
28154854Nanospray HX-MS configuration for structural interrogation of large protein systems.Analyst2017
28182994ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib.Transl Oncol2017
28418844Loss of tumour-specific ATM protein expression is an independent prognostic factor in early resected NSCLC.Oncotarget2017
29594208Anemia, leukocytosis and thrombocytosis as prognostic factors in patients with cervical cancer treated with radical chemoradiotherapy: A retrospective cohort study.Clin Transl Radiat Oncol2017
28668129What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses.Methods Enzymol2017
28641126DNA requirements for interaction of the C-terminal region of Ku80 with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).DNA Repair (Amst)2017
28679532The non-homologous end-joining factor Nej1 inhibits resection mediated by Dna2-Sgs1 nuclease-helicase at DNA double strand breaks.J Biol Chem2017
27489350Phosphatidyl inositol-3 kinase (PIK3CA) E545K mutation confers cisplatin resistance and a migratory phenotype in cervical cancer cells.Oncotarget2016
27875301An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex.J Biol Chem2016
27741524Low Ki67/high ATM protein expression in malignant tumors predicts favorable prognosis in a retrospective study of early stage hormone receptor positive breast cancer.Oncotarget2016
27273637Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer.Nat Struct Mol Biol2016
27303920Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions.Oncotarget2016
25550082The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis.Prog Biophys Mol Biol2015
26316455Fumarate in DNA repair.Nat Cell Biol2015
25942368Role of the yeast DNA repair protein Nej1 in end processing during the repair of DNA double strand breaks by non-homologous end joining.DNA Repair (Amst)2015
25986610Phosphorylation of SAF-A/hnRNP-U Serine 59 by Polo-Like Kinase 1 Is Required for Mitosis.Mol Cell Biol2015
25935535Low ATM protein expression in malignant tumor as well as cancer-associated stroma are independent prognostic factors in a retrospective study of early-stage hormone-negative breast cancer.Breast Cancer Res2015
24369855The C-terminus of Nej1 is critical for nuclear localization and non-homologous end-joining.DNA Repair (Amst)2014
25165869DNA double strand break repair in mitosis is suppressed by phosphorylation of XRCC4.PLoS Genet2014
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Collaborators

John A Tainer
The University of Texas MD Anderson Cancer Center
Co-authored papers 17
Michal Hammel
Lawrence Berkeley National Laboratory
Co-authored papers 12
Shujuan Fang
Charbonneau Cancer Institute, University of Calgary
Co-authored papers 11
Elizabeth N Kornaga
Tom Baker Cancer Centre
Co-authored papers 9
Linda Lee
Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary
Co-authored papers 8
David C Schriemer
University of Calgary, 0 Hospital Drive NW
Co-authored papers 8
Ettore Appella
Co-authored papers 5
Stephen P Jackson
Mission Therapeutics Ltd. Glenn Berge Building
Co-authored papers 4
Tom L Blundell
Heartand Lung Research Institute, University of Cambridge
Co-authored papers 4
Martin K??bel
University of Calgary
Co-authored papers 3
Pinaki Bose
Cumming School of Medicine, University of Calgary
Co-authored papers 3
Morgan Hepburn
University of Calgary
Co-authored papers 3
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 2
Dario R Alessi
University of Dundee
Co-authored papers 2
Sze Fai Yip
Tuen Mun Hospital
Co-authored papers 2
Greg L Hura
Lawrence Berkeley National Laboratory, University of California Santa Cruz
Co-authored papers 2
Daniel J Saltzberg
University of California san francisco
Co-authored papers 2
Michael M Soniat
The University of Texas at Austin, USA Center for Systems and Synthetic Biology
Co-authored papers 1
Lewis C Cantley
Co-authored papers 1
Natalie C J Strynadka
The University of British Columbia
Co-authored papers 1
Haico van Attikum
Leiden University Medical Center
Co-authored papers 1
Thomas Helleday
The University of Sheffield
Co-authored papers 1
Roseline Godbout
University of Alberta
Co-authored papers 1
Christina S Kong
Stanford University School of Medicine
Co-authored papers 1
Soumya G Remesh
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 1
Sunita Ghosh
Cross Cancer Institute
Co-authored papers 1
Scott R Burrows
Co-authored papers 1
Chirayu Chokshi
McMaster University
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Karine Dubrana
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Release 1.2