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Author Details

Donald D Lorimer
Seattle Structural Genomics Center for Infectious Disease (SSGCID)
1986
61
22
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37117205Structural characterisation of hemagglutinin from seven Influenza A H1N1 strains reveal diversity in the C05 antibody recognition site.Sci Rep2023
37728609Characterization of a family I inorganic pyrophosphatase from Legionella pneumophila Philadelphia 1.Acta Crystallogr F Struct Biol Commun2023
35048450Structures of plasmepsin X from Plasmodium falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme.Protein Sci2022
35977963Structural characterization of aspartate-semialdehyde dehydrogenase from Pseudomonas aeruginosa and Neisseria gonorrhoeae.Sci Rep2022
36216349Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of <b>UCB7362</b>.J Med Chem2022
35245364Broad-spectrum in vitro activity of macrophage infectivity potentiator inhibitors against Gram-negative bacteria and Leishmania major.J Antimicrob Chemother2022
33446675Structural characterization of a GNAT family acetyltransferase from Elizabethkingia anophelis bound to acetyl-CoA reveals a new dimeric interface.Sci Rep2021
33760815Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba.PLoS One2021
33620038Crystal structure of acetoacetyl-CoA reductase from Rickettsia felis.Acta Crystallogr F Struct Biol Commun2021
33947893Structural characterization of a Type B chloramphenicol acetyltransferase from the emerging pathogen Elizabethkingia anophelis NUHP1.Sci Rep2021
32550996Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors.ACS Med Chem Lett2020
31930600Toward a structome of Acinetobacter baumannii drug targets.Protein Sci2020
31930578Structures of glyceraldehyde 3-phosphate dehydrogenase in Neisseria gonorrhoeae and Chlamydia trachomatis.Protein Sci2020
30894487Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.Proc Natl Acad Sci U S A2019
31484791Overcoming adaptive therapy resistance in AML by targeting immune response pathways.Sci Transl Med2019
30867460Crystal structures of thiamine monophosphate kinase from Acinetobacter baumannii in complex with substrates and products.Sci Rep2019
29633965Crystal structure of chorismate mutase from Burkholderia phymatum.Acta Crystallogr F Struct Biol Commun2018
30198884Ab initio structure solution of a proteolytic fragment using ARCIMBOLDO.Acta Crystallogr F Struct Biol Commun2018
27798837Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.ACS Infect Dis2017
28303005Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms.Sci Rep2017
28120876Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors.Sci Rep2017
28369538Structure of acid deoxyribonuclease.Nucleic Acids Res2017
27500735Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.PLoS One2016
26473983Some of the most interesting CASP11 targets through the eyes of their authors.Proteins2016
27658298Correction: Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.PLoS One2016
27357661Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.Proc Natl Acad Sci U S A2016
25613812Increasing the structural coverage of tuberculosis drug targets.Tuberculosis (Edinb)2015
25832174Crystal structures of Mycobacterial MeaB and MMAA-like GTPases.J Struct Funct Genomics2015
25945716Structures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP.Acta Crystallogr F Struct Biol Commun2015
25945711Structures of a histidine triad family protein from Entamoeba histolytica bound to sulfate, AMP and GMP.Acta Crystallogr F Struct Biol Commun2015
25945710Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia.Acta Crystallogr F Struct Biol Commun2015
25945709Structure of uridine diphosphate N-acetylglucosamine pyrophosphorylase from Entamoeba histolytica.Acta Crystallogr F Struct Biol Commun2015
25957961High-resolution Crystal Structure of Dimeric VP40 From Sudan ebolavirus.J Infect Dis2015
24318984Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th Critical Assessment of Techniques for Protein Structure Prediction Experiment CASP10.Proteins2014
25516846Tyrosine aminotransferase from Leishmania infantum: A new drug target candidate.Int J Parasitol Drugs Drug Resist2014
25089892Structural analysis of H1N1 and H7N9 influenza A virus PA in the absence of PB1.Sci Rep2014
24817714Structure of tyrosine aminotransferase from Leishmania infantum.Acta Crystallogr F Struct Biol Commun2014
24699737Structure of the Reston ebolavirus VP30 C-terminal domain.Acta Crystallogr F Struct Biol Commun2014
24366729A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.Antimicrob Agents Chemother2014
23407310Structure and function of a cyanophage-encoded peptide deformylase.ISME J2013
23851357Multi-target parallel processing approach for gene-to-structure determination of the influenza polymerase PB2 subunit.J Vis Exp2013
22927809Artificial neural networks trained to detect viral and phage structural proteins.PLoS Comput Biol2012
21904038Gene Composer in a structural genomics environment.Acta Crystallogr Sect F Struct Biol Cryst Commun2011
21904052Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis.Acta Crystallogr Sect F Struct Biol Cryst Commun2011
21904039Gene design, cloning and protein-expression methods for high-value targets at the Seattle Structural Genomics Center for Infectious Disease.Acta Crystallogr Sect F Struct Biol Cryst Commun2011
19383142Gene composer: database software for protein construct design, codon engineering, and gene synthesis.BMC Biotechnol2009
19383143Combined protein construct and synthetic gene engineering for heterologous protein expression and crystallization using Gene Composer.BMC Biotechnol2009
15528182Impact of the deltaF508 mutation in first nucleotide-binding domain of human cystic fibrosis transmembrane conductance regulator on domain folding and structure.J Biol Chem2005
16211523New York-Structural GenomiX Research Consortium (NYSGXRC): a large scale center for the protein structure initiative.J Struct Funct Genomics2005
16211509High-throughput limited proteolysis/mass spectrometry for protein domain elucidation.J Struct Funct Genomics2005
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Co-authored papers 2
University of Dundee
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Co-authored papers 2
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Albert Einstein College of Medicine
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Co-authored papers 2
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Co-authored papers 2
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Albert Einstein College of Medicine
Co-authored papers 1
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Temple University
Co-authored papers 1
a division of The Scripps Research Institute La Jolla
Co-authored papers 1
Brookhaven National Laboratory
Co-authored papers 1
Columbia University
Co-authored papers 1
National Center for Biotechnology Information, National Institutes of Health
Co-authored papers 1
Stanford University School of Medicine
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