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Author Details

Darell D Bigner
1969
658
118
PMIDPaper TitleJournal TitlePublished Year
36864784Polio virotherapy targets the malignant glioma myeloid infiltrate with diffuse microglia activation engulfing the CNS.2023
37760589Repurposing Clemastine to Target Glioblastoma Cell Stemness.Cancers (Basel)2023
36639156Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation.J Immunother Cancer2023
37072349Intratumor childhood vaccine-specific CD4 T-cell recall coordinates antitumor CD8 T cells and eosinophils.2023
36753564Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models.2023
37004712Recombinant polio-rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial.2023
35487217Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition.Cancer Cell2022
36175036Multimodality analysis confers a prognostic benefit of a T-cell infiltrated tumor microenvironment and peripheral immune status in patients with melanoma.Journal for ImmunoTherapy of Cancer2022
33767151Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling.Nature Communications2021
33875611Phase I trial of intratumoral PVSRIPO in patients with unresectable, treatment-refractory melanoma.Journal for ImmunoTherapy of Cancer2021
31988324Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity.Nature Communications2020
31040154MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation.Cancer Research2019
30500933MGMT: Immunohistochemical Detection in High-Grade Astrocytomas.Journal of Neuropathology and Experimental Neurology2019
30346624Sensitive and rapid detection of TERT promoter and IDH mutations in diffuse gliomas.Neuro-Oncology2019
30625226Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors.PLoS ONE2019
31142380Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations.Journal for ImmunoTherapy of Cancer2019
29802247The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.Nat Commun2018
30266879Correction: Reversing the Warburg effect as a treatment for glioblastoma.Journal of Biological Chemistry2018
30120661Bevacizumab, irinotecan, temozolomide, tyrosine kinase inhibition, and MEK inhibition are effective against pleomorphic xanthoastrocytoma regardless of V600E status.Journal of Neuro-Oncology2018
29878245Poliovirus Receptor (CD155) Expression in Pediatric Brain Tumors Mediates Oncolysis of Medulloblastoma and Pleomorphic Xanthoastrocytoma.J Neuropathol Exp Neurol2018
29872344Elevated expression of podoplanin and its clinicopathological, prognostic, and therapeutic values in squamous non-small cell lung cancer.Cancer Management and Research2018
30131529Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells.Sci Rep2018
29943666Recurrent Glioblastoma Treated with Recombinant Poliovirus.New England Journal of Medicine2018
29854587Application of mutagen sensitivity assay in a glioma case-control study.Toxicology Reports2018
29097607Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1-Induced Metabolic Liabilities.Cancer Research2018
29093005Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma.Cancer Research2018
29564747Sym004-induced EGFR elimination is associated with profound anti-tumor activity in EGFRvIII patient-derived glioblastoma models.Journal of Neuro-Oncology2018
29437767T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma.Clin Cancer Res2018
29703821A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma.Clinical Cancer Research2018
29115565AJAP1 expression modulates glioma cell motility and correlates with tumor growth and survival.International Journal of Oncology2018
28024998Development and validation of a cell-based fluorescent method for measuring antibody affinity.Journal of Immunological Methods2017
28379574The role of angiogenesis in Group 3 medulloblastoma pathogenesis and survival.Neuro Oncol2017
28981720Selection of novel affinity-matured human chondroitin sulfate proteoglycan 4 antibody fragments by yeast display.Protein Engineering, Design and Selection2017
28939681Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation.Cancer Research2017
28411277Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination.Clinical Cancer Research2017
28931654Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs.Science Translational Medicine2017
28829151Validation of an Immunohistochemistry Assay for Detection of CD155, the Poliovirus Receptor, in Malignant Gliomas.2017
29100338Patient-derived DIPG cells preserve stem-like characteristics and generate orthotopic tumors.Oncotarget2017
28013405Production and quality control assessment of a GLP-grade immunotoxin, D2C7-(scdsFv)-PE38KDEL, for a phase I/II clinical trial.Applied Microbiology and Biotechnology2017
28229994Immunotoxin Therapy for Lung Cancer.Chinese Medical Journal2017
28148827Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression.Molecular Cancer Research2017
27806313Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models.Oncotarget2016
26976201Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis.Lancet Oncol2016
27364552Rapid Reprogramming of Primary Human Astrocytes into Potent Tumor-Initiating Cells with Defined Genetic Factors.Cancer Research2016
26728879Preclinical toxicity evaluation of a novel immunotoxin, D2C7-(scdsFv)-PE38KDEL, administered via intracerebral convection-enhanced delivery in rats.Investigational New Drugs2016
26822025CAR T Cells Targeting Podoplanin Reduce Orthotopic Glioblastomas in Mouse Brains.Cancer Immunology Research2016
26766590MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B.Cancer Cell2016
27255663IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma.Sci Rep2016
28286803EGFR/EGFRvIII-targeted immunotoxin therapy for the treatment of glioblastomas via convection-enhanced delivery.2016
26061751Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.N Engl J Med2015
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