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Author Details

Eszter Farkas
Hungarian Centre of Excellence for Molecular Medicine-University of Szeged
1996
95
41
PMIDPaper TitleJournal TitlePublished Year
36810711Nimodipine accelerates the restoration of functional hyperemia during spreading oligemia.J Neurochem2024
36703609Spreading depolarization causes reperfusion failure after cerebral ischemia.J Cereb Blood Flow Metab2023
37181624Nimodipine augments cerebrovascular reactivity in aging but runs the risk of local perfusion reduction in acute cerebral ischemia.Front Aging Neurosci2023
34427145Malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci.J Cereb Blood Flow Metab2022
35257321The Critical Role of Spreading Depolarizations in Early Brain Injury: Consensus and Contention.Neurocrit Care2022
34855119Transient Hypoperfusion to Ischemic/Anoxic Spreading Depolarization is Related to Autoregulatory Failure in the Rat Cerebral Cortex.Neurocrit Care2022
35201268Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions.J Exp Med2022
35194729Questioning Glutamate Excitotoxicity in Acute Brain Damage: The Importance of Spreading Depolarization.Neurocrit Care2022
34023338N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain.Neuropharmacology2021
33810538Astrocyte Ca<sup>2+</sup> Waves and Subsequent Non-Synchronized Ca<sup>2+</sup> Oscillations Coincide with Arteriole Diameter Changes in Response to Spreading Depolarization.Int J Mol Sci2021
33941084Comparative analysis of spreading depolarizations in brain slices exposed to osmotic or metabolic stress.BMC Neurosci2021
31388871Which Spreading Depolarizations Are Deleterious To Brain Tissue?Neurocrit Care2020
32056076Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects.Geroscience2020
31991249The antagonism of prostaglandin FP receptors inhibits the evolution of spreading depolarization in an experimental model of global forebrain ischemia.Neurobiol Dis2020
31987008Microglia alter the threshold of spreading depolarization and related potassium uptake in the mouse brain.J Cereb Blood Flow Metab2020
31715193Chitosan nanoparticles release nimodipine in response to tissue acidosis to attenuate spreading depolarization evoked during forebrain ischemia.Neuropharmacology2020
33322264Tissue Acidosis Associated with Ischemic Stroke to Guide Neuroprotective Drug Delivery.Biology (Basel)2020
32942106Heart-cutting two-dimensional liquid chromatography coupled to quadrupole-orbitrap high resolution mass spectrometry for determination of N,N-dimethyltryptamine in rat plasma and brain; Method development and application.J Pharm Biomed Anal2020
32236824Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain.Geroscience2020
30336178Susceptibility of the cerebral cortex to spreading depolarization in neurological disease states: The impact of aging.Neurochem Int2019
31780917Aging Impairs Cerebrovascular Reactivity at Preserved Resting Cerebral Arteriolar Tone and Vascular Density in the Laboratory Rat.Front Aging Neurosci2019
31691147Cerebral venous congestion promotes blood-brain barrier disruption and neuroinflammation, impairing cognitive function in mice.Geroscience2019
31679124Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging.Geroscience2019
31463647Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects.Geroscience2019
31015147Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice.Redox Biol2019
30737967The impact of dihydropyridine derivatives on the cerebral blood flow response to somatosensory stimulation and spreading depolarization.Br J Pharmacol2019
31144244Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment.Geroscience2019
30848677Role of age-related alterations of the cerebral venous circulation in the pathogenesis of vascular cognitive impairment.Am J Physiol Heart Circ Physiol2019
30875255Role of endothelial NAD<sup>+</sup> deficiency in age-related vascular dysfunction.Am J Physiol Heart Circ Physiol2019
29405550Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice.Aging Cell2018
30053571Large-conductance Ca<sup>2+</sup>-activated potassium channels are potently involved in the inverse neurovascular response to spreading depolarization.Neurobiol Dis2018
30026092Preparation of novel tissue acidosis-responsive chitosan drug nanoparticles: Characterization and in vitro release properties of Ca<sup>2+</sup> channel blocker nimodipine drug molecules.Eur J Pharm Sci2018
29905772Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype.J Gerontol A Biol Sci Med Sci2018
30470983Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation.Geroscience2018
30467480Spectral and Multifractal Signature of Cortical Spreading Depolarisation in Aged Rats.Front Physiol2018
29468558Correction to: Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice.Geroscience2018
27317657Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group.J Cereb Blood Flow Metab2017
28299642Cerebromicrovascular dysfunction predicts cognitive decline and gait abnormalities in a mouse model of whole brain irradiation-induced accelerated brain senescence.Geroscience2017
28442781Spreading depolarization remarkably exacerbates ischemia-induced tissue acidosis in the young and aged rat brain.Sci Rep2017
29243191Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice.Geroscience2017
28600353Age or ischemia uncouples the blood flow response, tissue acidosis, and direct current potential signature of spreading depolarization in the rat brain.Am J Physiol Heart Circ Physiol2017
28578467Demonstration of impaired neurovascular coupling responses in TG2576 mouse model of Alzheimer's disease using functional laser speckle contrast imaging.Geroscience2017
28546077Systemic administration of l-kynurenine sulfate induces cerebral hypoperfusion transients in adult C57Bl/6 mice.Microvasc Res2017
27328690The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão's legacy.J Cereb Blood Flow Metab2017
27189902Advancing age and ischemia elevate the electric threshold to elicit spreading depolarization in the cerebral cortex of young adult rats.J Cereb Blood Flow Metab2017
27506382Contribution of prostanoid signaling to the evolution of spreading depolarization and the associated cerebral blood flow response.Sci Rep2016
27614225Traumatic brain injury-induced autoregulatory dysfunction and spreading depression-related neurovascular uncoupling: Pathomechanisms, perspectives, and therapeutic implications.Am J Physiol Heart Circ Physiol2016
25720414Is Vasomotion in Cerebral Arteries Impaired in Alzheimer's Disease?J Alzheimers Dis2015
26346140High incidence of adverse cerebral blood flow responses to spreading depolarization in the aged ischemic rat brain.Neurobiol Aging2015
26311408Vascular dysfunction in the pathogenesis of Alzheimer's disease--A review of endothelium-mediated mechanisms and ensuing vicious circles.Neurobiol Dis2015
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Collaborators

Center for Stroke Research Berlin, Charite University
Co-authored papers 7
University of Cincinnati
Co-authored papers 6
University of Utah School of Medicine
Co-authored papers 5
Medical College of Georgia at Augusta University
Co-authored papers 5
German Cancer Research Center (DKFZ)
Co-authored papers 5
Neurovascular Research Unit, Massachusetts General Hospital, Harvard Medical School
Co-authored papers 5
Queen's University
Co-authored papers 5
Cajal Institute-CSIC
Co-authored papers 3
Imperial College London
Co-authored papers 3
Evangelisches Krankenhaus, Carl von Ossietzky University Oldenburg
Co-authored papers 3
University of Cincinnati
Co-authored papers 3
Copenhagen University Hospital - Rigshospitalet
Co-authored papers 3
Medical University of Innsbruck
Co-authored papers 3
University of New Mexico School of Medicine
Co-authored papers 3
Beth Israel Deaconess Medical Center, Division of Neurocritical Care and Emergency Neurology, Division of Clinical Neurophysiology, Massachusetts General Hospital, Boston, MA, Harvard Medical School, Massachusetts General Hospital, Massachusetts General Hospital Fellowship in Epilepsy and Clinical Neurophysiology, Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School Fellowship Training Program in Neurocritical Care, Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School Partners Neurology Residency Training Program, Yale College
Co-authored papers 3
Queen's University
Co-authored papers 3
Center for Stroke Research Berlin
Co-authored papers 3
University of New Mexico
Co-authored papers 3
Heidelberg University Hospital, Ruprecht Karls University of Heidelberg
Co-authored papers 2
Interuniversity Microelectronics Centre
Co-authored papers 2
1 Center for Stroke Research Berlin, Charite University Medicine Berlin
Co-authored papers 2
Jena University Hospital - Friedrich Schiller University of Jena
Co-authored papers 2
Co-authored papers 2
University of Gothenburg
Co-authored papers 2
Vagalume LLC
Co-authored papers 2
Max-Planck-Institute for Neurological Research
Co-authored papers 2
Rigshospitalet, University of Copenhagen
Co-authored papers 2
Department of Basic and Clinical Neuroscience, King's College London
Co-authored papers 2
Imperial College London
Co-authored papers 2
University of Pittsburgh Medical Center
Co-authored papers 2