Author details

Full Name

Duilio Cascio

Affiliation

ORCID

Career Start Year

1983

Papers

177

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
38072051	Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.	J Biol Chem	2024
36693107	The Shr receptor from <i>Streptococcus pyogenes</i> uses a cap and release mechanism to acquire heme-iron from human hemoglobin.	Proc Natl Acad Sci U S A	2023
37669364	Cryo-EM structure determination of small therapeutic protein targets at 3 Ã¿-resolution using a rigid imaging scaffold.		2023
37729854	Development and atomic structure of a new fluorescence-based sensor to probe heme transfer in bacterial pathogens.		2023
37801475	Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.	Proc Natl Acad Sci U S A	2023
37185252	Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils.	Nat Commun	2023
35194841	The structure of the Clostridium thermocellum RsgI9 ectodomain provides insight into the mechanism of biomass sensing.	Proteins: Structure, Function and Bioinformatics	2022
35690147	Crystal structure of mevalonate 3,5-bisphosphate decarboxylase reveals insight into the evolution of decarboxylases in the mevalonate metabolic pathways.	Journal of Biological Chemistry	2022
35377792	Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation.	Proc Natl Acad Sci U S A	2022
35988647	Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like Î²-sheets.	J Biol Chem	2022
34864059	Insight into the molecular basis of substrate recognition by the wall teichoic acid glycosyltransferase TagA.	J Biol Chem	2022
33406362	Isolation and X-ray Crystal Structure of an Electrogenerated TEMPO-N Charge-Transfer Complex.	Organic Letters	2021
34076594	Structure of human factor VIIa-soluble tissue factor with calcium, magnesium and rubidium.	Acta Crystallographica Section D: Structural Biology	2021
33688654	Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2.	bioRxiv	2021
34312563	Prospecting for natural products by genome mining and microcrystal electron diffraction.	Nature Chemical Biology	2021
32796831	CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid.	Nat Commun	2020
32123169	Serial femtosecond crystallography on in vivo-grown crystals drives elucidation of mosquitocidal Cyt1Aa bioactivation cascade.	Nat Commun	2020
32493775	Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.	J Biol Chem	2020
31530939	Author Correction: Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.	Nat Struct Mol Biol	2019
31572777	Characterization of Reactive Organometallic Species via MicroED.	ACS Central Science	2019
31616952	Cooperative DNA binding by proteins through DNA shape complementarity.	Nucleic Acids Research	2019
31612856	Structure-based inhibitors of amyloid beta core suggest a common interface with tau.	Elife	2019
30559425	Structural basis of 7SK RNA 5'-Î³-phosphate methylation and retention by MePCE.	Nature Chemical Biology	2019
30867917	Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ.	IUCrJ	2019
31002736	Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria.	PLoS Pathogens	2019
31350392	Structure of amyloid-Î² (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.	Nat Commun	2019
31537646	Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples.	J Biol Chem	2019
29359764	Structure-based inhibitors of tau aggregation.	Nat Chem	2018
30301765	The Shr protein captures human hemoglobin using two structurally unique binding domains.	Journal of Biological Chemistry	2018
30289389	Multiple serine transposase dimers assemble the transposon-end synaptic complex during IS-family transposition.	eLife	2018
30524935	Protein structural biology using cell-free platform from wheat germ.	Advanced Structural and Chemical Imaging	2018
29717712	Microfocus diffraction from different regions of a protein crystal: structural variations and unit-cell polymorphism.	Acta Crystallogr D Struct Biol	2018
29531287	Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2.	Nat Struct Mol Biol	2018
29439243	Atomic structures of low-complexity protein segments reveal kinked Î² sheets that assemble networks.	Science	2018
29335561	Sub-Ã¥ngstrÃ¶m cryo-EM structure of a prion protofibril reveals a polar clasp.	Nat Struct Mol Biol	2018
29290488	Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6.	Structure	2018
29282295	Common fibrillar spines of amyloid-Î² and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.	J Biol Chem	2018
29786080	Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.	Nat Struct Mol Biol	2018
28192420	Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.	Nat Methods	2017
28338692	Computational design of self-assembling cyclic protein homo-oligomers.	Nat Chem	2017
28574190	Flow-aligned, single-shot fiber diffraction using a femtosecond X-ray free-electron laser.	Cytoskeleton (Hoboken)	2017
28479252	Crystal structure of Mdm12 and combinatorial reconstitution of Mdm12/Mmm1 ERMES complexes for structural studies.	Biochemical and Biophysical Research Communications	2017
28045370	Atomic structures of fibrillar segments of hIAPP suggest tightly mated Î²-sheets are important for cytotoxicity.	Elife	2017
27721416	Characterization of WY 14,643 and its Complex with Aldose Reductase.	Scientific Reports	2016
26959646	DNA Sequence Determinants Controlling Affinity, Stability and Shape of DNA Complexes Bound by the Nucleoid Protein Fis.	PLoS ONE	2016
27464895	A PII-Like Protein Regulated by Bicarbonate: Structural and Biochemical Studies of the Carboxysome-Associated CPII Protein.	Journal of Molecular Biology	2016
27463675	Accurate design of megadalton-scale two-component icosahedral protein complexes.	Science	2016
26701219	Structure of a putative ClpS N-end rule adaptor protein from the malaria pathogen Plasmodium falciparum.	Protein Science	2016
26689263	Engineering an allosteric transcription factor to respond to new ligands.	Nat Methods	2016
27936128	Crystal Structure of the Streptomyces coelicolor Sortase E1 Transpeptidase Provides Insight into the Binding Mode of the Novel Class E Sorting Signal.	PLoS ONE	2016