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Author Details

David Maag
2000
47
33
PMIDPaper TitleJournal TitlePublished Year
35093516Long-term efficacy and safety of addition of carboplatin with or without veliparib to standard neoadjuvant chemotherapy in triple-negative breast cancer: 4-year follow-up data from BrighTNess, a randomized phase III trial.Annals of Oncology2022
34861374Veliparib monotherapy following carboplatin/paclitaxel plus veliparib combination therapy in patients with germline BRCA-associated advanced breast cancer: results of exploratory analyses from the phase III BROCADE3 trial.Annals of Oncology2022
34764307Matched cohort study of germline BRCA mutation carriers with triple negative breast cancer in brightness.NPJ Breast Cancer2021
34243076Efficacy and safety of first-line veliparib and carboplatin-paclitaxel in patients with HER2- advanced germline BRCA+ breast cancer: Subgroup analysis of a randomised clinical trial.European Journal of Cancer2021
34131001Relevance of Platinum-free Interval and <i>BRCA</i> Reversion Mutations for Veliparib Monotherapy after Progression on Carboplatin/Paclitaxel for g<i>BRCA</i> Advanced Breast Cancer (BROCADE3 Crossover).Clin Cancer Res2021
33823285Rovalpituzumab Tesirine as a Maintenance Therapy After First-Line Platinum-Based Chemotherapy in Patients With Extensive-Stage-SCLC: Results From the Phase 3 MERU Study.Journal of Thoracic Oncology2021
33652156A Phase 1-2 Study of Rovalpituzumab Tesirine in Combination With Nivolumab Plus or Minus Ipilimumab in Patients With Previously Treated Extensive-Stage SCLC.J Thorac Oncol2021
33599688Association of Immunophenotype With Pathologic Complete Response to Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer: A Secondary Analysis of the BrighTNess Phase 3 Randomized Clinical Trial.JAMA Oncol2021
34917174Safety and efficacy of veliparib plus carboplatin/paclitaxel in patients with HER2-negative metastatic or locally advanced breast cancer: subgroup analyses by germline / mutations and hormone receptor status from the phase-3 BROCADE3 trial.Therapeutic Advances in Medical Oncology2021
34549181Tumor volumes as a predictor of response to the anti-EGFR antibody drug conjugate depatuxizumab mafadotin.Neurooncol Adv2021
32861273Veliparib with carboplatin and paclitaxel in BRCA-mutated advanced breast cancer (BROCADE3): a randomised, double-blind, placebo-controlled, phase 3 trial.Lancet Oncology, The2020
31913413Breast Conservation After Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer: Surgical Results From the BrighTNess Randomized Clinical Trial.JAMA Surgery2020
31926787Corrigendum to "Investigation of biaryl heterocycles as inhibitors of Wee1 kinase" [Bioorg. Med. Chem. Lett. 29 (2019) 1481-1486].Bioorganic and Medicinal Chemistry Letters2020
31606288Early assessment with magnetic resonance imaging for prediction of pathologic response to neoadjuvant chemotherapy in triple-negative breast cancer: Results from the phase III BrighTNess trial.European Journal of Surgical Oncology2020
30796037Comparison of Biomarker Assays for <i>EGFR</i>: Implications for Precision Medicine in Patients with Glioblastoma.Clin Cancer Res2019
29982805Safety and efficacy of depatuxizumab mafodotin + temozolomide in patients with EGFR-amplified, recurrent glioblastoma: results from an international phase I multicenter trial.Neuro Oncol2019
30429212PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow.Molecular Cancer Research2019
29501363Addition of the PARP inhibitor veliparib plus carboplatin or carboplatin alone to standard neoadjuvant chemotherapy in triple-negative breast cancer (BrighTNess): a randomised, phase 3 trial.Lancet Oncology, The2018
28135237The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.Nat Chem Biol2017
28468779Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors.Molecular Cancer Therapeutics2017
28853738Erratum: The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.Nat Chem Biol2017
28610984SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).Bioorganic and Medicinal Chemistry Letters2017
29075855Efficacy of depatuxizumab mafodotin (ABT-414) monotherapy in patients with EGFR-amplified, recurrent glioblastoma: results from a multi-center, international study.Cancer Chemother Pharmacol2017
27739325A randomized Phase II study of veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in BRCA1/2 metastatic breast cancer: design and rationale.Future Oncol2017
26101576Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2.ACS Med Chem Lett2015
25589931Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase.ACS Medicinal Chemistry Letters2015
26217019Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors.Molecular Cancer Research2015
24900801Discovery and development of potent and selective inhibitors of histone methyltransferase g9a.ACS Medicinal Chemistry Letters2014
22128301Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor.Clinical Cancer Research2012
21284988Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase.Cell Metab2011
21220345Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB.Proc Natl Acad Sci U S A2011
21145457Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain.Cell2010
19193859Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition.Proceedings of the National Academy of Sciences of the United States of America2009
18455988Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1.Cell2008
17434125The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome.Molecular Cell2007
17332751N- and C-terminal residues of eIF1A have opposing effects on the fidelity of start codon selection.EMBO J2007
17504939Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo.Genes Dev2007
17189426Intragenic suppressor mutations restore GTPase and translation functions of a eukaryotic initiation factor 5B switch II mutant.Molecular and Cellular Biology2007
16380131Communication between eukaryotic translation initiation factors 5 and 1A within the ribosomal pre-initiation complex plays a role in start site selection.Journal of Molecular Biology2006
16246727Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiation.Molecular Cell2005
15664195A conformational change in the eukaryotic translation preinitiation complex and release of eIF1 signal recognition of the start codon.Molecular Cell2005
12860115Communication between eukaryotic translation initiation factors 1 and 1A on the yeast small ribosomal subunit.Journal of Molecular Biology2003
12008673Development and characterization of a reconstituted yeast translation initiation system.RNA2002
12507428Uncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinity.Cell2002
11602568Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin.Journal of Biological Chemistry2001
11100123The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen.Nat Med2000
10982360Template/primer requirements and single nucleotide incorporation by hepatitis C virus nonstructural protein 5B polymerase.Journal of Virology2000
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