Author details

Full Name

Arun K Shukla

Affiliation

ORCID

Career Start Year

2006

Papers

100

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37244255	A key GPCR phosphorylation motif discovered in arrestin2â¿¿CCR5 phosphopeptide complexes.	Mol Cell	2023
36057461	Structural snapshot of a Î²-arrestin-biased receptor.	Trends in Pharmacological Sciences	2023
37558722	Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system.		2023
37209686	Structural snapshots uncover a key phosphorylation motif in GPCRs driving Î²-arrestin activation.		2023
37146613	Plasma membrane preassociation drives Î²-arrestin coupling to receptors and activation.		2023
36948711	A streamlined protocol for expression and purification of wild-type Î²-arrestins.		2023
35106752	Community guidelines for GPCR ligand bias: IUPHAR review 32.	Br J Pharmacol	2022
35393664	Targeting the cell's gatekeepers for novel drug discovery.	British Journal of Pharmacology	2022
35623708	In-cellulo chemical cross-linking to visualize protein-protein interactions.	Methods in Cell Biology	2022
35623705	An intrabody sensor to monitor conformational activation of Î²-arrestins.	Methods in Cell Biology	2022
35738165	Emerging structural insights into GPCR-Î²-arrestin interaction and functional outcomes.	Current Opinion in Structural Biology	2022
36113411	Resonating with the signaling bias of CXCR7.	Molecular Cell	2022
35316098	Making the switch: The role of Gq in driving GRK selectivity at GPCRs.	Science Signaling	2022
35046612	Scratching the itch with cryo-EM.	Nature Chemical Biology	2022
34887409	Biphasic activation of Î²-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR.	Nature Communications	2021
33785921	Feeling at home: Structure of the NTSR1-G complex in a lipid environment.	Nature Structural and Molecular Biology	2021
33985815	Structural insights into ligand recognition and activation of angiotensin receptors.	Trends in Pharmacological Sciences	2021
33824179	Biased ligands at opioid receptors: Current status and future directions.	Sci Signal	2021
33818907	Emerging paradigms in activation, signaling, and regulation of G protein-coupled receptors.		2021
32715625	Key phosphorylation sites in GPCRs orchestrate the contribution of Î²-Arrestin 1 in ERK1/2 activation.	EMBO Reports	2020
32145391	Purification of native CCL7 and its functional interaction with selected chemokine receptors.	Protein Expression and Purification	2020
32402749	Emerging Insights into the Structure and Function of Complement C5a Receptors.	Trends in Biochemical Sciences	2020
32169216	Terminating G-Protein Coupling: Structural Snapshots of GPCR-Î²-Arrestin Complexes.	Cell	2020
32046851	Reversible biotinylation of purified proteins for measuring protein-protein interactions.	Methods in Enzymology	2020
32046850	Site-directed labeling of Î²-arrestin with monobromobimane for measuring their interaction with G protein-coupled receptors.	Methods in Enzymology	2020
32089163	Structure and function of Î²-arrestins, their emerging role in breast cancer, and potential opportunities for therapeutic manipulation.		2020
32439801	Genetically encoded intrabody sensors report the interaction and trafficking of Î²-arrestin 1 upon activation of G-protein-coupled receptors.	J Biol Chem	2020
32327587	Calcium as a biased cofactor.	Science	2020
31702904	The Inside Story: Crystal Structure of the Chemokine Receptor CCR7 with an Intracellular Allosteric Antagonist.	Biochemistry	2020
32917711	Distinct phosphorylation sites in a prototypical GPCR differently orchestrate Î²-arrestin interaction, trafficking, and signaling.	Science advances	2020
32579945	Crystal Structure of Î²-Arrestin 2 in Complex with CXCR7 Phosphopeptide.	Structure	2020
33023856	The Complement C5a-C5aR1 GPCR Axis in COVID-19 Therapeutics.	Trends in Immunology	2020
33007256	Transmitting the Signal: Structure of the Î²1-Adrenergic Receptor-Gs Protein Complex.	Molecular Cell	2020
32555462	Molecular basis of Î²-arrestin coupling to formoterol-bound Î²-adrenoceptor.	Nature	2020
31415748	The Gut Feeling: GPCRs Enlighten the Way.		2019
31553900	Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between Î²-Arrestin Isoforms.	Cell Reports	2019
30596501	Structural Basis of Partial Agonism at the Î²2-Adrenergic Receptor.	Biochemistry	2019
30616816	Measuring agonist-induced ERK MAP kinase phosphorylation for G-protein-coupled receptors.	Methods in Cell Biology	2019
30616815	Measuring surface expression and endocytosis of GPCRs using whole-cell ELISA.	Methods in Cell Biology	2019
29735399	Emerging Paradigm of Intracellular Targeting of G Protein-Coupled Receptors.	Trends Biochem Sci	2018
29872229	Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation.	Nat Struct Mol Biol	2018
30290148	Entering the Pocket: Crystal Structure of a Prostaglandin D2 Receptor.	Molecular Cell	2018
29945844	Illuminating GPCR Signaling by Cryo-EM.	Trends in Cell Biology	2018
29101002	Cellular Signalling - Special issue to celebrate 75th birthday of Prof. Robert J. Lefkowitz.	Cellular Signalling	2018
29614294	GPCR Signaling: The Interplay of GÎ±i and Î²-arrestin.	Current Biology	2018
28223524	Distinct conformations of GPCR-Î²-arrestin complexes mediate desensitization, signaling, and endocytosis.	Proc Natl Acad Sci U S A	2017
28950953	Preface.	Advances in Immunology	2017
28586324	Frozen in action: cryo-EM structure of a GPCR-G-protein complex.	Nature Structural and Molecular Biology	2017
28967893	A synthetic intrabody-based selective and generic inhibitor of GPCR endocytosis.	Nat Nanotechnol	2017
28651823	Novel Structural Insights into GPCR-Î²-Arrestin Interaction and Signaling.	Trends in Cell Biology	2017