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Author Details

Richard O Hynes
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
1970
377
134
PMIDPaper TitleJournal TitlePublished Year
37098922Proteomic Profiling of Extracellular Matrix Components from Patient Metastases Identifies Consistently Elevated Proteins for Developing Nanobodies That Target Primary Tumors and Metastases.Cancer Res2023
34785582Agrin Loss in Barrett's Esophagus-Related Neoplasia and Its Utility as a Diagnostic and Predictive Biomarker.Clin Cancer Res2022
36712341Intratumoral nanobody-IL-2 fusions that bind the tumor extracellular matrix suppress solid tumor growth in mice.PNAS Nexus2022
35013154Maximizing response to intratumoral immunotherapy in mice by tuning local retention.Nat Commun2022
33012048Knockout of the gene encoding the extracellular matrix protein SNED1 results in early neonatal lethality and craniofacial malformations.Dev Dyn2021
33879793Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells.Nat Commun2021
33207933Alternative Splicing of FN (Fibronectin) Regulates the Composition of the Arterial Wall Under Low Flow.Arterioscler Thromb Vasc Biol2021
32744761α<sub>V</sub> integrins in Schwann cells promote attachment to axons, but are dispensable in vivo.Glia2021
32591412YAP Enhances Tumor Cell Dissemination by Promoting Intravascular Motility and Reentry into Systemic Circulation.Cancer Res2020
32029550Cancer Cell-Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma.Cancer Res2020
32051509The scaffold protein IQGAP1 is crucial for extravasation and metastasis.Sci Rep2020
32019869Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches.Cancer Res2020
31852835Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions.Clin Cancer Res2020
33095048Reactions to the National Academies/Royal Society Report on <i>Heritable Human Genome Editing</i>.CRISPR J2020
30559289SRC tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis.J Biol Chem2019
31484774Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells.Proc Natl Acad Sci U S A2019
31068469Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix.Proc Natl Acad Sci U S A2019
30936321Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice.Proc Natl Acad Sci U S A2019
29293084Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow.Elife2018
29915060Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation.Proc Natl Acad Sci U S A2018
29730502Antibodies and methods for immunohistochemistry of extracellular matrix proteins.Matrix Biol2018
29539586Nephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs.Neoplasia2018
28071719Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.Sci Rep2017
28459449In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis.Nat Biotechnol2017
28254888Evolving policy with science.Science2017
28327460Comprehensive proteomic characterization of stem cell-derived extracellular matrices.Biomaterials2017
28473400Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses.J Exp Med2017
28122739The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy.Blood2017
28395003Toward Responsible Human Genome Editing.JAMA2017
28344315Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.Leukemia2017
29220013Corrigendum: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis.Nat Biotechnol2017
29191879Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF<sup>high</sup> neutrophils.Science2017
28946867Intravital imaging of metastasis in adult Zebrafish.BMC Cancer2017
28652369Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival.Proc Natl Acad Sci U S A2017
28675934Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.J Proteome Res2017
28667352Endothelium-derived fibronectin regulates neonatal vascular morphogenesis in an autocrine fashion.Angiogenesis2017
27872091Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways.Cancer Res2017
26163349The extracellular matrix: Tools and insights for the "omics" era.Matrix Biol2016
27829148PF4 Promotes Platelet Production and Lung Cancer Growth.Cell Rep2016
26965188αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells.Nat Commun2016
26988988Elucidation of the Roles of Tumor Integrin β1 in the Extravasation Stage of the Metastasis Cascade.Cancer Res2016
26872698Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy.Immunity2016
26996666Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE.Oncogene2016
26811325Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression.Cancer Discov2016
25807551Tumor angiogenesis in the absence of fibronectin or its cognate integrin receptors.PLoS One2015
26273955Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis.J Vis Exp2015
26282170A Quantitative System for Studying Metastasis Using Transparent Zebrafish.Cancer Res2015
26679988Deformability of Tumor Cells versus Blood Cells.Sci Rep2015
25670798α5 and αv integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo.Development2015
24618895Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters.Elife2014
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Collaborators

Paul S Frenette
Co-authored papers 18
Alexandra Naba
College of Medicine, University of Illinois at Chicago
Co-authored papers 15
Charles A Whittaker
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Co-authored papers 14
Karl R Clauser
Co-authored papers 10
Steven A Carr
Broad Institute of MIT and Harvard
Co-authored papers 9
Mollie Ullman-Cullere
Dana-Farber Cancer Institute and Partners Healthcare
Co-authored papers 7
Tyler Jacks
Co-authored papers 5
Robert Langer
Co-authored papers 4
Douglas A Lauffenburger
Massachusetts Institute of Technology
Co-authored papers 3
Benjamin Geiger
Co-authored papers 3
Dyann F Wirth
The Broad Institute
Co-authored papers 3
Deepak Mani
Co-authored papers 2
Huiming Ding
Massachusetts Institute of Technology
Co-authored papers 2
Bruce P Brandhorst
University Drive Simon Fraser University
Co-authored papers 2
Thomas A Rando
Stanford University
Co-authored papers 2
David T Scadden
Co-authored papers 2
Robert D Burke
University of Victoria
Co-authored papers 2
Tuomas Tammela
Memorial Sloan Kettering Cancer Center
Co-authored papers 2
Sangeeta N Bhatia
Brigham and Women's Hospital and Harvard Medical School
Co-authored papers 2
James R Whittle
Walter and Eliza Hall Institute of Medical Research
Co-authored papers 2
Qi Zhao
Yunnan Institute of Tropical Crops
Co-authored papers 2
Adam J Bass
Co-authored papers 2
Susan E Crawford
NorthShore University HealthSystem, Research Institute, 1001 University Place
Co-authored papers 2
Karl-F Bergeron
Universite du Quebec a Montreal (UQAM)
Co-authored papers 2
Monte M Winslow
Stanford University School of Medicine
Co-authored papers 2
Olga Ermolaeva
National Center for Biotechnology Information, National Institutes of Health
Co-authored papers 1
Sandra Hines
Eastern Michigan University.
Co-authored papers 1
Arthur L Caplan
Division of Medical Ethics, New York University Grossman School of Medicine
Co-authored papers 1
Carolyn Riley Chapman
Center for Human Genetics and Genomics, NYU Grossman School of Medicine
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Harvard Medical School
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Release 1.2