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Author Details

Bree B Aldridge
Tufts University School of Engineering
2006
47
22
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36733851Tools to develop antibiotic combinations that target drug tolerance in <i>Mycobacterium tuberculosis</i>.Front Cell Infect Microbiol2023
37549035Semi-automated colony-forming unit counting for biosafety level 3 laboratories.STAR Protoc2023
37278639Novel Synergies and Isolate Specificities in the Drug Interaction Landscape of Mycobacterium abscessus.Antimicrob Agents Chemother2023
37292927<i>Mycobacterium tuberculosis</i> grows linearly at the single-cell level with larger variability than model organisms.bioRxiv2023
36538813Advances in the design of combination therapies for the treatment of tuberculosis.Expert Opin Drug Discov2023
34599873Identification of cell wall synthesis inhibitors active against Mycobacterium tuberculosis by competitive activity-based protein profiling.Cell Chem Biol2022
35365812Types and functions of heterogeneity in mycobacteria.Nat Rev Microbiol2022
35590245Localization of EccA<sub>3</sub> at the growing pole in Mycobacterium smegmatis.BMC Microbiol2022
36480634Tuberculosis treatment failure associated with evolution of antibiotic resilience.Science2022
36549272How can systems approaches help us understand and treat infectious disease?Cell Syst2022
36714853C25-modified rifamycin derivatives with improved activity against <i>Mycobacterium abscessus</i>.PNAS Nexus2022
36084643Design principles to assemble drug combinations for effective tuberculosis therapy using interpretable pairwise drug response measurements.Cell Rep Med2022
34226736The Tuberculosis Drug Accelerator at year 10: what have we learned?Nat Med2021
34469743Systematic measurement of combination-drug landscapes to predict in vivo treatment outcomes for tuberculosis.Cell Syst2021
34628295Leveraging laboratory and clinical studies to design effective antibiotic combination therapy.Curr Opin Microbiol2021
34235676Efficient Measurement of Drug Interactions with DiaMOND (Diagonal Measurement of N-Way Drug Interactions).Methods Mol Biol2021
34228540Pharmacokinetics and Target Attainment of SQ109 in Plasma and Human-Like Tuberculosis Lesions in Rabbits.Antimicrob Agents Chemother2021
32680963Morphological profiling of tubercle bacilli identifies drug pathways of action.Proc Natl Acad Sci U S A2020
31808676Setting Our Sights on Infectious Diseases.ACS Infect Dis2020
32860732Multiscale Model Identifies Improved Schedule for Treatment of Acute Myeloid Leukemia In Vitro With the Mcl-1 Inhibitor AZD5991.CPT Pharmacometrics Syst Pharmacol2020
30699106Prediction of ultra-high-order antibiotic combinations based on pairwise interactions.PLoS Comput Biol2019
31719182Transcriptomic Signatures Predict Regulators of Drug Synergy and Clinical Regimen Efficacy against Tuberculosis.mBio2019
31249047Targeting drugs for tuberculosis.Science2019
30980069Definitions and guidelines for research on antibiotic persistence.Nat Rev Microbiol2019
31036919Publisher Correction: Definitions and guidelines for research on antibiotic persistence.Nat Rev Microbiol2019
29269274Engineered cell and tissue models of pulmonary fibrosis.Adv Drug Deliv Rev2018
29362232Stress-Induced Reorganization of the Mycobacterial Membrane Domain.mBio2018
29661879Accelerating Early Antituberculosis Drug Discovery by Creating Mycobacterial Indicator Strains That Predict Mode of Action.Antimicrob Agents Chemother2018
29619019Stable Regulation of Cell Cycle Events in Mycobacteria: Insights From Inherently Heterogeneous Bacterial Populations.Front Microbiol2018
29026882Efficient measurement and factorization of high-order drug interactions in <i>Mycobacterium tuberculosis</i>.Sci Adv2017
29209302Influence of Stress and Antibiotic Resistance on Cell-Length Distribution in <i>Mycobacterium tuberculosis</i> Clinical Isolates.Front Microbiol2017
29107550A Parallel Adder Coordinates Mycobacterial Cell-Cycle Progression and Cell-Size Homeostasis in the Context of Asymmetric Growth and Organization.Curr Biol2017
29176877Rv0004 is a new essential member of the mycobacterial DNA replication machinery.PLoS Genet2017
27114527Spatially distinct and metabolically active membrane domain in mycobacteria.Proc Natl Acad Sci U S A2016
27357669Temporal and intrinsic factors of rifampicin tolerance in mycobacteria.Proc Natl Acad Sci U S A2016
25016173Microbial metabolomics: innovation, application, insight.Curr Opin Microbiol2014
26104360The Spectrum of Drug Susceptibility in Mycobacteria.Microbiol Spectr2014
25233380Exploitation of Mycobacterium tuberculosis reporter strains to probe the impact of vaccination at sites of infection.PLoS Pathog2014
23468634Protein complexes and proteolytic activation of the cell wall hydrolase RipA regulate septal resolution in mycobacteria.PLoS Pathog2013
22174129Asymmetry and aging of mycobacterial cells lead to variable growth and antibiotic susceptibility.Science2012
22233444Polar assembly and scaffolding proteins of the virulence-associated ESX-1 secretory apparatus in mycobacteria.Mol Microbiol2012
22108795Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis.Mol Syst Biol2011
19343194Fuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/insulin-induced signaling.PLoS Comput Biol2009
18406323Quantitative analysis of pathways controlling extrinsic apoptosis in single cells.Mol Cell2008
16763565Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells.EMBO J2006
17186704Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour.Syst Biol (Stevenage)2006
17060902Physicochemical modelling of cell signalling pathways.Nat Cell Biol2006
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Collaborators

Peter K Sorger
Co-authored papers 6
Douglas A Lauffenburger
Massachusetts Institute of Technology
Co-authored papers 5
Jennifer M Hayashi
Gladstone Institutes
Co-authored papers 2
Artem Sokolov
Harvard Medical School
Co-authored papers 2
Kim Lewis
Co-authored papers 2
David R Sherman
University of Washington
Co-authored papers 1
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Center for Emerging and Re-emerging Infectious Diseases, University of Washington
Co-authored papers 1
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Co-authored papers 1
Scott A Shaffer
Co-authored papers 1
Kevin A Janes
University of Virginia
Co-authored papers 1
David L Kaplan
Co-authored papers 1
Case W McNamara
a division of The Scripps Research Institute La Jolla
Co-authored papers 1
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Institute for Systems Biology
Co-authored papers 1
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Claire L Carter
Co-authored papers 1
Shirit Einav
Stanford University School of Medicine
Co-authored papers 1
Jeremy L Muhlich
Co-authored papers 1
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The Rockefeller University
Co-authored papers 1
Jason H Yang
Rutgers New Jersey Medical School
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Co-authored papers 1
Christina E Baer
Co-authored papers 1
Ronald N Germain
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Co-authored papers 1
Benjamin F Cravatt
Scripps Research Institute
Co-authored papers 1
Anna Kuchina
University of Washington
Co-authored papers 1
Jason A Papin
University of Virginia
Co-authored papers 1
Julio Saez-Rodriguez
Institute of Computational Biomedicine, Heidelberg University
Co-authored papers 1
Sriram Chandrasekaran
University of Michigan ann arbor
Co-authored papers 1
Frederick S Buckner
University of Washington
Co-authored papers 1
John P Overington
Institute of Cardiovascular Science, University College London
Co-authored papers 1
Tom Alber
University of California berkeley
Co-authored papers 1
Release 1.2