Author details

Full Name

Lambertus Klei

Affiliation

ORCID

Career Start Year

2005

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37100590	Direct additive genetics and maternal effect contribute to the risk of Tourette disorder.	J Neurol Neurosurg Psychiatry	2023
37986747	Comparison of gene expression in living and postmortem human brain.	medRxiv	2023
37790341	Evaluating and Improving Health Equity and Fairness of Polygenic Scores.		2023
37773317	Heritable Composite Phenotypes Defined by Combinations of Conduct Problem, Depression, and Temperament Features: Contributions to risk for Alcohol Problems.		2023
34789012	The Genetic Architecture of Obsessive-Compulsive Disorder: Contribution of Liability to OCD From Alleles Across the Frequency Spectrum.	Am J Psychiatry	2022
35987687	Schizophrenia-associated differential DNA methylation in brain is distributed across the genome and annotated to MAD1L1, a locus at which DNA methylation and transcription phenotypes share genetic variation with schizophrenia risk.	Transl Psychiatry	2022
35982160	Rare coding variation provides insight into the genetic architecture and phenotypic context of autism.	Nat Genet	2022
34615521	How rare and common risk variation jointly affect liability for autism spectrum disorder.	Mol Autism	2021
34112972	Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease.	Mol Psychiatry	2021
33723209	Transcriptome alterations are enriched for synapse-associated genes in the striatum of subjects with obsessive-compulsive disorder.	Transl Psychiatry	2021
34615535	Prevalence and phenotypic impact of rare potentially damaging variants in autism spectrum disorder.	Mol Autism	2021
30862939	Correction: Genetic risk for schizophrenia and psychosis in Alzheimer disease.	Mol Psychiatry	2020
32268104	Whole-Genome and RNA Sequencing Reveal Variation and Transcriptomic Coordination in the Developing Human Prefrontal Cortex.	Cell Rep	2020
32199606	Maternal Effects as Causes of Risk for Obsessive-Compulsive Disorder.	Biol Psychiatry	2020
31907560	Cohort profile: Epidemiology and Genetics of Obsessive-compulsive disorder and chronic tic disorders in Sweden (EGOS).	Soc Psychiatry Psychiatr Epidemiol	2020
31928911	Age dependent association of inbreeding with risk for schizophrenia in Egypt.	Schizophrenia Research	2020
32652852	Functional connectome fingerprinting accuracy in youths and adults is similar when examined on the same day and 1.5-years apart.	Human Brain Mapping	2020
30587579	Semisoft clustering of single-cell data.	Proceedings of the National Academy of Sciences of the United States of America	2019
29700473	An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder.	Nat Genet	2018
28461698	Genetic risk for schizophrenia and psychosis in Alzheimer disease.	Mol Psychiatry	2018
29892012	An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.	Nat Genet	2018
30545852	Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder.	Science	2018
29100626	Heritable Variation, With Little or No Maternal Effect, Accounts for Recurrence Risk to Autism Spectrum Disorder in Sweden.	Biol Psychiatry	2018
29306175	Joint evaluation of serum C-Reactive Protein levels and polygenic risk scores as risk factors for schizophrenia.	Psychiatry Research	2018
28277564	Analysis of Shared Haplotypes amongst Palauans Maps Loci for Psychotic Disorders to 4q28 and 5q23-q31.	Mol Neuropsychiatry	2017
28570395	Runs of homozygosity, copy number variation, and risk for depression and suicidal behavior in an Arab Bedouin kindred.	Psychiatr Genet	2017
27492617	A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition.	Gastroenterology	2016
27668389	Gene expression elucidates functional impact of polygenic risk for schizophrenia.	Nat Neurosci	2016
26402605	Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci.	Neuron	2015
25752243	The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment.	Nat Commun	2015
25534755	A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity?	Biol Psychiatry	2015
24602502	DAWN: a framework to identify autism genes and subnetworks using gene expression and genetics.	Mol Autism	2014
25363760	Synaptic, transcriptional and chromatin genes disrupted in autism.	Nature	2014
24821083	Modest impact on risk for autism spectrum disorder of rare copy number variants at 15q11.2, specifically breakpoints 1 to 2.	Autism Res	2014
25038753	Most genetic risk for autism resides with common variation.	Nat Genet	2014
24860643	Rare deleterious mutations of the gene EFR3A in autism spectrum disorders.	Mol Autism	2014
24768552	Convergence of genes and cellular pathways dysregulated in autism spectrum disorders.	Am J Hum Genet	2014
24906019	Transcriptional consequences of 16p11.2 deletion and duplication in mouse cortex and multiplex autism families.	American Journal of Human Genetics	2014
24980794	Characterizing runs of homozygosity and their impact on risk for psychosis in a population isolate.	Am J Med Genet B Neuropsychiatr Genet	2014
22234486	Principal components of heritability from neurocognitive domains differ between families with schizophrenia and control subjects.	Schizophr Bull	2013
22975221	Persistent infection with neurotropic herpes viruses and cognitive impairment.	Psychol Med	2013
24267886	Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism.	Cell	2013
23933821	Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.	Nat Genet	2013
23746936	Adjusting head circumference for covariates in autism: clinical correlates of a highly heritable continuous trait.	Biol Psychiatry	2013
24587841	REFINING GENETICALLY INFERRED RELATIONSHIPS USING TREELET COVARIANCE SMOOTHING.	Annals of Applied Statistics	2013
22170232	Amino acid position 11 of HLA-DRÎ²1 is a major determinant of chromosome 6p association with ulcerative colitis.	Genes Immun	2012
22652028	Vitamin D insufficiency and severe asthma exacerbations in Puerto Rican children.	Am J Respir Crit Care Med	2012
22966150	Evaluation of HLA polymorphisms in relation to schizophrenia risk and infectious exposure.	Schizophr Bull	2012
22843504	Individual common variants exert weak effects on the risk for autism spectrum disorders.	Hum Mol Genet	2012
22726847	Genome-wide transcriptome profiling reveals the functional impact of rare de novo and recurrent CNVs in autism spectrum disorders.	Am J Hum Genet	2012