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Author Details

Brian R Hearn
Department of Pharmaceutical Chemistry and, University of California san francisco
2002
22
13
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
33822591Attenuation of the Reaction of Michael Acceptors with Biologically Important Nucleophiles.Bioconjug Chem2021
32302100Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine.ACS Chem Biol2020
31744896PET Imaging of the EPR Effect in Tumor Xenografts Using Small 15 nm Diameter Polyethylene Glycols Labeled with Zirconium-89.Mol Cancer Ther2020
29249604Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation.Structure2018
29577950Primary deuterium kinetic isotope effects prolong drug release and polymer biodegradation in a drug delivery system.J Control Release2018
27149244Surgical sealants with tunable swelling, burst pressures, and biodegradation rates.J Biomed Mater Res B Appl Biomater2017
29045385USP7 small-molecule inhibitors interfere with ubiquitin binding.Nature2017
28605180A Hydrogel-Microsphere Drug Delivery System That Supports Once-Monthly Administration of a GLP-1 Receptor Agonist.ACS Chem Biol2017
26789650Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response.ChemMedChem2016
27657443Approach for Half-Life Extension of Small Antibody Fragments That Does Not Affect Tissue Uptake.Bioconjug Chem2016
27435960Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch.Elife2016
25584814Biodegradable tetra-PEG hydrogels as carriers for a releasable drug delivery system.Bioconjug Chem2015
25875391Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.Elife2015
24259468Tailoring small molecules for an allosteric site on procaspase-6.ChemMedChem2014
24977643Broad-spectrum allosteric inhibition of herpesvirus proteases.Biochemistry2014
23741617Pharmacological brake-release of mRNA translation enhances cognitive memory.Elife2013
22394492Predicting and improving the membrane permeability of peptidic small molecules.J Med Chem2012
23227217Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6.PLoS One2012
17691074Semisynthesis and cytotoxicity of hypothemycin analogues.ChemMedChem2007
16441089Methanolysis products of disorazole A1.J Nat Prod2006
16805551C-15 thiazol-4-yl analogues of (E)-9,10-didehydroepothilone D: synthesis and cytotoxicity.Org Lett2006
12182597A divergent approach to the myriaporones and tedanolide: completion of the carbon skeleton of myriaporone 1.Org Lett2002
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Collaborators

Adam R Renslo
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 10
Priyadarshini Jaishankar
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 8
Peter Walter
University of California san francisco
Co-authored papers 4
Punitha Vedantham
Department of Pharmaceutical Chemistry and, University of California san francisco
Co-authored papers 4
Carmela Sidrauski
Calico Life Sciences LLC
Co-authored papers 3
Jordan C Tsai
University of California san francisco
Co-authored papers 2
Jonathan E Gable
Novartis Institute for Tropical Diseases
Co-authored papers 1
Edward L Tang
Co-authored papers 1
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Jeffrey R Johnson
Gladstone Institutes
Co-authored papers 1
Erik Verschueren
University of California San Francisco
Co-authored papers 1
Christopher S Fraser
College of Biological Sciences, University of California davis
Co-authored papers 1
Matthew P Jacobson
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 1
Charles S Craik
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 1
Aaron S Mendez
University of California Berkeley
Co-authored papers 1
Dario R Alessi
University of Dundee
Co-authored papers 1
Masaaki Sokabe
College of Biological Sciences, University of California davis
Co-authored papers 1
Jonathan S Weissman
Whitehead Institute for Biomedical Research
Co-authored papers 1
Martin Kampmann
Institute for Neurodegenerative Diseases, University of California san francisco
Co-authored papers 1
Billy W Newton
University of California San Francisco
Co-authored papers 1
Release 1.2