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Author Details

Claus Nerlov
MRC Weatherall Institute of Molecular Medicine, University of Oxford
1990
106
52
PMIDPaper TitleJournal TitlePublished Year
37127714Epigenetic programming defines haematopoietic stem cell fate restriction.Nat Cell Biol2023
37562000Loss of endothelial membrane KIT ligand affects systemic KIT ligand levels but not bone marrow hematopoietic stem cells.Blood2023
37770432Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner.Nat Commun2023
37370129Panhematopoietic RNA barcoding enables kinetic measurements of nucleate and anucleate lineages and the activation of myeloid clones following acute platelet depletion.Genome Biol2023
34903641DNMT1 Deficiency Impacts on Plasmacytoid Dendritic Cells in Homeostasis and Autoimmune Disease.J Immunol2022
35710794Author Correction: Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia.Nat Commun2022
35848459Endothelial cell death after ionizing radiation does not impair vascular structure in mouse tumor models.EMBO Rep2022
33600869To bi or not to bi: Acute erythroid leukemias and hematopoietic lineage choice.Exp Hematol2021
32330454C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor.Cancer Cell2020
31863798CD34 and EPCR coordinately enrich functional murine hematopoietic stem cells under normal and inflammatory conditions.Exp Hematol2020
31721195Liver haploinsufficiency of RuvBL1 causes hepatic insulin resistance and enhances hepatocellular carcinoma progression.Int J Cancer2020
32796847Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing.Nat Commun2020
30301719Inflammatory signals directly instruct PU.1 in HSCs via TNF.Blood2019
31784538Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia.Nat Commun2019
31697810Single-cell analysis of bone marrow-derived CD34+ cells from children with sickle cell disease and thalassemia.Blood2019
31662298Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia.Cancer Discov2019
31303548Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging.Cell Stem Cell2019
31126997Identification of two distinct pathways of human myelopoiesis.Sci Immunol2019
30975913Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation.Haematologica2019
30877232Dependence on Myb expression is attenuated in myeloid leukaemia with N-terminal CEBPA mutations.Life Sci Alliance2019
30679799CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex.Leukemia2019
30602765Haematopoiesis in the era of advanced single-cell technologies.Nat Cell Biol2019
29339402Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis.Blood2018
30166337Kit ligand has a critical role in mouse yolk sac and aorta-gonad-mesonephros hematopoiesis.EMBO Rep2018
29986855Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin.Blood Adv2018
30596405Direct role of FLT3 in regulation of early lymphoid progenitors.Br J Haematol2018
30393781Multiple membrane extrusion sites drive megakaryocyte migration into bone marrow blood vessels.Life Sci Alliance2018
30410062Bi-directional signaling by membrane-bound KitL induces proliferation and coordinates thymic endothelial cell and thymocyte expansion.Nat Commun2018
29456137Lineage-Biased Hematopoietic Stem Cells Are Regulated by Distinct Niches.Dev Cell2018
29298288Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells.Nature2018
27746211Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis.Biochim Biophys Acta Gen Subj2017
28461596A transit-amplifying population underpins the efficient regenerative capacity of the testis.J Exp Med2017
28939758Wnt/β-Catenin Signaling Induces Integrin α4β1 in T Cells and Promotes a Progressive Neuroinflammatory Disease in Mice.J Immunol2017
28637883Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation.J Exp Med2017
27111842Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.Nat Cell Biol2016
27695000Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors.Nat Immunol2016
27494670Hematopoietic Lineage Diversification, Simplified.Cell Stem Cell2016
27411635Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios.Nature2016
26780297A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors.Nat Cell Biol2016
27043410Distinct myeloid progenitor-differentiation pathways identified through single-cell RNA sequencing.Nat Immunol2016
27009448Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells.Nat Commun2016
26167872Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.Nat Chem Biol2015
26379026Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.Nat Chem Biol2015
26162409Disease evolution and outcomes in familial AML with germline CEBPA mutations.Blood2015
24493804Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate.J Exp Med2014
24835589Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.Cancer Cell2014
23727242FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors.Cell Rep2013
23934107Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy.Nature2013
23801632β-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL.Blood2013
22068055FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors.EMBO J2012
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Collaborators

Roy Drissen
MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital
Co-authored papers 9
Iain C Macaulay
Co-authored papers 8
Cristina Di Genua
MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital
Co-authored papers 7
Robert M??nsson
Karolinska Institutet
Co-authored papers 4
Mikael Sigvardsson
Lund University, Linkoping University. .
Co-authored papers 2
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University of Texas at Austin
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Theodore P Braun
Oregon Health & Science University
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Sophia Jeng
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 2
Rhonda E Ries
Clinical Research Division, Fred Hutchinson Cancer Research Center
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Daniel G Tenen
Harvard Stem Cell Institute, Harvard Medical School
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Zachary Schonrock
Knight Cancer Institute, Oregon Health & Science University
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Sarah A Carratt
Knight Cancer Institute, Oregon Health & Science University
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Christoph Bock
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
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Kimberly A Nevonen
Knight Cardiovascular Institute, Oregon Health and Science University
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Kevin Watanabe-Smith
Knight Cancer Institute, Oregon Health & Science University
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Lucia Carbone
Knight Cardiovascular Institute, Oregon Health and Science University
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Richard Marcellus
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 2
Dalia Barsyte-Lovejoy
University of Toronto, College St
Co-authored papers 2
Julia E Maxson
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 2
Andreas Sch??negger
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Co-authored papers 2
Michal R Grzadkowski
Oregon Health & Science University
Co-authored papers 2
Shannon K McWeeney
Oregon Health & Science University, University of California Berkeley
Co-authored papers 2
Dorian LaTocha
Knight Cancer Institute, Oregon Health & Science University
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Soheil Meshinchi
Fred Hutchinson Cancer Research Centre
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Rima Al-Awar
Ontario Institute for Cancer Research, University Avenue
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Joseph Estabrook
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Miguel A Andrade-Navarro
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Release 1.2