Author details

Full Name

Paul J Tesar

Affiliation

ORCID

Career Start Year

2005

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36798415	Pervasive environmental chemicals impair oligodendrocyte development.		2023
37577713	Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis.		2023
37333182	Enteric glial hub cells coordinate intestinal motility.		2023
35128409	Inhibition of SC4MOL and HSD17B7 shifts cellular sterol composition and promotes oligodendrocyte formation.	RSC Chemical Biology	2022
36008413	Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay.	Nature Communications	2022
33091368	Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function.		2021
34153742	Oligodendrocyte progenitor cell fate and function in development and disease.	Current Opinion in Cell Biology	2021
32610343	Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease.	Nature	2020
32246942	Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS.	Cell	2020
32570796	Pathogenic Prion Protein Isoforms Are Not Present in Cerebral Organoids Generated from Asymptomatic Donors Carrying the E200K Mutation Associated with Familial Prion Disease.	Pathogens	2020
31242417	Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling.	Cell Rep	2019
31644912	Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination.	Cell Reports	2019
31215271	Developing therapeutic strategies to promote myelin repair in multiple sclerosis.	Expert Review of Neurotherapeutics	2019
30773481	Diverse Chemical Scaffolds Enhance Oligodendrocyte Formation by Inhibiting CYP51, TM7SF2, or EBP.	Cell Chemical Biology	2019
31440130	The Chromatin Environment Around Interneuron Genes in Oligodendrocyte Precursor Cells and Their Potential for Interneuron Reprograming.	Frontiers in Neuroscience	2019
29771306	Drug screening for human genetic diseases using iPSC models.	Human Molecular Genetics	2018
28602122	Transcriptome-Wide Analyses of Human Neonatal Articular Cartilage and Human Mesenchymal Stem Cell-Derived Cartilage Provide a New Molecular Target for Evaluating Engineered Cartilage.	Tissue Engineering - Part A.	2018
30306660	NG2 expression in NG2 glia is regulated by binding of SoxE and bHLH transcription factors to a Cspg4 intronic enhancer.	GLIA	2018
30213958	Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells.	Nature Communications	2018
30146490	Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease.	Stem Cell Reports	2018
30046109	Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination.	Nature	2018
30046099	Induction of myelinating oligodendrocytes in human cortical spheroids.	Nature Methods	2018
29431731	Physiological genomics identifies genetic modifiers of long QT syndrome type 2 severity.	J Clin Invest	2018
27882623	Concise Review: Stem Cell-Based Treatment of Pelizaeus-Merzbacher Disease.	Stem Cells	2017
28736215	Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia.	Cell Stem Cell	2017
28678782	Transcription elongation factors represent in vivo cancer dependencies in glioblastoma.	Nature	2017
28366443	Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes.	Am J Hum Genet	2017
29029894	Clemastine fumarate for promotion of optic nerve remyelination.	Lancet, The	2017
29220662	iPSC Reprogramming Is Not Just an Open and Shut Case.	Cell Stem Cell	2017
27547496	Using iPSC-derived human DA neurons from opioid-dependent subjects to study dopamine dynamics.	Brain and Behavior	2016
26833092	Snapshots of Pluripotency.	Stem Cell Reports	2016
27035534	Lower Dopamine D2 Receptor Expression Levels in Human Dopaminergic Neurons Derived From Opioid-Dependent iPSCs.	American Journal of Psychiatry	2016
26631080	Depletion of Olig2 in oligodendrocyte progenitor cells infected by Theiler's murine encephalomyelitis virus.	Journal of NeuroVirology	2016
26461092	Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells.	Cancer Cell	2015
25896324	Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.	Nature	2015
24623855	Derivation of naive human embryonic stem cells.	Proc Natl Acad Sci U S A	2014
25493560	Lgr5 Marks Post-Mitotic, Lineage Restricted Cerebellar Granule Neurons during Postnatal Development.	PLoS One	2014
24905169	Epigenomic comparison reveals activation of "seed" enhancers during transition from naive to primed pluripotency.	Cell Stem Cell	2014
24529709	NPTX1 regulates neural lineage specification from human pluripotent stem cells.	Cell Reports	2014
23117585	StemCellDB: the human pluripotent stem cell database at the National Institutes of Health.	Stem Cell Research	2013
23773267	Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis.	BMC Genetics	2013
23975801	Generation and characterization of epiblast stem cells from blastocyst-stage mouse embryos.	Methods in Molecular Biology	2013
24129572	Retinal pigmented epithelial cells obtained from human induced pluripotent stem cells possess functional visual cycle enzymes in vitro and in vivo.	J Biol Chem	2013
23584611	Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells.	Nature Biotechnology	2013
23169579	Transcription elongation factor Tcea3 regulates the pluripotent differentiation potential of mouse embryonic stem cells via the Lefty1-Nodal-Smad2 pathway.	Stem Cells	2013
22138358	Direct and indirect contribution of human embryonic stem cell-derived hepatocyte-like cells to liver repair in mice.	Gastroenterology	2012
22923694	Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability.	Proceedings of the National Academy of Sciences of the United States of America	2012
22499810	Epigenomic enhancer profiling defines a signature of colon cancer.	Science	2012
22463982	Accessing naÃ¯ve human pluripotency.	Curr Opin Genet Dev	2012
22822199	DNA and chromatin modification networks distinguish stem cell pluripotent ground states.	Mol Cell Proteomics	2012