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Author Details

Stanley B Prusiner
Weill Institute for Neurosciences, University of California San Francisco
1965
585
152
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36399277Aβ and Tau Prions Causing Alzheimer's Disease.Methods Mol Biol2023
37236970Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments.Nat Commun2023
35115402Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy.Proc Natl Acad Sci U S A2022
36276634Trans-channel fluorescence learning improves high-content screening for Alzheimer's disease therapeutics.Nat Mach Intell2022
36018376Multiple system atrophy prions transmit neurological disease to mice expressing wild-type human α-synuclein.Acta Neuropathol2022
36343257Aβ and tau prions feature in the neuropathogenesis of Down syndrome.Proc Natl Acad Sci U S A2022
34064393How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer's Disease and Other Neurodegenerative Disorders.Int J Mol Sci2021
33848474Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components.Neuron2021
33869960Silver Benzoate Facilitates the Copper-Catalyzed C-N Coupling of Iodoazoles with Aromatic Nitrogen Heterocycles.ACS Omega2021
33929208Water-Soluble Iridium Photoredox Catalyst for the Trifluoromethylation of Biomolecule Substrates in Phosphate Buffered Saline Solvent.Org Lett2021
32123368Prion protein - mediator of toxicity in multiple proteinopathies.Nat Rev Neurol2020
32017806Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy.PLoS Pathog2020
32071678Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity.ACS Med Chem Lett2020
32803268Expanding spectrum of prion diseases.Emerg Top Life Sci2020
32949533Prion biology: implications for Alzheimer's disease therapeutics.Lancet Neurol2020
30690664Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines.Acta Neuropathol2019
31109379Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein.Acta Neuropathol Commun2019
28849371MSA prions exhibit remarkable stability and resistance to inactivation.Acta Neuropathol2018
29950625Citations must default to the online publication date.Nature2018
28193770β-Amyloid Prions and the Pathobiology of Alzheimer's Disease.Cold Spring Harb Perspect Med2018
28213437α-Synuclein: Multiple System Atrophy Prions.Cold Spring Harb Perspect Med2018
29311311Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease.Proc Natl Acad Sci U S A2018
29279394Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.Proc Natl Acad Sci U S A2018
29319162A long-lived Aβ oligomer resistant to fibrillization.Biopolymers2018
28837163A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells.Nat Chem2017
28246183Bioassays and Inactivation of Prions.Cold Spring Harb Perspect Biol2017
28096244Experimental Models of Inherited PrP Prion Diseases.Cold Spring Harb Perspect Med2017
28096242Developing Therapeutics for PrP Prion Diseases.Cold Spring Harb Perspect Med2017
29157304A novel vector for transgenesis in the rat CNS.Acta Neuropathol Commun2017
29059326Kinetics of Human Mutant Tau Prion Formation in the Brains of 2 Transgenic Mouse Lines.JAMA Neurol2017
29203673Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice.Proc Natl Acad Sci U S A2017
27402759FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice.Proc Natl Acad Sci U S A2016
27911827Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells.Proc Natl Acad Sci U S A2016
27414264Structural Polymorphism of Alzheimer's β-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study.J Am Chem Soc2016
27350609Towards authentic transgenic mouse models of heritable PrP prion diseases.Acta Neuropathol2016
27440899Guinea Pig Prion Protein Supports Rapid Propagation of Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease Prions.J Virol2016
27317802Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice.J Pharmacol Exp Ther2016
25809267Structural studies of truncated forms of the prion protein PrP.Biophys J2015
26324905Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.Proc Natl Acad Sci U S A2015
26287631Prion Protein-Antibody Complexes Characterized by Chromatography-Coupled Small-Angle X-Ray Scattering.Biophys J2015
26286986Propagation of prions causing synucleinopathies in cultured cells.Proc Natl Acad Sci U S A2015
26094969Modulation of Creutzfeldt-Jakob disease prion propagation by the A224V mutation.Ann Neurol2015
26224882Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains.J Pharmacol Exp Ther2015
26116725Use of a 2-aminothiazole to Treat Chronic Wasting Disease in Transgenic Mice.J Infect Dis2015
25695325Mechanism of scrapie prion precipitation with phosphotungstate anions.ACS Chem Biol2015
24699458Evidence that bank vole PrP is a universal acceptor for prions.PLoS Pathog2014
24982139Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients.Proc Natl Acad Sci U S A2014
24982137Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice.Proc Natl Acad Sci U S A2014
24860095Mouse models for studying the formation and propagation of prions.J Biol Chem2014
24530226Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells.Bioorg Med Chem2014
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