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Author Details

Douglas A Melton
Harvard University, Howard Hughes Medical Institute, Harvard Stem Cell Institute
1977
250
121
PMIDPaper TitleJournal TitlePublished Year
36599351Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance.Cell Rep Med2023
37028408Matters arising: Insufficient evidence that pancreatic β cells are derived from adult ductal Neurog3-expressing progenitors.Cell Stem Cell2023
34995481Cell maturation: Hallmarks, triggers, and manipulation.Cell2022
36055241Whole-genome CRISPR screening identifies genetic manipulations to reduce immune rejection of stem cell-derived islets.Stem Cell Reports2022
35245439Genetic manipulation of stress pathways can protect stem-cell-derived islets from apoptosis in vitro.Stem Cell Reports2022
32122884A Stem Cell Approach to Cure Type 1 Diabetes.Cold Spring Harb Perspect Biol2021
34741877A human ESC line for efficient CRISPR editing of pluripotent stem cells.Stem Cell Res2021
34504013A therapeutic convection-enhanced macroencapsulation device for enhancing β cell viability and insulin secretion.Proc Natl Acad Sci U S A2021
34088000Generation of a heterozygous GAPDH-Luciferase human ESC line (HVRDe008-A-1) for in vivo monitoring of stem cells and their differentiated progeny.Stem Cell Res2021
33454830The promise of stem cell-derived islet replacement therapy.Diabetologia2021
33472944Building Biomimetic Potency Tests for Islet Transplantation.Diabetes2021
32375022A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion.Cell Metab2020
31934849<i>Midkine</i> is a dual regulator of wound epidermis development and inflammation during the initiation of limb regeneration.Elife2020
31839570Circadian Entrainment Triggers Maturation of Human In Vitro Islets.Cell Stem Cell2020
31928884Identification of a LIF-Responsive, Replication-Competent Subpopulation of Human β Cells.Cell Metab2020
31707831Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells via p53-Induced Quiescence.Circulation2020
33208361A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells.Sci Adv2020
32719542Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes.Nat Metab2020
32668238Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells.Cell Rep2020
32521122Purification of Live Stem-Cell-Derived Islet Lineage Intermediates.Curr Protoc Stem Cell Biol2020
32382023A method for the generation of human stem cell-derived alpha cells.Nat Commun2020
32165710Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice.Sci Rep2020
32402282Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis.Cell Rep2020
30661759A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets.Cell2019
31756031Live Cell Monitoring and Enrichment of Stem Cell-Derived β Cells Using Intracellular Zinc Content as a Population Marker.Curr Protoc Stem Cell Biol2019
31464325Synchronized stimulation and continuous insulin sensing in a microfluidic human Islet on a Chip designed for scalable manufacturing.Lab Chip2019
31282856Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq.Elife2019
30778231Regenerating the field of cardiovascular cell therapy.Nat Biotechnol2019
31068696Charting cellular identity during human in vitro β-cell differentiation.Nature2019
31040209Generation of hypoimmunogenic human pluripotent stem cells.Proc Natl Acad Sci U S A2019
31116975Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development.Cell Rep2019
30931946YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells.Nat Commun2019
30748094Alginate-microencapsulation of human stem cell-derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression.Am J Transplant2019
30602532Blastemal progenitors modulate immune signaling during early limb regeneration.Development2019
29599125Establishment of human pluripotent stem cell-derived pancreatic β-like cells in the mouse pancreas.Proc Natl Acad Sci U S A2018
29925956Author Correction: Pancreas regeneration.Nature2018
30303984Apolipoprotein E is a pancreatic extracellular factor that maintains mature β-cell gene expression.PLoS One2018
29781950Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells.Transplantation2018
29769672Pancreas regeneration.Nature2018
28038792Retraction Notice to: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation.Cell2017
26969972Applied Developmental Biology: Making Human Pancreatic Beta Cells for Diabetics.Curr Top Dev Biol2016
27667365A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure.Cell Syst2016
27410263Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy.PLoS One2016
27163171Generation of stem cell-derived β-cells from patients with type 1 diabetes.Nat Commun2016
27487970Corrigendum: Generation of stem cell-derived β-cells from patients with type 1 diabetes.Nat Commun2016
26808346Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.Nat Med2016
26908146Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation.Cell Stem Cell2016
27050590Corrigendum: Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.Nat Med2016
25815980Modeling human nutrition using human embryonic stem cells.Cell2015
26621734Angptl4 links α-cell proliferation following glucagon receptor inhibition with adipose tissue triglyceride metabolism.Proc Natl Acad Sci U S A2015
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Collaborators

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the Rockefeller University
Co-authored papers 10
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Stanford University School of Medicine
Co-authored papers 7
Yuval Dor
Hadassah-Hebrew University Medical Center
Co-authored papers 7
Kevin Eggan
Co-authored papers 6
Dieter Egli
Co-authored papers 4
Danwei Huangfu
Co-authored papers 4
Jose Oberholzer
University of Virginia Health System
Co-authored papers 3
Robert Langer
Co-authored papers 3
Daniel G Anderson
Co-authored papers 3
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Broad Institute
Co-authored papers 2
Tom Maniatis
College des medecins du Quebec
Co-authored papers 2
Kristen J Brennand
Co-authored papers 2
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The Francis Crick Institute
Co-authored papers 2
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University of California Los Angeles
Co-authored papers 2
Michael R Green
Co-authored papers 2
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Harvard University
Co-authored papers 2
Bridget K Wagner
Co-authored papers 2
Miguel Ramalho-Santos
University of Toronto
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Co-authored papers 2
David M Sabatini
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
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Charles D Stiles
Co-authored papers 1
Joan Mazzarelli
Center for Bioinformatics, University of Pennsylvania
Co-authored papers 1
Michael G Roper
Florida State University
Co-authored papers 1
Amy J Wagers
Joslin Diabetes Center
Co-authored papers 1
Nabeel Bardeesy
Massachusetts General Hospital
Co-authored papers 1
Bingbing Yuan
Whitehead Institute for Biomedical Research
Co-authored papers 1
Christopher V E Wright
Vanderbilt University
Co-authored papers 1
Renaud Gaujoux
Co-authored papers 1
Sandra W Clifton
Garvan Institute of Medical Research
Co-authored papers 1
Karlyne M Reilly
Center for Cancer Research, National Cancer Institute
Co-authored papers 1
Release 1.2