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Author Details

Xi Huang
The Hospital for Sick Children
2005
44
20
Antoine Forget (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36323321Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity.Neuron2023
37697045A designer peptide against the EAG2-Kvβ2 potassium channel targets the interaction of cancer cells and neurons to treat glioblastoma.Nat Cancer2023
37639585Indentation induces instantaneous nuclear stiffening and unfolding of nuclear envelope wrinkles.Proc Natl Acad Sci U S A2023
36989359Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes.Sci Adv2023
36739447Conductive and elastic bottlebrush elastomers for ultrasoft electronics.Nat Commun2023
36893018Ultrathin and Flexible Bioelectronic Arrays for Functional Measurement of iPSC-Cardiomyocytes under Cardiotropic Drug Administration and Controlled Microenvironments.Nano Lett2023
32894333Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk.Rev Physiol Biochem Pharmacol2022
35857830Microrobotic swarms for selective embolization.Sci Adv2022
35786860Microrobotic Swarms for Intracellular Measurement with Enhanced Signal-to-Noise Ratio.ACS Nano2022
35521558Alterations in 3D chromatin organization contribute to tumorigenesis of <i>EGFR</i>-amplified glioblastoma.Comput Struct Biotechnol J2022
36551554Platinum-Resistant Ovarian Cancer Is Vulnerable to the cJUN-XRCC4 Pathway Inhibition.Cancers (Basel)2022
36446943Author Correction: Failure of human rhombic lip differentiation underlies medulloblastoma formation.Nature2022
36524349Correction: PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma.Cancer Res2022
36131014Failure of human rhombic lip differentiation underlies medulloblastoma formation.Nature2022
33378446Modeling human brain tumors in flies, worms, and zebrafish: From proof of principle to novel therapeutic targets.Neuro Oncol2021
33789112The DEAD-box helicase DDX56 is a conserved stemness regulator in normal and cancer stem cells.Cell Rep2021
33752907Channeling Force in the Brain: Mechanosensitive Ion Channels Choreograph Mechanics and Malignancies.Trends Pharmacol Sci2021
33859429Irx3 and Irx5 in Ins2-Cre<sup>+</sup> cells regulate hypothalamic postnatal neurogenesis and leptin response.Nat Metab2021
34705510Ectopic expression of <i>Irx3</i> and <i>Irx5</i> in the paraventricular nucleus of the hypothalamus contributes to defects in <i>Sim1</i> haploinsufficiency.Sci Adv2021
34266663Quantitative selection of single human sperm with high DNA integrity for intracytoplasmic sperm injection.Fertil Steril2021
32097463Chloride intracellular channel 1 cooperates with potassium channel EAG2 to promote medulloblastoma growth.J Exp Med2020
31664194Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma.Nature2019
31753914Paralytic, the <i>Drosophila</i> voltage-gated sodium channel, regulates proliferation of neural progenitors.Genes Dev2019
30344046A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression.Neuron2018
28712938ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells.Cell Stem Cell2017
28886368ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells.Cell Stem Cell2017
26760213Divergent clonal selection dominates medulloblastoma at recurrence.Nature2016
27325644PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma.Cancer Res2016
25961792Regulation of axon regeneration by the RNA repair and splicing pathway.Nat Neurosci2015
26258683EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.Nat Neurosci2015
25049269Targeting potassium channels in cancer.J Cell Biol2014
25401693Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma.Nat Med2014
22539980Widespread contribution of Gdf7 lineage to cerebellar cell types and implications for hedgehog-driven medulloblastoma formation.PLoS One2012
22855790Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.Genes Dev2012
20400693Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development.Proc Natl Acad Sci U S A2010
20834221Isolation, enrichment, and maintenance of medulloblastoma stem cells.J Vis Exp2010
20972404Intracranial orthotopic allografting of medulloblastoma cells in immunocompromised mice.J Vis Exp2010
19570847Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus.Development2009
19433083Shh and Gli3 activities are required for timely generation of motor neuron progenitors.Dev Biol2009
18429041Ventral specification and perturbed boundary formation in the mouse midbrain in the absence of Hedgehog signaling.Dev Dyn2008
18816854Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development.Dev Dyn2008
17468181Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for human holoprosencephaly.Hum Mol Genet2007
17507410Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord.Development2007
15880651Specific requirements of sonic hedgehog signaling during oligodendrocyte development.Dev Dyn2005
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Collaborators

Michael D Taylor
The Hospital for Sick Children
Co-authored papers 10
Peter B Dirks
The Hospital for Sick Children, University of Toronto
Co-authored papers 9
Vijay Ramaswamy
Hospital for Sick Children
Co-authored papers 9
Siyi Wanggou
Co-authored papers 8
William A Weiss
University of California san francisco
Co-authored papers 6
Weifan Dong
The Hospital for Sick Children
Co-authored papers 6
Sachin A Kumar
University of Toronto
Co-authored papers 5
Xiaochong Wu
The Hospital for Sick Children
Co-authored papers 5
Livia Garzia
The Research Institute of the McGill University Health Centre, McGill University
Co-authored papers 5
Lily Yeh Jan
Co-authored papers 5
James T Rutka
Hospital for Sick Children
Co-authored papers 4
David Malkin
Hospital for Sick Children
Co-authored papers 4
Patryk Skowron
University of Toronto
Co-authored papers 4
Nada Jabado
McGill University Health Centre (MUHC), Montreal Children's Hospital (MCH)
Co-authored papers 4
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Charles G Eberhart
Wilmer Eye Institute, Johns Hopkins Medical Institutions
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Anca Sorana Morrissy
Cumming School of Medicine, University of Calgary
Co-authored papers 4
Marco A Marra
University of British Columbia
Co-authored papers 4
Maura Massimino
Fondazione IRCCS Istituto Nazionale dei Tumori
Co-authored papers 4
Maria Luisa Garr??
DOPO Clinic and Neuroncology Unit, IRCCS Istituto Giannina Gaslini (IGG)
Co-authored papers 4
Robert J Wechsler-Reya
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 4
Hamza Farooq
BioBox Analytics Inc.
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Stefan M Pfister
Hopp Children's Cancer Center Heidelberg (KiTZ)
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Seung-Ki Kim
Seoul National University Children's Hospital
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Florence M G Cavalli
Institut Curie, PSL Research University
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Toshihiro Kumabe
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Betty Luu
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Release 1.2