|
| 36928661 | Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers. | Nucleic Acids Res | 2023 |
| 37697435 | RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells. | Nucleic Acids Res | 2023 |
| 34196309 | Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis. | J Clin Invest | 2021 |
| 33529165 | RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors. | J Clin Invest | 2021 |
| 30222135 | Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis. | J Clin Invest | 2018 |
| 26876210 | Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation. | Oncogene | 2016 |
| 27558965 | RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation. | Nat Commun | 2016 |
| 24858046 | Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression. | Oncogene | 2015 |
| 25736236 | INPP4B overexpression is associated with poor clinical outcome and therapy resistance in acute myeloid leukemia. | Leukemia | 2015 |
| 23382699 | Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis. | PLoS Genet | 2013 |
| 24324146 | RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks. | Proc Natl Acad Sci U S A | 2013 |
| 23966173 | Pirh2: an E3 ligase with central roles in the regulation of cell cycle, DNA damage response, and differentiation. | Cell Cycle | 2013 |
| 23449389 | The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover. | Cell Death Differ | 2013 |
| 22343728 | Caspase-8 is essential for maintaining chromosomal stability and suppressing B-cell lymphomagenesis. | Blood | 2012 |
| 21552324 | Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome. | PLoS Genet | 2011 |
| 22006951 | Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim-/- mice. | J Cell Biol | 2011 |
| 22125490 | Role of Pirh2 in mediating the regulation of p53 and c-Myc. | PLoS Genet | 2011 |
| 21791603 | Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis. | Mol Cell Biol | 2011 |
| 21625617 | Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer. | PLoS Genet | 2011 |
| 20385750 | Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer. | J Exp Med | 2010 |
| 20696928 | Dysregulation of the mevalonate pathway promotes transformation. | Proc Natl Acad Sci U S A | 2010 |
| 19008920 | Essential role for Bclaf1 in lung development and immune system function. | Cell Death Differ | 2009 |
| 17213198 | Essential role for caspase-8 in Toll-like receptors and NFkappaB signaling. | J Biol Chem | 2007 |
| 17875692 | Functional interplay of p53 and Mus81 in DNA damage responses and cancer. | Cancer Res | 2007 |
| 16107613 | RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. | Genes Dev | 2005 |
| 15131084 | Collaboration of Brca1 and Chk2 in tumorigenesis. | Genes Dev | 2004 |
| 15343267 | Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity. | EMBO J | 2004 |
| 12654726 | Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. | Genes Dev | 2003 |
| 12970760 | Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity. | Nat Immunol | 2003 |
| 10881179 | Brca1 required for T cell lineage development but not TCR loci rearrangement. | Nat Immunol | 2000 |
| 10528193 | In vivo evidence that caspase-3 is required for Fas-mediated apoptosis of hepatocytes. | J Immunol | 1999 |
| 10075979 | The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis. | J Exp Med | 1999 |
| 9708736 | Differential requirement for caspase 9 in apoptotic pathways in vivo. | Cell | 1998 |
| 9512515 | Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. | Genes Dev | 1998 |
| 9753321 | Apaf1 is required for mitochondrial pathways of apoptosis and brain development. | Cell | 1998 |
| 9285409 | The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes. | Immunity | 1997 |
| 8598042 | Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice. | Cell | 1996 |
| 8674108 | The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. | Cell | 1996 |