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Author Details

Jay R Thiagarajah
Boston Children's Hospital, Harvard Medical School
2000
57
28
Emma Lundberg (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37741420Intermittent Feasting: Dampening Our Gut Immune Spirits.Gastroenterology2024
36662620Gasdermin D pore-forming activity is redox-sensitive.Cell Rep2023
37258747A Roadmap for the Human Gut Cell Atlas.Nat Rev Gastroenterol Hepatol2023
37131772WNT2B Deficiency Causes Increased Susceptibility to Colitis in Mice and Impairs Intestinal Epithelial Development in Humans.bioRxiv2023
36747680Therapy Development for Microvillus Inclusion Disease using Patient-derived Enteroids.bioRxiv2023
36608717The Immune Ghosts of Pandemics Past.Gastroenterology2023
36422736The genetics of monogenic intestinal epithelial disorders.Hum Genet2023
36243004Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection.Cell2022
35728684Disrupting Polarized Trafficking in Intestinal Epithelial Cells: Insights From a Novel Congenital Enteropathy Gene.Gastroenterology2022
35712665Membrane Lipids in Epithelial Polarity: Sorting out the PIPs.Front Cell Dev Biol2022
34289345Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway.Cell2021
36382063Minimally Invasive Image-Guided Gut Transport Function Measurement Probe.Front Phys2021
33674797Pycro-Manager: open-source software for customized and reproducible microscope control.Nat Methods2021
33526876Novel variants in the stem cell niche factor WNT2B define the disease phenotype as a congenital enteropathy with ocular dysgenesis.Eur J Hum Genet2021
33087577Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling.Proc Natl Acad Sci U S A2020
31985747IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress.J Cell Biol2020
31743734Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Disease Caused by TTC7A Deficiency.Gastroenterology2020
32064493NOX1 Regulates Collective and Planktonic Cell Migration: Insights From Patients With Pediatric-Onset IBD and NOX1 Deficiency.Inflamm Bowel Dis2020
30668547Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea.JCI Insight2019
30311684An Intravenous Fish Oil-Based Lipid Emulsion Successfully Treats Intractable Pruritus and Cholestasis in a Patient with Microvillous Inclusion Disease.Hepatology2019
29654747Advances in Evaluation of Chronic Diarrhea in Infants.Gastroenterology2018
29909964Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations.Am J Hum Genet2018
30355448INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling.Elife2018
28049834Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia.Proc Natl Acad Sci U S A2017
27669437The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion.Oncogene2017
26864627Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion.Mol Biol Cell2016
27127798CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation.Cell Mol Gastroenterol Hepatol2016
26122478Secretory diarrhoea: mechanisms and emerging therapies.Nat Rev Gastroenterol Hepatol2015
26157392Congenital chloride-losing diarrhea in a Mexican child with the novel homozygous SLC26A3 mutation G393W.Front Physiol2015
24052273Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice.Gut2014
24945437Altered goblet cell differentiation and surface mucus properties in Hirschsprung disease.PLoS One2014
24316107Discovery and development of antisecretory drugs for treating diarrheal diseases.Clin Gastroenterol Hepatol2014
23331030CFTR inhibitors.Curr Pharm Des2013
23898009Response to "Diffusion versus convection".J Gen Physiol2013
23992767Chloride channel-targeted therapy for secretory diarrheas.Curr Opin Pharmacol2013
23359285Convective washout reduces the antidiarrheal efficacy of enterocyte surface-targeted antisecretory drugs.J Gen Physiol2013
22850599CFTR inhibitors for treating diarrheal disease.Clin Pharmacol Ther2012
20581223Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea.FASEB J2010
20713545Airway surface liquid depth imaged by surface laser reflectance microscopy.J Gen Physiol2010
17573386Impaired enterocyte proliferation in aquaporin-3 deficiency in mouse models of colitis.Gut2007
16554832Slowed diffusion in tumors revealed by microfiberoptic epifluorescence photobleaching.Nat Methods2006
15765520Noninvasive early detection of brain edema in mice by near-infrared light scattering.J Neurosci Res2005
15808339New drug targets for cholera therapy.Trends Pharmacol Sci2005
15596485Submucosal gland dysfunction as a primary defect in cystic fibrosis.FASEB J2005
14762788Prevention of toxin-induced intestinal ion and fluid secretion by a small-molecule CFTR inhibitor.Gastroenterology2004
15001557A small molecule CFTR inhibitor produces cystic fibrosis-like submucosal gland fluid secretions in normal airways.FASEB J2004
12475759Role of airway surface liquid and submucosal glands in cystic fibrosis lung disease.Am J Physiol Cell Physiol2003
14644010CFTR pharmacology and its role in intestinal fluid secretion.Curr Opin Pharmacol2003
14557401Sodium and chloride concentrations, pH, and depth of airway surface liquid in distal airways.J Gen Physiol2003
11741919Chloride concentration in endosomes measured using a ratioable fluorescent Cl- indicator: evidence for chloride accumulation during acidification.J Biol Chem2002
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Collaborators

Pankaj B Agrawal
Broad Institute of MIT and Harvard
Co-authored papers 3
Christoph Klein
Kinderklinik und Kinderpoliklinik der Ludwig-Maximilians-Universitat Munchen
Co-authored papers 2
Iva Hafner-Bratkovi??
National Institute of Chemistry
Co-authored papers 2
Mark Donowitz
Johns Hopkins University School of Medicine
Co-authored papers 2
Ivan E Ivanov
Co-authored papers 1
Raymond L Dunn
University of California san francisco
Co-authored papers 1
Wiebke Jahr
Institute of Science and Technology Austria (ISTA)
Co-authored papers 1
Michael Anderson
Boston Children's Hospital
Co-authored papers 1
Mandeep Kaur
Post Graduate Institute of Medical Education and Research
Co-authored papers 1
Saul Kato
University of California san francisco
Co-authored papers 1
Grace Zhang
University of California berkeley
Co-authored papers 1
Kevin W Eliceiri
University of Wisconsin-Madison
Co-authored papers 1
Richard Baldock
Co-authored papers 1
Mark A Tsuchida
University of Wisconsin at Madison
Co-authored papers 1
Ramnik J Xavier
Broad Institute of MIT and Harvard
Co-authored papers 1
Seth L Alper
Beth Israel Deaconess Medical Center RN380F
Co-authored papers 1
Ken S Lau
Vanderbilt University School of Medicine
Co-authored papers 1
Irene Papatheodorou
Co-authored papers 1
Jose Ordovas-Montanes
Co-authored papers 1
Shalin B Mehta
Marine Biological Laboratory, Bell Center for Regenerative MedicineWoods Hole
Co-authored papers 1
Mark Puder
Boston Children's Hospital, Harvard Medical School
Co-authored papers 1
Nico Stuurman
University of California san francisco
Co-authored papers 1
John G Doench
Co-authored papers 1
Bin Li
University of Wisconsin at Madison
Co-authored papers 1
Bryant B Chhun
Co-authored papers 1
Ryan Mei
University of California berkeley
Co-authored papers 1
Ian Hunt
Tasmanian Institute of Agriculture, University of Tasmania
Co-authored papers 1
Loic A Royer
Center for Systems Biology Dresden
Co-authored papers 1
Michael Snyder
Stanford University
Co-authored papers 1
Nicholas M Anthony
Northwestern University
Co-authored papers 1
Release 1.2