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Author Details

Patrick J Casey
1973
213
73
PMIDPaper TitleJournal TitlePublished Year
34689178The emerging roles of Gα12/13 proteins on the hallmarks of cancer in solid tumors.Oncogene2022
36307864RAB4A GTPase regulates epithelial-to-mesenchymal transition by modulating RAC1 activation.Breast Cancer Research2022
34610973Suppression of isoprenylcysteine carboxylmethyltransferase compromises DNA damage repair.Life Science Alliance2021
33671920Evaluating the Epithelial-Mesenchymal Program in Human Breast Epithelial Cells Cultured in Soft Agar Using a Novel Macromolecule Extraction Protocol.Cancers2021
32561852Isoprenylcysteine carboxylmethyltransferase is required for the impact of mutant KRAS on TAZ protein level and cancer cell self-renewal.Oncogene2020
30824582Respiratory Capacity and Reserve Predict Cell Sensitivity to Mitochondria Inhibitors: Mechanism-Based Markers to Identify Metformin-Responsive Cancers.Mol Cancer Ther2019
31636124Gα-13 induces CC motif chemokine ligand 5 expression in prostate cancer cells by transactivating NF-κB.Journal of Biological Chemistry2019
31382612p21cip1/waf1 Coordinate Autophagy, Proliferation and Apoptosis in Response to Metabolic Stress.Cancers2019
29255247GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers.Oncogene2018
28192404Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms.Oncogene2017
28604748Isoprenylcysteine carboxylmethyltransferase function is essential for RAB4A-mediated integrin β3 recycling, cell migration and cancer metastasis.Oncogene2017
28394299c-Jun Contributes to Transcriptional Control of GNA12 Expression in Prostate Cancer Cells.Molecules2017
28167504Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer.Molecular Cancer Therapeutics2017
28166272Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif).PLoS ONE2017
26706195Inhibition of isoprenylcysteine carboxylmethyltransferase augments BCR-ABL1 tyrosine kinase inhibition-induced apoptosis in chronic myeloid leukemia.Experimental Hematology2016
27424208The GNA13-RhoA signaling axis suppresses expression of tumor protective Kallikreins.Cellular Signalling2016
26790532Protein prenylation: unique fats make their mark on biology.Nature Reviews Molecular Cell Biology2016
26989201GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo.Blood2016
26648485Protein Geranylgeranyltransferase Type 1 as a Target in Cancer.Current Cancer Drug Targets2016
25151967Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism.Oncogene2015
25889182MicroRNA-31 controls G protein alpha-13 (GNA13) expression and cell invasion in breast cancer cells.Molecular Cancer2015
24971579An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo.Cancer Biology and Therapy2014
24321455Gαz regulates BDNF-induction of axon growth in cortical neurons.Molecular and Cellular Neurosciences2014
24946790Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes.Experimental and Molecular Medicine2014
24976858Breast cancer cell invasion mediated by Gα12 signaling involves expression of interleukins-6 and -8, and matrix metalloproteinase-2.Journal of Molecular Signaling2014
23329838MicroRNA-182 and microRNA-200a control G-protein subunit α-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells.Journal of Biological Chemistry2013
23559002Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases.Cell Death and Disease2013
23514631Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt).European Journal of Medicinal Chemistry2013
23658012Control of RhoA methylation by carboxylesterase I.Journal of Biological Chemistry2013
21794202The effect of growth hormone (GH) and insulin-like growth factor-I (IGF-I) on in vitro maturation of equine oocytes.Zygote2012
22457354Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass.J Biol Chem2012
22087220G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion.PLoS ONE2011
21044946Site-specific analysis of protein S-acylation by resin-assisted capture.J Lipid Res2011
20798596RHO methylation matters: a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion.Cell Adhesion and Migration2011
21852230A role for Rac3 GTPase in the regulation of autophagy.Journal of Biological Chemistry2011
21628459Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis.Journal of Biological Chemistry2011
20541344The effects of systemic hypothermia on a murine model of thoracic aortic ischemia reperfusion.Journal of Vascular Surgery2010
20809634Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase.Journal of Medicinal Chemistry2010
20622895Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth.Oncogene2010
20529851A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity.Journal of Biological Chemistry2010
20339002Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation.J Biol Chem2010
20167843Pharmacological targeting of the mitochondrial phosphatase PTPMT1.J Pharmacol Exp Ther2010
19651782Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration.Journal of Biological Chemistry2009
19268911PJ34, a poly-ADP-ribose polymerase inhibitor, modulates visceral mitochondrial activity and CD14 expression following thoracic aortic ischemia-reperfusion.American Journal of Surgery2009
19482078Rho GTPase activity modulates Wnt3a/beta-catenin signaling.Cellular Signalling2009
19537691Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation.Journal of Medicinal Chemistry2009
19470770Activation of Rap1 promotes prostate cancer metastasis.Cancer Research2009
19158273Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe.Molecular and Cellular Biology2009
19157999A high-performance liquid chromatography method for the quantification of cysmethynil, an inhibitor of isoprenylcysteine carboxylmethyl transferase, in mouse plasma.Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences2009
19422395Role of G12 proteins in oncogenesis and metastasis.British Journal of Pharmacology2009
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