Author details

Full Name

George A Carlson

Affiliation

ORCID

Career Start Year

1976

Papers

157

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36634849	Fibril treatment changes protein interactions of tau and Î±-synuclein in human neurons.		2023
36651748	Therapeutic Trial of anle138b in Mouse Models of Genetic Prion Disease.		2023
33848474	Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components.	Neuron	2021
34064393	How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer's Disease and Other Neurodegenerative Disorders.	Int J Mol Sci	2021
32776089	Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints.	Nucleic Acids Res	2020
31959236	Core transcriptional regulatory circuits in prion diseases.	Mol Brain	2020
31109379	Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human Î±-synuclein.	Acta Neuropathol Commun	2019
30559471	Tau impairs neural circuits, dominating amyloid-Î² effects, in Alzheimer models in vivo.	Nat Neurosci	2019
29733334	Tau reduction in the presence of amyloid-Î² prevents tau pathology and neuronal death in vivo.	Brain	2018
28167615	The familial dysautonomia disease gene is required in the developing and adult mouse central nervous system.	DMM Disease Models and Mechanisms	2017
28500862	Enhanced Tau Aggregation in the Presence of Amyloid Î².	Am J Pathol	2017
28334820	High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds.	Hum Mol Genet	2017
28408124	Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau inÂ Vitro.	Am J Pathol	2017
28838658	Prion Protein and Genetic Susceptibility to Diseases Caused by Its Misfolding.	Progress in Molecular Biology and Translational Science	2017
28515043	Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer AÎ² Peptides.	Circ Res	2017
29203673	Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice.	Proc Natl Acad Sci U S A	2017
29157304	A novel vector for transgenesis in the rat CNS.	Acta Neuropathol Commun	2017
28196395	Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease.	Synapse	2017
28193724	Neurodegenerative Disease Transmission and Transgenesis in Mice.	Cold Spring Harb Perspect Biol	2017
27499529	Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy.	Cell Chem Biol	2016
27441645	Improvement of ENU Mutagenesis Efficiency Using Serial Injection and Mismatch Repair Deficiency Mice.	PLoS One	2016
26894278	A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone.	PLoS One	2016
27053712	Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis.	Human Molecular Genetics	2016
27351289	Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients.	Ann Neurol	2016
26851378	Brain Aggregates: An Effective In Vitro Cell Culture System Modeling Neurodegenerative Diseases.	J Neuropathol Exp Neurol	2016
27748574	Human tau increases amyloid Î² plaque size but not amyloid Î²-mediated synapse loss in a novel mouse model of Alzheimer's disease.	Eur J Neurosci	2016
26538322	Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity.	EMBO J	2015
25399070	Disrupted SOX10 function causes spongiform neurodegeneration in gray tremor mice.	Mamm Genome	2015
25853174	Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease.	Acta Neuropathol Commun	2015
26458742	Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.	Nat Commun	2015
24781082	Age-dependent neurovascular dysfunction and damage in a mouse model of cerebral amyloid angiopathy.	Stroke	2014
25361754	A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice.	Lipids in Health and Disease	2014
24271788	Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model.	Acta Neuropathol	2014
24326295	Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy.	Neuropharmacology	2014
24493590	Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs.	Journal of Cell Biology	2014
24462887	Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy.	Neurosci Lett	2014
25140287	Development of a novel cellular model of Alzheimer's disease utilizing neurosphere cultures derived from B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J embryonic mouse brain.	SpringerPlus	2014
23204056	Brain and circulating levels of AÎ²1-40 differentially contribute to vasomotor dysfunction in the mouse brain.	Stroke	2013
23946388	Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease.	J Neurosci	2013
24113653	Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400.	FEBS Letters	2013
23839581	Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology.	J Comp Neurol	2013
24278327	Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy.	PLoS One	2013
23787699	RML prions act through Mahogunin and Attractin-independent pathways.	Prion	2013
24173031	Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons.	Proceedings of the National Academy of Sciences of the United States of America	2013
23047530	Synaptic alterations in the rTg4510 mouse model of tauopathy.	J Comp Neurol	2013
23383230	Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion disease.	PLoS One	2013
23382216	Innate immunity receptor CD36 promotes cerebral amyloid angiopathy.	Proc Natl Acad Sci U S A	2013
21826404	The effect of HIV protease inhibitors on amyloid-Î² peptide degradation and synthesis in human cells and Alzheimer's disease animal model.	J Neuroimmune Pharmacol	2012
22507918	A brain aggregate model gives new insights into the pathobiology and treatment of prion diseases.	Journal of Neuropathology and Experimental Neurology	2012
22687393	LIV-1 ZIP ectodomain shedding in prion-infected mice resembles cellular response to transition metal starvation.	Journal of Molecular Biology	2012