Author details

Full Name

Stanley R Krystek

Affiliation

Bristol-Myers Squibb Pharmaceutical Research Institute

ORCID

Career Start Year

1985

Papers

H Index

Expertise

CM4AI Collaborator

Andrej Sali (CM4AI)

PMID	Paper Title	Journal Title	Published Year
34902431	Design for Solubility May Reveal Induction of Amide Hydrogen/Deuterium Exchange by Protein Self-Association.	J Mol Biol	2022
35545256	Target-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active Doses.	Drug Metab Dispos	2022
35179904	Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1<i>H</i>-pyrazol-1-yl)methyl)phosphonate (BMS-820132).	J Med Chem	2022
29135326	Hydrogen/deuterium exchange mass spectrometry and computational modeling reveal a discontinuous epitope of an antibody/TL1A Interaction.	MAbs	2018
30168197	AggScore: Prediction of aggregation-prone regions in proteins based on the distribution of surface patches.	Proteins	2018
29357216	Purity Determination by Capillary Electrophoresis Sodium Hexadecyl Sulfate (CE-SHS): A Novel Application For Therapeutic Protein Characterization.	Anal Chem	2018
27527097	Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry.	J Am Soc Mass Spectrom	2017
28193005	Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis.	Anal Chem	2017
28634122	Mapping the Binding Interface in a Noncovalent Size Variant of a Monoclonal Antibody Using Native Mass Spectrometry, Hydrogen-Deuterium Exchange Mass Spectrometry, and Computational Analysis.	J Pharm Sci	2017
27098672	Biotechnology Based Process for Production of a Disulfide-Bridged Peptide.	Bioconjug Chem	2016
27326332	Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARÎ± Selective Agonist.	ACS Med Chem Lett	2016
27216500	Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope.	J Mol Biol	2016
26824491	Isomerization and Oxidation in the Complementarity-Determining Regions of a Monoclonal Antibody: A Study of the Modification-Structure-Function Correlations by Hydrogen-Deuterium Exchange Mass Spectrometry.	Anal Chem	2016
25641333	Modeling the oxidation of methionine residues by peroxides in proteins.	J Pharm Sci	2015
26288692	Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer.	ACS Med Chem Lett	2015
25711416	Hydrogen/deuterium exchange mass spectrometry applied to IL-23 interaction characteristics: potential impact for therapeutics.	Expert Rev Proteomics	2015
25683677	Development and scale-up of the recovery and purification of a domain antibody Fc fusion protein-comparison of a two and three-step approach.	Biotechnol Bioeng	2015
22325775	Structures of adnectin/protein complexes reveal an expanded binding footprint.	Structure	2012
20218621	Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).	J Med Chem	2010
19217386	Outcome of a workshop on applications of protein models in biomedical research.	Structure	2009
19351168	N-aryl-oxazolidin-2-imine muscle selective androgen receptor modulators enhance potency through pharmacophore reorientation.	J Med Chem	2009
19459054	Closing the side-chain gap in protein loop modeling.	J Comput Aided Mol Des	2009
18291644	Identification and optimization of a novel series of [2.2.1]-oxabicyclo imide-based androgen receptor antagonists.	Bioorg Med Chem Lett	2008
18485702	Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.	Bioorg Med Chem Lett	2008
17008401	Pharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats.	Endocrinology	2007
17552509	Discovery of potent and muscle selective androgen receptor modulators through scaffold modifications.	J Med Chem	2007
17660258	Loopholes and missing links in protein modeling.	Protein Sci	2007
17292608	Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators.	Bioorg Med Chem Lett	2007
16683034	Chemical genetics reveals an RGS/G-protein role in the action of a compound.	PLoS Genet	2006
17054017	Modeling and active site refinement for G protein-coupled receptors: application to the beta-2 adrenergic receptor.	J Comput Aided Mol Des	2006
17181141	Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold.	J Med Chem	2006
16600967	A comparative study of available software for high-accuracy homology modeling: from sequence alignments to structural models.	Protein Sci	2006
15603938	Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists.	Bioorg Med Chem Lett	2005
15929997	Structural and functional characterization of CFE88: evidence that a conserved and essential bacterial protein is a methyltransferase.	Protein Sci	2005
16054241	Glycoprotein hormones tied but not tethered like other cysteine-knot cytokines.	Trends Pharmacol Sci	2005
15546739	The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists.	Bioorg Med Chem Lett	2004
12798389	Analysis and optimization of structure-based virtual screening protocols. 2. Examination of docked ligand orientation sampling methodology: mapping a pharmacophore for success.	J Mol Graph Model	2003
14517908	An assessment of protein-ligand binding site polarizability.	Biopolymers	2003
11320241	Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone.	Proc Natl Acad Sci U S A	2001
18429151	Protein secondary structure prediction.	Curr Protoc Protein Sci	2001
18429150	Hydrophobicity profiles for protein sequence analysis.	Curr Protoc Protein Sci	2001
11564568	High-throughput and virtual screening: core lead discovery technologies move towards integration.	Drug Discov Today	2000
8611558	Mutational analysis of the endothelin type A receptor (ETA): interactions and model of selective ETA antagonist BMS-182874 with putative ETA receptor binding cavity.	Biochemistry	1996
8845749	Simulated annealing with restrained molecular dynamics using a flexible restraint potential: theory and evaluation with simulated NMR constraints.	Protein Sci	1996
8785269	Factors influencing accuracy of computer-built models: a study based on leucine zipper GCN4 structure.	Biophys J	1996
7698331	Aspartate mutation distinguishes ETA but not ETB receptor subtype-selective ligand binding while abolishing phospholipase C activation in both receptors.	FEBS Lett	1995
7773179	A comparison of X-ray and NMR structures for human endothelin-1.	Protein Sci	1995
7861414	Three-dimensional quantitative structure-activity relationships of sulfonamide endothelin inhibitors.	J Med Chem	1995
8175640	Mutation of peptide binding site in transmembrane region of a G protein-coupled receptor accounts for endothelin receptor subtype selectivity.	J Biol Chem	1994
8226794	Micelle-bound conformational preferences of a peptide derived from a murine major histocompatibility complex class I molecule.	J Biol Chem	1993

1 - 50 of 63

Suwen Zhao

ShanghaiTech University, China iHuman Institute

Career Start Year 2006

Number of shared co-authors 2

Brian E Krumm

University of North Carolina School of Medicine

Career Start Year 2003

Number of shared co-authors 0

Hao Fan

College of Biotechnology and Bioengineering, Zhejiang University of Technology

Career Start Year 2001

Number of shared co-authors 4

Joseph D Ho

University of California san francisco

Career Start Year 2000

Number of shared co-authors 1

Udupi A Ramagopal

Poornaprajna Institute of Scientific Research (PPISR)

Career Start Year 1998

Number of shared co-authors 3

Eric Feyfant

Schrodinger Inc.

Career Start Year 1997

Number of shared co-authors 3

Mallur S Madhusudhan

Indian Institute of Science Education and Research Pune

Career Start Year 1996

Number of shared co-authors 4

Shane Atwell

Lilly Research Laboratories

Career Start Year 1994

Number of shared co-authors 6

Paul A Bates

The Francis Crick Institute

Career Start Year 1989

Number of shared co-authors 4

David E Timm

Lilly Research Laboratories

Career Start Year 1988

Number of shared co-authors 2

Raymond C Stevens

iHuman Institute, ShanghaiTech University

Career Start Year 1988

Number of shared co-authors 9

Miriam Eisenstein

Weizmann Institute of Science

Career Start Year 1988

Number of shared co-authors 4

Herman W T van Vlijmen

Leiden Academic Centre for Drug Research (LACDR), Leiden University

Career Start Year 1988

Number of shared co-authors 1

Steven C Almo

Albert Einstein College of Medicine

Career Start Year 1988

Number of shared co-authors 8

Paul C Driscoll

The Francis Crick Institute

Career Start Year 1987

Number of shared co-authors 2

Diane Joseph-McCarthy

Boston University

Career Start Year 1987

Number of shared co-authors 2

Piotr Cieplak

Sanford-Burnham-Prebys Medical Discovery Institute

Career Start Year 1987

Number of shared co-authors 2

Mark S Johnson

Abo Akademi University

Career Start Year 1985

Number of shared co-authors 1

William F DeGrado

Department of Pharmaceutical Chemistry, University of California san francisco

Career Start Year 1982

Number of shared co-authors 4

Ruben Abagyan

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California

Career Start Year 1981

Number of shared co-authors 1

Michael J E Sternberg

Imperial College London

Career Start Year 1976

Number of shared co-authors 6

David S Moss

Institute of Structural and Molecular Biology, University of London

Career Start Year 1976

Number of shared co-authors 1

Charles L Brooks

University of Michigan ann arbor

Career Start Year 1974

Number of shared co-authors 4

James A Wells

Department of Pharmaceutical Chemistry, University of California San Francisco

Career Start Year 1974

Number of shared co-authors 4

Tom L Blundell

Heartand Lung Research Institute, University of Cambridge

Career Start Year 1971

Number of shared co-authors 3

Bernard Maigret

Universite de Lorraine, CNRS

Career Start Year 1970

Number of shared co-authors 3

Wayne A Hendrickson

Columbia University

Career Start Year 1968

Number of shared co-authors 7

David Eisenberg

university of california los angeles

Career Start Year 1963

Number of shared co-authors 2

Chandrasekaran Ramakrishnan

Indian Institute of Technology Madras

Career Start Year 1962

Number of shared co-authors 1

Jens Meiler

Vanderbilt University

Career Start Year 1954

Number of shared co-authors 10

row(s) 1 - 30 of 30

Terry R Stouch

Lexicon Pharmaceuticals

Co-authored papers 7

Donna A Bassolino

Co-authored papers 6

Robert Bruccoleri

Co-authored papers 4

Gaetano T Montelione

Rensselaer Polytechnic Institute

Co-authored papers 2

Andrej Sali (CM4AI)

University of California San Francisco

Co-authored papers 1

Krzysztof Fidelis

University of California davis

Co-authored papers 1

Lynn Bjerke

Co-authored papers 1

Christine Humblet

Lilly Research Laboratories

Co-authored papers 1

Torsten Schwede

University of Basel

Co-authored papers 1

Stephen K Burley

The State University of New Jersey

Co-authored papers 1

Andras Fiser

Albert Einstein College of Medicine

Co-authored papers 1

Ian A Wilson

The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology

Co-authored papers 1

David Jones

The Francis Crick Institute

Co-authored papers 1

Steven E Brenner

University of California berkeley

Co-authored papers 1

Barry Honig

Columbia University Irving Medical Center

Co-authored papers 1

Andrzej Joachimiak

Center for Structural Biology of Infectious Diseases, University of Chicago

Co-authored papers 1

John Moult

Institute for Bioscience and Biotechnology Research

Co-authored papers 1

Roland L Dunbrack

Fox Chase Cancer Center

Co-authored papers 1

Rhiju Das

Stanford University School of Medicine

Co-authored papers 1

Helen M Berman

The State University of New Jersey

Co-authored papers 1

John D Westbrook

The State University of New Jersey

Co-authored papers 1

Michael L Gross

Washington University in St. Louis

Co-authored papers 1

M V??squez

Cornell University

Co-authored papers 1

Matthew P Jacobson

Department of Pharmaceutical Chemistry, University of California san francisco

Co-authored papers 1

Kevin Fitzgerald

Co-authored papers 1

Sandor Vajda

Boston University

Co-authored papers 1

Daron M Standley

Osaka university

Co-authored papers 1

Tobin R Sosnick

Institute for Biophysical Dynamics, The University of Chicago

Co-authored papers 1

Nikolay V Dokholyan

Pennsylvania State University College of Medicine

Co-authored papers 1

Yuanpeng J Huang

Center for Advanced Biotechnology and Medicine, The State University of New Jersey

Co-authored papers 1

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