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Author Details

Karen N Allen
Boston University
1989
120
41
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
38019455Specificity determinants revealed by the structure of glycosyltransferase Campylobacter concisus PglA.Protein Sci2024
37096962Co-conserved sequence motifs are predictive of substrate specificity in a family of monotopic phosphoglycosyl transferases.Protein Sci2023
30337134Monotopic Membrane Proteins Join the Fold.Trends Biochem Sci2019
29769739Membrane association of monotopic phosphoglycosyl transferase underpins function.Nat Chem Biol2018
29812904Crystallography Coupled with Kinetic Analysis Provides Mechanistic Underpinnings of a Nicotine-Degrading Enzyme.Biochemistry2018
30149871Preface.Methods Enzymol2018
30149857Crystallization of Liganded Phosphatases in the HAD Superfamily.Methods Enzymol2018
29952545Mechanism of Substrate Recognition and Catalysis of the Haloalkanoic Acid Dehalogenase Family Member α-Phosphoglucomutase.Biochemistry2018
30194316X-ray Fluorescence Nanotomography of Single Bacteria with a Sub-15â¿¿nm Beam.Sci Rep2018
29581267Exploring the structural origins of cryptic sites on proteins.Proc Natl Acad Sci U S A2018
29695157Structural Basis of the Molecular Switch between Phosphatase and Mutase Functions of Human Phosphomannomutase 1 under Ischemic Conditions.Biochemistry2018
28741300Catalytic Mechanism of the Hotdog-Fold Thioesterase PA1618 Revealed by X-ray Structure Determination of a Substrate-Bound Oxygen Ester Analogue Complex.Chembiochem2017
28189581Construction and Analysis of Two Genome-Scale Deletion Libraries for Bacillus subtilis.Cell Syst2017
28475321Metal Ions Effectively Ablate the Action of Botulinum Neurotoxin A.J Am Chem Soc2017
28698055Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A.Toxicon2017
28534082Conformational dynamics and alignment properties of loop lanthanide-binding-tags (LBTs) studied in interleukin-1β.J Biomol NMR2017
27014926Substrate Binding Mode and Molecular Basis of a Specificity Switch in Oxalate Decarboxylase.Biochemistry2016
27933790Structural Analysis Provides Mechanistic Insight into Nicotine Oxidoreductase from Pseudomonas putida.Biochemistry2016
27526404Catalytic scaffolds for phosphoryl group transfer.Curr Opin Struct Biol2016
25513739Covalent docking predicts substrates for haloalkanoate dehalogenase superfamily phosphatases.Biochemistry2015
26600273Conservation and Covariance in Small Bacterial Phosphoglycosyltransferases Identify the Functional Catalytic Core.Biochemistry2015
26341230Encoded loop-lanthanide-binding tags for long-range distance measurements in proteins by NMR and EPR spectroscopy.J Biomol NMR2015
26440863Enzyme Substrate Specificity Conferred by Distinct Conformational Pathways.J Am Chem Soc2015
26095982Accounting for observed small angle X-ray scattering profile in the protein-protein docking server ClusPro.J Comput Chem2015
25848029Panoramic view of a superfamily of phosphatases through substrate profiling.Proc Natl Acad Sci U S A2015
24444454Assigning the EPR fine structure parameters of the Mn(II) centers in Bacillus subtilis oxalate decarboxylase by site-directed mutagenesis and DFT/MM calculations.J Am Chem Soc2014
25210039Enzyme promiscuity: engine of evolutionary innovation.J Biol Chem2014
25400026Disulfide-mediated stabilization of the IκB kinase binding domain of NF-κB essential modulator (NEMO).Biochemistry2014
25010423Structure and catalysis in the Escherichia coli hotdog-fold thioesterase paralogs YdiI and YbdB.Biochemistry2014
24992697Divergence of substrate specificity and function in the Escherichia coli hotdog-fold thioesterase paralogs YdiI and YbdB.Biochemistry2014
24992307Structure of the trehalose-6-phosphate phosphatase from Brugia malayi reveals key design principles for anthelmintic drugs.PLoS Pathog2014
24791931Substrate deconstruction and the nonadditivity of enzyme recognition.J Am Chem Soc2014
24577717Structure-guided approach for detecting large domain inserts in protein sequences as illustrated using the haloacid dehalogenase superfamily.Proteins2014
23340139Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies.Bioorg Med Chem2013
24266532Mutation of nonessential cysteines shows that the NF-κB essential modulator forms a constitutive noncovalent dimer that binds IκB kinase-β with high affinity.Biochemistry2013
23851007Co-evolution of HAD phosphatase and hotdog-fold thioesterase domain function in the menaquinone-pathway fusion proteins BF1314 and PG1653.FEBS Lett2013
23848398Structural basis for the divergence of substrate specificity and biological function within HAD phosphatases in lipopolysaccharide and sialic acid biosynthesis.Biochemistry2013
23989152Neutron diffraction studies towards deciphering the protonation state of catalytic residues in the bacterial KDN9P phosphatase.Acta Crystallogr Sect F Struct Biol Cryst Commun2013
23959887Consequences of domain insertion on sequence-structure divergence in a superfold.Proc Natl Acad Sci U S A2013
22404040A structural element that facilitates proton-coupled electron transfer in oxalate decarboxylase.Biochemistry2012
23150430Tailoring encodable lanthanide-binding tags as MRI contrast agents.Chembiochem2012
22224443Quaternary ammonium oxidative demethylation: X-ray crystallographic, resonance Raman, and UV-visible spectroscopic analysis of a Rieske-type demethylase.J Am Chem Soc2012
21182275Engineering encodable lanthanide-binding tags into loop regions of proteins.J Am Chem Soc2011
21999478The Enzyme Function Initiative.Biochemistry2011
21995300Binding energy and catalysis by D-xylose isomerase: kinetic, product, and X-ray crystallographic analysis of enzyme-catalyzed isomerization of (R)-glyceraldehyde.Biochemistry2011
21989931The X-ray crystallographic structure and specificity profile of HAD superfamily phosphohydrolase BT1666: comparison of paralogous functions in B. thetaiotaomicron.Proteins2011
21894910Divergence of structure and function in the haloacid dehalogenase enzyme superfamily: Bacteroides thetaiotaomicron BT2127 is an inorganic pyrophosphatase.Biochemistry2011
21413788Homo sapiens dullard protein phosphatase shows a preference for the insulin-dependent phosphorylation site of lipin1.Biochemistry2011
21203627A cross-over inhibitor of the botulinum neurotoxin light chain B: a natural product implicating an exosite mechanism of action.Chem Commun (Camb)2011
20102793Lanthanide-tagged proteins--an illuminating partnership.Curr Opin Chem Biol2010
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Collaborators

Debra Dunaway-Mariano
University of New Mexico
Co-authored papers 46
Ezra Peisach
The State University of New Jersey
Co-authored papers 7
Steven C Almo
Albert Einstein College of Medicine
Co-authored papers 6
Chetanya Pandya
Icahn School of Medicine at Mount Sinai
Co-authored papers 5
Patricia C Babbitt
University of California san francisco
Co-authored papers 4
Gregory A Petsko
Helen and Robert Appel Alzheimer's Disease Research Institute, Cornell University
Co-authored papers 4
Marc C Morais
University of Texas Medical Branch
Co-authored papers 4
Brian K Shoichet
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 3
Sandor Vajda
Boston University
Co-authored papers 3
Dima Kozakov
Stony Brook University
Co-authored papers 3
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University of California san francisco
Co-authored papers 2
Yury Patskovsky
New York University Grossman School of Medicine
Co-authored papers 2
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Cardiovascular Research Unit, Newark Beth Israel Medical Center
Co-authored papers 2
Frank M Raushel
Texas A&M University, College Station
Co-authored papers 2
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National Center for Biotechnology Information, National Institutes of Health
Co-authored papers 2
Shoshana D Brown
University of California san francisco
Co-authored papers 2
Katherine H O'Toole
Boston University
Co-authored papers 2
Lingqi Luo
Co-authored papers 2
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 2
Yu Xia
College of Information Engineering, Zhejiang University of Technology
Co-authored papers 2
Athanasios Typas
University of California san francisco
Co-authored papers 1
John E Cronan
University of Illinois
Co-authored papers 1
Rafael Toro
Medical College of Wisconsin
Co-authored papers 1
Jeremy D Selengut
Craig Venter Institute, 9704 Medical Center Drive
Co-authored papers 1
J Michael Sauder
Eli Lilly and Co.
Co-authored papers 1
Nir London
The Weizmann Institute of Science
Co-authored papers 1
Catherine E Costello
Center for Biomedical Mass Spectrometry, Boston University
Co-authored papers 1
Tanya Z Berardini
Carnegie Institution for Science
Co-authored papers 1
Richard N Armstrong
The Hospital for Sick Children
Co-authored papers 1
Sarah Barelier
CNRS, Aix-Marseille University
Co-authored papers 1
Release 1.2