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Author Details

Dominic A Scudiero
1971
90
51
PMIDPaper TitleJournal TitlePublished Year
23437320A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept.PLoS One2013
22766217Discovery and preliminary SAR of bisbenzylisoquinoline alkaloids as inducers of C/EBPα.Bioorg Med Chem2012
22460269Impact of mutant β-catenin on ABCB1 expression and therapy response in colon cancer cells.Br J Cancer2012
22870217Identification of CBX3 and ABCA5 as putative biomarkers for tumor stem cells in osteosarcoma.PLoS One2012
21685359Novel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancer.J Natl Cancer Inst2011
21795396S100A4-induced cell motility and metastasis is restricted by the Wnt/β-catenin pathway inhibitor calcimycin in colon cancer cells.Mol Biol Cell2011
21749055Cysteine 81 is critical for the interaction of S100A4 and myosin-IIA.Biochemistry2011
21794960Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors.Eur J Med Chem2011
21593990RSK2 Binding Models Delineate Key Features for Activity.J Chem Pharm Res2010
20178109Complex display of putative tumor stem cell markers in the NCI60 tumor cell line panel.Stem Cells2010
2017611112 Arylstibonic acids that inhibit the DNA binding of five B-ZIP dimers.J Struct Biol2010
20362353The arylstibonic acid compound NSC13746 disrupts B-ZIP binding to DNA in living cells.Eur J Cell Biol2010
19405508Cytotoxic and HIF-1alpha inhibitory compounds from Crossosoma bigelovii.J Nat Prod2009
19093800Inhibitors of the NF-kappaB activation pathway from Cryptocarya rugulosa.J Nat Prod2009
18199535Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen.Cancer Res2008
18302092Separation and SAR study of HIF-1alpha inhibitory tubulosines from Alangium cf. longiflorum.Planta Med2008
17616632Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase.Mol Pharmacol2007
17330085Development of recombinant adeno-associated virus vectors carrying small interfering RNA (shHec1)-mediated depletion of kinetochore Hec1 protein in tumor cells.Gene Ther2007
17272646Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells.Mol Cancer Ther2007
17315309Identification of a new natural camptothecin analogue in targeted screening for HIF-1alpha inhibitors.Planta Med2007
17339364Transcript and protein expression profiles of the NCI-60 cancer cell panel: an integromic microarray study.Mol Cancer Ther2007
16648555Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel.Mol Cancer Ther2006
16397212Ligand-directed surface profiling of human cancer cells with combinatorial peptide libraries.Cancer Res2006
16723234Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore.Bioorg Med Chem2006
15840499A high-throughput fluorescence-anisotropy screen that identifies small molecule inhibitors of the DNA binding of B-ZIP transcription factors.Anal Biochem2005
16103101Substituted purine analogues define a novel structural class of catalytic topoisomerase II inhibitors.Cancer Res2005
14749124Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.Cancer Cell2004
15501957Components of the cell death machine and drug sensitivity of the National Cancer Institute Cell Line Panel.Clin Cancer Res2004
14500354Diagnostic markers that distinguish colon and ovarian adenocarcinomas: identification by genomic, proteomic, and tissue array profiling.Cancer Res2003
12927820A high-throughput screen for identification of molecular mimics of Smac/DIABLO utilizing a fluorescence polarization assay.Anal Biochem2003
14695175Karyotypic complexity of the NCI-60 drug-screening panel.Cancer Res2003
14502277Identification of PDGFR as a receptor for AAV-5 transduction.Nat Med2003
11944818Application of high-throughput, molecular-targeted screening to anticancer drug discovery.Curr Top Med Chem2002
12045463DNA repair protein levels vis-à-vis anticancer drug resistance in the human tumor cell lines of the National Cancer Institute drug screening program.Anticancer Drugs2002
12451985Nucleotide excision repair protein levels vis-à-vis anticancer drug resistance in 60 human tumor cell lines.Ai Zheng2002
12154035Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway.Cancer Res2002
11290551Expression and potential role of Fas-associated phosphatase-1 in ovarian cancer.Am J Pathol2001
11181500P450 enzyme expression patterns in the NCI human tumor cell line panel.Drug Metab Dispos2001
10815900Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.Clin Cancer Res2000
10700175A gene expression database for the molecular pharmacology of cancer.Nat Genet2000
11085534An informatics approach identifying markers of chemosensitivity in human cancer cell lines.Cancer Research2000
9679980Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines.Cancer Res1998
9850056IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs.Cancer Research1998
9422523Expression and location of pro-apoptotic Bcl-2 family protein BAD in normal human tissues and tumor cell lines.Am J Pathol1998
9625176Cell line designation change: multidrug-resistant cell line in the NCI anticancer screen.J Natl Cancer Inst1998
8994024An information-intensive approach to the molecular pharmacology of cancer.Science1997
9331090Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.Cancer Res1997
9365500The NCI anti-cancer drug screen: a smart screen to identify effectors of novel targets.Anticancer Drug Des1997
9150955A protein expression database for the molecular pharmacology of cancer.Electrophoresis1997
8631022An abnormality in the p53 pathway following gamma-irradiation in many wild-type p53 human melanoma lines.Cancer Res1996
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and Blood Institute, National Institutes of Health
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