|
| 36497283 | Identification of a Small Molecule Inhibitor of Hyaluronan Synthesis, DDIT, Targeting Breast Cancer Cells. | | 2022 |
| 33637727 | Comprehensive analysis of single cell ATAC-seq data with SnapATAC. | Nat Commun | 2021 |
| 33170211 | Centriole-independent mitotic spindle assembly relies on the PCNT-CDK5RAP2 pericentriolar matrix. | Journal of Cell Biology | 2020 |
| 32908304 | TRIM37 controls cancer-specific vulnerability to PLK4 inhibition. | Nature | 2020 |
| 30707971 | Differential effect of inhibitory strategies of the V617 mutant of JAK2 on cytokine receptor signaling. | Journal of Allergy and Clinical Immunology | 2019 |
| 31821785 | Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair. | Cancer Cell | 2019 |
| 31085179 | Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair. | Cancer Cell | 2019 |
| 30827889 | Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair. | Cancer Cell | 2019 |
| 29736709 | Phenotypic Screening for Inhibitors of a Mutant Thrombopoietin Receptor. | Methods in Molecular Biology | 2018 |
| 30377272 | CFI-400945 is not a selective cellular PLK4 inhibitor. | Proceedings of the National Academy of Sciences of the United States of America | 2018 |
| 29255264 | Identification of H3K4me1-associated proteins at mammalian enhancers. | Nat Genet | 2018 |
| 28724615 | Glioblastoma cellular cross-talk converges on NF-κB to attenuate EGFR inhibitor sensitivity. | Genes Dev | 2017 |
| 28648777 | mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. | Mol Cell | 2017 |
| 27746144 | An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers. | Cancer Cell | 2016 |
| 27432897 | 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. | J Cell Biol | 2016 |
| 27430378 | Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation. | Scientific Reports | 2016 |
| 26983878 | Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells. | Mol Cancer Ther | 2016 |
| 27029346 | Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 αC helix. | Biochem J | 2016 |
| 27708138 | GOLPH3 drives cell migration by promoting Golgi reorientation and directional trafficking to the leading edge. | Molecular Biology of the Cell | 2016 |
| 27748177 | A Phenotypic Screen for Small-Molecule Inhibitors of Constitutively Active Mutant Thrombopoietin Receptor Implicated in Myeloproliferative Neoplasms. | Combinatorial Chemistry and High Throughput Screening | 2016 |
| 26455392 | EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling. | Mol Cell | 2015 |
| 25931445 | Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. | Science | 2015 |
| 26732741 | A Cell Biologist's Field Guide to Aurora Kinase Inhibitors. | Frontiers in Oncology | 2015 |
| 26119738 | Natural Loss of Mps1 Kinase in Nematodes Uncovers a Role for Polo-like Kinase 1 in Spindle Checkpoint Initiation. | Cell Reports | 2015 |
| 24920825 | Common regulatory control of CTP synthase enzyme activity and filament formation. | Molecular Biology of the Cell | 2014 |
| 23673331 | Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly. | Developmental Cell | 2013 |
| 22182498 | Heteroaromatic-aminomethyl quinolones: potent and selective iNOS inhibitors. | Bioorg Med Chem Lett | 2012 |
| 22901900 | Discovery and optimization of a series of liver X receptor antagonists. | Bioorganic and Medicinal Chemistry Letters | 2012 |
| 22406115 | Discovery of a new binding mode for a series of liver X receptor agonists. | Bioorganic and Medicinal Chemistry Letters | 2012 |
| 21986586 | Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors. | Bioorg Med Chem Lett | 2011 |
| 21036913 | Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases. | J Pharmacol Exp Ther | 2011 |
| 20378348 | Water-soluble PDE4 inhibitors for the treatment of dry eye. | Bioorganic and Medicinal Chemistry Letters | 2010 |
| 20801037 | Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5. | Bioorg Med Chem Lett | 2010 |
| 20931971 | Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNOS dimerization inhibitors that are orally active in pain models. | J Med Chem | 2010 |
| 20434334 | Benzothiophene containing Rho kinase inhibitors: Efficacy in an animal model of glaucoma. | Bioorg Med Chem Lett | 2010 |
| 19374401 | Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models. | J Med Chem | 2009 |
| 19364813 | KLYP956 is a non-imidazole-based orally active inhibitor of nitric-oxide synthase dimerization. | Mol Pharmacol | 2009 |
| 18483295 | KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo. | Mol Cancer Ther | 2008 |
| 20161838 | Inhibition of inducible nitric oxide synthase expression by a novel small molecule activator of the unfolded protein response. | Curr Chem Genomics | 2008 |
| 18954983 | Identification of KD5170: a novel mercaptoketone-based histone deacetylase inhibitor. | Bioorg Med Chem Lett | 2008 |
| 18336215 | Back to basics: label-free technologies for small molecule screening. | Combinatorial Chemistry and High Throughput Screening | 2008 |
| 17498954 | Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors. | Bioorg Med Chem Lett | 2007 |
| 17055434 | Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements. | Cell | 2006 |
| 15248503 | A structural explanation for ERalpha/ERbeta SERM discrimination. | Ernst Schering Research Foundation workshop | 2004 |
| 15274928 | The crystal structure of the carboxy-terminal dimerization domain of htpG, the Escherichia coli Hsp90, reveals a potential substrate binding site. | Structure | 2004 |
| 11953755 | Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism. | Nat Struct Biol | 2002 |
| 12825453 | Orphan nuclear receptors: from new ligand discovery technologies to novel signaling pathways. | Current Opinion in Drug Discovery and Development | 2001 |
| 11222741 | Hormone selectivity in thyroid hormone receptors. | Mol Endocrinol | 2001 |
| 11162939 | Estrogen receptor pathways to AP-1. | J Steroid Biochem Mol Biol | 2000 |
| 9875847 | The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. | Cell | 1998 |