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Author Details

Lani F Wu
Department of Pharmaceutical Chemistry, University of California san francisco
2001
65
30
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36711978Selection of optimal cell lines for high-content phenotypic screening.bioRxiv2023
37851575A PINK1 input threshold arises from positive feedback in the PINK1/Parkin mitophagy decision circuit.Cell Rep2023
37494095Searching for molecular hypoxia sensors among oxygen-dependent enzymes.Elife2023
37141099Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity.Cell Rep2023
37398257Small Molecule <i>in situ</i> Resin Capture - A Compound First Approach to Natural Product Discovery.bioRxiv2023
36480300Biallelic TET2 mutations confer sensitivity to 5'-azacitidine in acute myeloid leukemia.JCI Insight2023
36920184Selection of Optimal Cell Lines for High-Content Phenotypic Screening.ACS Chem Biol2023
35087225Differential toxicity to murine small and large intestinal epithelium induced by oncology drugs.Commun Biol2022
35505109Publisher Correction: Integrative spatial analysis of cell morphologies and transcriptional states with MUSE.Nat Biotechnol2022
35347329Integrative spatial analysis of cell morphologies and transcriptional states with MUSE.Nat Biotechnol2022
35089788Modulating environmental signals to reveal mechanisms and vulnerabilities of cancer persisters.Sci Adv2022
33472066Systematic alteration of in vitro metabolic environments reveals empirical growth relationships in cancer cell phenotypes.Cell Rep2021
33484640Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition.Dev Cell2021
34731164Analysis of growth cone extension in standardized coordinates highlights self-organization rules during wiring of the Drosophila visual system.PLoS Genet2021
32619551Loss of TET2 Affects Proliferation and Drug Sensitivity through Altered Dynamics of Cell-State Transitions.Cell Syst2020
32705637Generation and Quantitative Imaging of Enteroid Monolayers.Methods Mol Biol2020
30886411Scalable analysis of cell-type composition from single-cell transcriptomics using deep recurrent learning.Nat Methods2019
31672976A multi-modal data resource for investigating topographic heterogeneity in patient-derived xenograft tumors.Sci Data2019
31204100Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy.Cell2019
29525203Modeling Cell-to-Cell Communication Networks Using Response-Time Distributions.Cell Syst2018
30015158Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance.Neoplasia2018
30740553Drug persistence - from antibiotics to cancer therapies.Curr Opin Syst Biol2018
29503158Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization.Dev Cell2018
27895117Examining Crosstalk among Transforming Growth Factor β, Bone Morphogenetic Protein, and Wnt Pathways.J Biol Chem2017
28377453Combination Therapy Targeting BCL6 and Phospho-STAT3 Defeats Intratumor Heterogeneity in a Subset of Non-Small Cell Lung Cancers.Cancer Res2017
28869755Sampling strategies to capture single-cell heterogeneity.Nat Methods2017
26891683Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells.Nat Commun2016
26655497Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines.Nat Biotechnol2016
27965424Chemoattractant concentration-dependent tuning of ERK signaling dynamics in migrating neutrophils.Sci Signal2016
27280401Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration.PLoS Biol2016
27307643PHOCOS: inferring multi-feature phenotypic crosstalk networks.Bioinformatics2016
25402767GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors.Nat Chem Biol2015
26119341The Developmental Rules of Neural Superposition in Drosophila.Cell2015
25739453Homer3 regulates the establishment of neutrophil polarity.Mol Biol Cell2015
25425168On comparing heterogeneity across biomarkers.Cytometry A2015
24686220Rapid analysis and exploration of fluorescence microscopy images.J Vis Exp2014
24912630The evolution and development of neural superposition.J Neurogenet2014
24874571A simple image correction method for high-throughput microscopy.Nat Methods2014
23660413Envisioning migration: mathematics in both experimental analysis and modeling of cell behavior.Curr Opin Cell Biol2013
23665220Identifying network motifs that buffer front-to-back signaling in polarized neutrophils.Cell Rep2013
22341450Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit.Cell2012
22743764PhenoRipper: software for rapidly profiling microscopy images.Nat Methods2012
22743763SimuCell: a flexible framework for creating synthetic microscopy images.Nat Methods2012
22632971Network crosstalk dynamically changes during neutrophil polarization.Cell2012
22265410Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration.Cell2012
22102805A density-dependent switch drives stochastic clustering and polarization of signaling molecules.PLoS Comput Biol2011
20461076Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities.Mol Syst Biol2010
20725643ON IDENTIFYING INFORMATION FROM IMAGE-BASED SPATIAL POLARITY PHENOTYPES IN NEUTROPHILS.Proc IEEE Int Symp Biomed Imaging2010
20478246Cellular heterogeneity: do differences make a difference?Cell2010
19767759An approach for extensibly profiling the molecular states of cellular subpopulations.Nat Methods2009
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Collaborators

Steven J Altschuler
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 64
Michael D Slack
Simmons Cancer Center, University of Texas Southwestern Medical Center
Co-authored papers 4
John D Minna
University of Texas Southwestern Medical Center at Dallas
Co-authored papers 3
Matthew P Jacobson
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 3
Timothy R Hughes
University of Toronto
Co-authored papers 2
Melanie H Cobb
Co-authored papers 2
Mark D Robinson
University of Zurich
Co-authored papers 2
Jack F Greenblatt
College Street, University of Toronto
Co-authored papers 2
Oliver J Rando
University of Massachusetts Chan Medical School
Co-authored papers 2
Armaity P Davierwala
Max Planck Institute for Evolutionary Anthropology
Co-authored papers 2
Andrew Emili
Boston University School of Medicine, Boston University
Co-authored papers 2
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 2
Peter Robin Hiesinger
Co-authored papers 2
Mark Kittisopikul
Howard Hughes Medical Institute
Co-authored papers 1
John D Gordan
Quantitative Biosciences Institute (QBI), University of California San Francisco
Co-authored papers 1
John W Phillips
University of California los angeles
Co-authored papers 1
Vladimir Jojic
Calico Life Sciences LLC
Co-authored papers 1
Bryan Beattie
University Hospital of Wales
Co-authored papers 1
Wen-Tao Peng
West China Second University Hospital, Sichuan University
Co-authored papers 1
Chris Pal
Co-authored papers 1
Sam Roweis
University College London
Co-authored papers 1
Robert J Nichols
Stanford University
Co-authored papers 1
Steven E Scherer
Baylor College of Medicine
Co-authored papers 1
Anthony J O'Donoghue
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
Co-authored papers 1
Scott R VandenBerg
University of California san francisco
Co-authored papers 1
Eric E Schadt
Icahn School of Medicine at Mount Sinai
Co-authored papers 1
Brendan J Frey
University of Toronto
Co-authored papers 1
Karolina Maciag
Broad Institute of MIT and Harvard
Co-authored papers 1
Sanie Mnaimneh
University of Toronto
Co-authored papers 1
Friedrich St??lzel
University Hospital TU Dresden
Co-authored papers 1
Release 1.2