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Author Details

John A Gerlt
University of Illinois at Urbana-Champaign
1973
191
54
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36729913Pyridoxal 5'-phosphate synthesis and salvage in Bacteria and Archaea: predicting pathway variant distributions and holes.Microb Genom2023
37356897EFI-EST, EFI-GNT, and EFI-CGFP: Enzyme Function Initiative (EFI) Web Resource for Genomic Enzymology Tools.J Mol Biol2023
36119373RadicalSAM.org: A Resource to Interpret Sequence-Function Space and Discover New Radical SAM Enzyme Chemistry.ACS Bio Med Chem Au2022
35961013A roadmap for the functional annotation of protein families: a community perspective.Database (Oxford)2022
33418450Discovery of new enzymatic functions and metabolic pathways using genomic enzymology web tools.Curr Opin Biotechnol2021
34652139Epoxyqueuosine Reductase QueH in the Biosynthetic Pathway to tRNA Queuosine Is a Unique Metalloenzyme.Biochemistry2021
34015914Evolution of Enzyme Function and the Development of Catalytic Efficiency: Triosephosphate Isomerase, Jeremy R. Knowles, and W. John Albery.Biochemistry2021
33197748Discovery of novel pathways for carbohydrate metabolism.Curr Opin Chem Biol2021
31917558Characterization of an l-Ascorbate Catabolic Pathway with Unprecedented Enzymatic Transformations.J Am Chem Soc2020
31925306The gastrointestinal pathogen Campylobacter jejuni metabolizes sugars with potential help from commensal Bacteroides vulgatus.Commun Biol2020
31950558A bifunctional salvage pathway for two distinct S-adenosylmethionine by-products that is widespread in bacteria, including pathogenic Escherichia coli.Mol Microbiol2020
31481610Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens.Proc Natl Acad Sci U S A2019
31888339Special Issue: Current Topics in Mechanistic Enzymology 2019.Biochemistry2019
31553576The EFI Web Resource for Genomic Enzymology Tools: Leveraging Protein, Genome, and Metagenome Databases to Discover Novel Enzymes and Metabolic Pathways.Biochemistry2019
29377793Prediction of enzymatic pathways by integrative pathway mapping.Elife2018
29867142Functional assignment of multiple catabolic pathways for D-apiose.Nat Chem Biol2018
29865796Special Issue: Current Topics in Mechanistic Enzymology.Biochemistry2018
30249705Novel Metabolic Pathways and Regulons for Hexuronate Utilization in Proteobacteria.J Bacteriol2018
30497880Editorial overview: Novel enzymes, coenzymes, and metabolic pathways.Curr Opin Chem Biol2018
30268904'Democratized' genomic enzymology web tools for functional assignment.Curr Opin Chem Biol2018
30475611Enzyme Architecture: Breaking Down the Catalytic Cage that Activates Orotidine 5'-Monophosphate Decarboxylase for Catalysis.J Am Chem Soc2018
28826221Genomic Enzymology: Web Tools for Leveraging Protein Family Sequence-Function Space and Genome Context to Discover Novel Functions.Biochemistry2017
26978037Correction to "A General Strategy for the Discovery of Metabolic Pathways: D-Threitol, L-Threitol, and Erythritol Utilization in Mycobacterium smegmatis".J Am Chem Soc2016
27303900Structure of an ABC transporter solute-binding protein specific for the amino sugars glucosamine and galactosamine.Acta Crystallogr F Struct Biol Commun2016
27294475Members of a Novel Kinase Family (DUF1537) Can Recycle Toxic Intermediates into an Essential Metabolite.ACS Chem Biol2016
27402745Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars.Proc Natl Acad Sci U S A2016
26750482Purification, crystallization and structural elucidation of D-galactaro-1,4-lactone cycloisomerase from Agrobacterium tumefaciens involved in pectin degradation.Acta Crystallogr F Struct Biol Commun2016
25608448A unique cis-3-hydroxy-l-proline dehydratase in the enolase superfamily.J Am Chem Soc2015
26560079A General Strategy for the Discovery of Metabolic Pathways: d-Threitol, l-Threitol, and Erythritol Utilization in Mycobacterium smegmatis.J Am Chem Soc2015
26472925ATP-binding Cassette (ABC) Transport System Solute-binding Protein-guided Identification of Novel d-Altritol and Galactitol Catabolic Pathways in Agrobacterium tumefaciens C58.J Biol Chem2015
26135041Rate and Equilibrium Constants for an Enzyme Conformational Change during Catalysis by Orotidine 5'-Monophosphate Decarboxylase.Biochemistry2015
25900361Enzyme Function Initiative-Enzyme Similarity Tool (EFI-EST): A web tool for generating protein sequence similarity networks.Biochim Biophys Acta2015
25540822Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes.Biochemistry2015
24450804Galactaro δ-lactone isomerase: lactone isomerization by a member of the amidohydrolase superfamily.Biochemistry2014
25705145Integration of untargeted metabolomics with transcriptomics reveals active metabolic pathways.Metabolomics2014
25275007Investigating the role of a backbone to substrate hydrogen bond in OMP decarboxylase using a site-specific amide to ester substitution.Proc Natl Acad Sci U S A2014
24980702Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks.Elife2014
25145794Investigating the physiological roles of low-efficiency D-mannonate and D-gluconate dehydratases in the enolase superfamily: pathways for the catabolism of L-gulonate and L-idonate.Biochemistry2014
24831290Discovery of a novel L-lyxonate degradation pathway in Pseudomonas aeruginosa PAO1.Biochemistry2014
24870309Roles of small laccases from Streptomyces in lignin degradation.Biochemistry2014
24926996Evolution of enzymatic activities in the enolase superfamily: galactarate dehydratase III from Agrobacterium tumefaciens C58.Biochemistry2014
24947666Identification of the in vivo function of the high-efficiency D-mannonate dehydratase in Caulobacter crescentus NA1000 from the enolase superfamily.Biochemistry2014
24958125Enzyme architecture: deconstruction of the enzyme-activating phosphodianion interactions of orotidine 5'-monophosphate decarboxylase.J Am Chem Soc2014
24520058Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant proline betaine.mBio2014
24697546Discovery of function in the enolase superfamily: D-mannonate and d-gluconate dehydratases in the D-mannonate dehydratase subgroup.Biochemistry2014
24697329Enzymatic and structural characterization of rTSγ provides insights into the function of rTSβ.Biochemistry2014
23452154Computational, structural, and kinetic evidence that Vibrio vulnificus FrsA is not a cofactor-independent pyruvate decarboxylase.Biochemistry2013
24053466Role of a guanidinium cation-phosphodianion pair in stabilizing the vinyl carbanion intermediate of orotidine 5'-phosphate decarboxylase-catalyzed reactions.Biochemistry2013
24056934Discovery of new enzymes and metabolic pathways by using structure and genome context.Nature2013
22069326Divergent evolution in enolase superfamily: strategies for assigning functions.J Biol Chem2012
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Collaborators

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Co-authored papers 44
University of California san francisco
Co-authored papers 36
College of Agricultural and Life Sciences, University of Wisconsin-Madison
Co-authored papers 18
Albert Einstein College of Medicine
Co-authored papers 18
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 16
Helen and Robert Appel Alzheimer's Disease Research Institute, Cornell University
Co-authored papers 13
Harvard Medical School
Co-authored papers 11
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Co-authored papers 11
Texas A&M University, College Station
Co-authored papers 9
Institute for Genomic Biology, University of Illinois
Co-authored papers 7
ShanghaiTech University, China iHuman Institute
Co-authored papers 7
University of California san francisco
Co-authored papers 7
University of Illinois at Urbana-Champaign
Co-authored papers 6
Carl R. Woese Institute for Genomic Biology , University of Illinois
Co-authored papers 6
Cue BioPharma Inc.
Co-authored papers 6
University of Florida
Co-authored papers 6
Albert Einstein College of Medicine
Co-authored papers 6
The State University of New Jersey
Co-authored papers 5
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 5
Albert Einstein College of Medicine
Co-authored papers 5
University of Illinois
Co-authored papers 5
Eli Lilly and Co.
Co-authored papers 4
New York University Grossman School of Medicine
Co-authored papers 4
Texas A&M University, College Station
Co-authored papers 4
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Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 3
University of California San Francisco
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University of Florida
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Pangea Systems Inc., USA and Marine Biological Laboratory
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University of Wisconsin-Madison
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