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Author Details

Kunal S Taskar
Drug Metabolism and Pharmacokinetics
2009
23
12
PMIDPaper TitleJournal TitlePublished Year
36855819Physiologically based pharmacokinetic modeling for development and applications of a virtual celiac disease population using felodipine as a model drug.CPT Pharmacometrics Syst Pharmacol2023
36855819Physiologically based pharmacokinetic modeling for development and applications of a virtual celiac disease population using felodipine as a model drug.CPT Pharmacometrics Syst Pharmacol2023
34862964Current Practices, Gap Analysis, and Proposed Workflows for PBPK Modeling of Cytochrome P450 Induction: An Industry Perspective.Clin Pharmacol Ther2022
35570332Robust physiologically based pharmacokinetic model of rifampicin for predicting drug-drug interactions via P-glycoprotein induction and inhibition in the intestine, liver, and kidney.CPT Pharmacometrics Syst Pharmacol2022
35561140Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective.Clin Pharmacol Ther2022
35421902Physiologically-based pharmacokinetic model-based translation of OATP1B-mediated drug-drug interactions from coproporphyrin I to probe drugs.Clin Transl Sci2022
34862964Current Practices, Gap Analysis, and Proposed Workflows for PBPK Modeling of Cytochrome P450 Induction: An Industry Perspective.Clin Pharmacol Ther2022
35292967Effect of Cyclosporin A and Impact of Dose Staggering on OATP1B1/1B3 Endogenous Substrates and Drug Probes for Assessing Clinical Drug Interactions.Clin Pharmacol Ther2022
35570332Robust physiologically based pharmacokinetic model of rifampicin for predicting drug-drug interactions via P-glycoprotein induction and inhibition in the intestine, liver, and kidney.CPT Pharmacometrics Syst Pharmacol2022
35421902Physiologically-based pharmacokinetic model-based translation of OATP1B-mediated drug-drug interactions from coproporphyrin I to probe drugs.Clin Transl Sci2022
35561140Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective.Clin Pharmacol Ther2022
35292967Effect of Cyclosporin A and Impact of Dose Staggering on OATP1B1/1B3 Endogenous Substrates and Drug Probes for Assessing Clinical Drug Interactions.Clin Pharmacol Ther2022
32460379Intestinal P-gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications.Clin Pharmacol Ther2021
32460379Intestinal P-gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications.Clin Pharmacol Ther2021
33991429Industrial Perspective on the Benefits Realized From the FDA's Model-Informed Drug Development Paired Meeting Pilot Program.Clin Pharmacol Ther2021
33759451When special populations intersect with drug-drug interactions: Application of physiologically-based pharmacokinetic modeling in pregnant populations.Biopharm Drug Dispos2021
33397250Physiologically-based Pharmacokinetic (PBPK) Modelling of Transporter Mediated Drug Absorption, Clearance and Drug-drug Interactions.Curr Drug Metab2021
33759451When special populations intersect with drug-drug interactions: Application of physiologically-based pharmacokinetic modeling in pregnant populations.Biopharm Drug Dispos2021
33991429Industrial Perspective on the Benefits Realized From the FDA's Model-Informed Drug Development Paired Meeting Pilot Program.Clin Pharmacol Ther2021
33397250Physiologically-based Pharmacokinetic (PBPK) Modelling of Transporter Mediated Drug Absorption, Clearance and Drug-drug Interactions.Curr Drug Metab2021
31628859Physiologically-Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug-Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations.Clin Pharmacol Ther2020
32009006Drug Interactions for Low-Dose Inhaled Nemiralisib: A Case Study Integrating Modeling, In Vitro, and Clinical Investigations.Drug Metab Dispos2020
31628859Physiologically-Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug-Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations.Clin Pharmacol Ther2020
32009006Drug Interactions for Low-Dose Inhaled Nemiralisib: A Case Study Integrating Modeling, In Vitro, and Clinical Investigations.Drug Metab Dispos2020
31167838Clinical Extrapolation of the Effects of Dolutegravir and Other HIV Integrase Inhibitors on Folate Transport Pathways.Drug Metab Dispos2019
31167838Clinical Extrapolation of the Effects of Dolutegravir and Other HIV Integrase Inhibitors on Folate Transport Pathways.Drug Metab Dispos2019
28560712Endogenous Probes for Drug Transporters: Balancing Vision With Reality.Clin Pharmacol Ther2018
28560712Endogenous Probes for Drug Transporters: Balancing Vision With Reality.Clin Pharmacol Ther2018
30137645Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective.Clin Pharmacol Ther2018
30137645Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective.Clin Pharmacol Ther2018
28469522Unmasking the Role of Uptake Transporters for Digoxin Uptake Across the Barriers of the Central Nervous System in Rat.J Cent Nerv Syst Dis2017
28469522Unmasking the Role of Uptake Transporters for Digoxin Uptake Across the Barriers of the Central Nervous System in Rat.J Cent Nerv Syst Dis2017
27541873Vinorelbine Delivery and Efficacy in the MDA-MB-231BR Preclinical Model of Brain Metastases of Breast Cancer.Pharm Res2016
27385177Importance of Hepatic Transporters in Clinical Disposition of Drugs and Their Metabolites.J Clin Pharmacol2016
27541873Vinorelbine Delivery and Efficacy in the MDA-MB-231BR Preclinical Model of Brain Metastases of Breast Cancer.Pharm Res2016
27385177Importance of Hepatic Transporters in Clinical Disposition of Drugs and Their Metabolites.J Clin Pharmacol2016
24380373Estimation of the unbound brain concentration of P-glycoprotein substrates or nonsubstrates by a serial cerebrospinal fluid sampling technique in rats.Mol Pharm2014
24380373Estimation of the unbound brain concentration of P-glycoprotein substrates or nonsubstrates by a serial cerebrospinal fluid sampling technique in rats.Mol Pharm2014
22011930Lapatinib distribution in HER2 overexpressing experimental brain metastases of breast cancer.Pharm Res2012
22011930Lapatinib distribution in HER2 overexpressing experimental brain metastases of breast cancer.Pharm Res2012
20829328Heterogeneous blood-tumor barrier permeability determines drug efficacy in experimental brain metastases of breast cancer.Clin Cancer Res2010
20829328Heterogeneous blood-tumor barrier permeability determines drug efficacy in experimental brain metastases of breast cancer.Clin Cancer Res2010
19774344Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer.Pharm Res2009
19789319Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks.Clin Cancer Res2009
19774344Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer.Pharm Res2009
19789319Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks.Clin Cancer Res2009
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Collaborators

Center for Cancer Research, National Cancer Institute
Co-authored papers 5
School of Pharmacy, Texas Tech University Health Sciences Center
Co-authored papers 5
School of Pharmacy, Texas Tech University Health Sciences Center
Co-authored papers 5
Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University
Co-authored papers 4
Pfizer Inc.
Co-authored papers 4
Center for Cancer Research
Co-authored papers 4
Co-authored papers 4
Co-authored papers 3
Department of Pharmaceutical Sciences, Harding University
Co-authored papers 2
Center for Cancer Research
Co-authored papers 2
Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center
Co-authored papers 2
Collegeville
Co-authored papers 1
Center for Cancer Training, National Cancer Institute, National Institutes of Health
Co-authored papers 1
Program Resources Inc. NCI-FCDRC
Co-authored papers 1
Baruch S. Blumberg Institute
Co-authored papers 1
Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 1
Science Applications International Corporation/Frederick
Co-authored papers 1
Discovery and Preclinical Sciences
Co-authored papers 1
Washington State University
Co-authored papers 1
Virginia Commonwealth University
Co-authored papers 1
University of Kansas School of Medicine
Co-authored papers 1
Center for Cancer Research
Co-authored papers 1
Co-authored papers 1
Johns Hopkins School of Medicine, National Cancer Institute, Princeton University, University of Colorado Anschutz Medical Campus, University of Pittsburgh, University of Washington
Co-authored papers 1
The University of Texas MD Anderson Cancer Center
Co-authored papers 1
Goldfinch Bio Inc.
Co-authored papers 1
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Center for Cancer Research, National Cancer Institute
Co-authored papers 1
UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill
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Co-authored papers 1