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Author Details

John A Tainer
The University of Texas MD Anderson Cancer Center
1975
459
114
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36344696Profiling human pathogenic repeat expansion regions by synergistic and multi-level impacts on molecular connections.Hum Genet2023
37665033Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity.Nucleic Acids Res2023
37488098RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles.Nat Commun2023
37696958Dynamics of the DYNLL1-MRE11 complex regulate DNA end resection and recruitment of Shieldin to DSBs.Nat Struct Mol Biol2023
37179334Dynamic conformational switching underlies TFIIH function in transcription and DNA repair and impacts genetic diseases.Nat Commun2023
37369199A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy.Mol Cell2023
37002899Identification of unique α4 chain structure and conserved antiangiogenic activity of α3NC1 type IV collagen in zebrafish.Dev Dyn2023
37034578Dynamics of the DYNLL1/MRE11 complex regulates DNA end resection and recruitment of the Shieldin complex to DSBs.bioRxiv2023
36477609A scanning-to-incision switch in TFIIH-XPG induced by DNA damage licenses nucleotide excision repair.Nucleic Acids Res2023
36641214Combining small angle X-ray scattering (SAXS) with protein structure predictions to characterize conformations in solution.Methods Enzymol2023
36641213Applying HT-SAXS to chemical ligand screening.Methods Enzymol2023
36661847Epigenetic-Metabolic Interplay in the DNA Damage Response and Therapeutic Resistance of Breast Cancer.Cancer Res2023
34748401Stress Responses as Master Keys to Epigenomic Changes in Transcriptome and Metabolome for Cancer Etiology and Therapeutics.Mol Cell Biol2022
35420681Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1.Cancer Discov2022
35969784Two interaction surfaces between XPA and RPA organize the preincision complex in nucleotide excision repair.Proc Natl Acad Sci U S A2022
35291312Cleavage-defective Topoisomerase I mutants sharply increase G-quadruplex-associated genomic instability.Microb Cell2022
35290639Monitoring Nuclease Activity by X-Ray Scattering Interferometry Using Gold Nanoparticle-Conjugated DNA.Methods Mol Biol2022
35290631Universally Accessible Structural Data on Macromolecular Conformation, Assembly, and Dynamics by Small Angle X-Ray Scattering for DNA Repair Insights.Methods Mol Biol2022
35290628Robust Computational Approaches to Defining Insights on the Interface of DNA Repair with Replication and Transcription in Cancer.Methods Mol Biol2022
34918412Distinct sequence features underlie microdeletions and gross deletions in the human genome.Hum Mutat2022
32966823Visualizing functional dynamicity in the DNA-dependent protein kinase holoenzyme DNA-PK complex by integrating SAXS with cryo-EM.Prog Biophys Mol Biol2021
33875777A collagen glucosyltransferase drives lung adenocarcinoma progression in mice.Commun Biol2021
33675849An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation.Prog Biophys Mol Biol2021
33636189Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors.Prog Biophys Mol Biol2021
33798567The renaissance in biophysics and molecular biology enabled by the interface of DNA repair and replication with cancer.Prog Biophys Mol Biol2021
34970273Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy.Front Immunol2021
34966786Decoding Cancer Variants of Unknown Significance for Helicase-Nuclease-RPA Complexes Orchestrating DNA Repair During Transcription and Replication.Front Mol Biosci2021
34815340Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites.Proc Natl Acad Sci U S A2021
34776222An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2.Methods Enzymol2021
34686315Aberrant RNA methylation triggers recruitment of an alkylation repair complex.Mol Cell2021
34561912Target highlights in CASP14: Analysis of models by structure providers.Proteins2021
33941620Autism-Associated Vigilin Depletion Impairs DNA Damage Repair.Mol Cell Biol2021
34348893GRB2 enforces homology-directed repair initiation by MRE11.Sci Adv2021
34181949Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus.J Biol Chem2021
34179826A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors.Nat Cancer2021
34197737EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart.Mol Cell2021
34056803X-ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double-strand break repair impacting cell and cancer biology.Protein Sci2021
33115610Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response.Prog Biophys Mol Biol2021
33197333Heparin-mediated dimerization of follistatin.Exp Biol Med (Maywood)2021
33337499Mechanism of efficient double-strand break repair by a long non-coding RNA.Nucleic Acids Res2021
33330937An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex.Nucleic Acids Res2021
33300026Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin.Nucleic Acids Res2021
33035590Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease.Prog Biophys Mol Biol2021
32522879Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations.Proc Natl Acad Sci U S A2020
31844299The structure of the periplasmic FlaG-FlaF complex and its essential role for archaellar swimming motility.Nat Microbiol2020
32039503Replication-Based Rearrangements Are a Common Mechanism for SNCA Duplication in Parkinson's Disease.Mov Disord2020
33033376Author Correction: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.Nat Cell Biol2020
33045735Mechanism of efficient double-strand break repair by a long non-coding RNA.Nucleic Acids Res2020
33007515Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair.DNA Repair (Amst)2020
32776008XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells.NAR Cancer2020
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Collaborators

Michal Hammel
Lawrence Berkeley National Laboratory
Co-authored papers 34
Greg L Hura
Lawrence Berkeley National Laboratory, University of California Santa Cruz
Co-authored papers 32
Susan P Lees-Miller
University of Calgary, 0 Hospital Drive NW
Co-authored papers 17
Ivaylo Ivanov
Georgia State University, GA 30302 USA Center for Diagnostics and Therapeutics
Co-authored papers 13
Zamal Ahmed
The University of Texas MD Anderson Cancer Center
Co-authored papers 10
Paul Russell
The Scripps Research Institute
Co-authored papers 9
Oliver Limbo
Co-authored papers 7
Michael W W Adams
University of Georgia
Co-authored papers 6
Arthur J Olson
Co-authored papers 6
Shujuan Fang
Charbonneau Cancer Institute, University of Calgary
Co-authored papers 6
Walter J Chazin
and Center for Structural Biology, Vanderbilt University
Co-authored papers 5
Tom L Blundell
Heartand Lung Research Institute, University of Cambridge
Co-authored papers 5
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 5
Mitchell D Miller
Rice University
Co-authored papers 4
David N Cooper
Institute of Medical Genetics, Cardiff University
Co-authored papers 4
Farris L Poole
University of Georgia
Co-authored papers 4
Dina Schneidman-Duhovny
The Hebrew University of Jerusalem
Co-authored papers 4
Alan D D'Andrea
Dana-Farber Cancer Institute
Co-authored papers 4
Olivier Lichtarge
Baylor College of Medicine
Co-authored papers 4
Torsten Schwede
University of Basel
Co-authored papers 3
Andriy Kryshtafovych
University of California davis
Co-authored papers 3
Mien-Chie Hung
Co-authored papers 3
George N Phillips
Rice University
Co-authored papers 3
James Andrew McCammon
Co-authored papers 3
David C Schriemer
University of Calgary, 0 Hospital Drive NW
Co-authored papers 3
Wayne A Hendrickson
Columbia University
Co-authored papers 3
Brian J Haas
Broad Institute of MIT and Harvard
Co-authored papers 3
James M Holton
Lawrence Berkeley National Laboratory
Co-authored papers 3
Tanya T Paull
University of Texas at Austin
Co-authored papers 3
Krzysztof Fidelis
University of California davis
Co-authored papers 3
Release 1.2